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Dietary supplements for patients after lung injury do not appear to improve outcomes; may be harmful
Date:10/5/2011

istration of these supplements would increase the ratio of n-3 to n-6 fatty acids, reduce inflammatory mediators, and improve certain clinical outcomes. The OMEGA study was a randomized, placebo-controlled, multicenter trial conducted from January 2008 through February 2009. Participants were 272 adults within 48 hours of developing ALI requiring mechanical ventilation whose physicians intended to start enteral nutrition at 44 hospitals in the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. The intervention consisted of twice-daily enteral supplementation of n-3 fatty acids (docosahexaenoic acid [DHA] and EPA), GLA, and antioxidants compared with an isocaloric control. The primary measured outcome was the number of ventilator-free days to study day 28.

The study was stopped early for futility at the first interim analysis after 143 patients had been randomized to receive the n-3 supplement and 129 to receive the isocaloric control. All patients had complete follow-up to the earlier of hospital discharge or day 60.

The n-3 study supplement increased plasma EPA levels 8-fold on days 3, 6, and 12, whereas levels in control patients remained unchanged. The researchers found that the n-3 supplement group had fewer ventilator-free days to study day 28 compared with controls (14.0 vs. 17.2) and fewer ICU-free days (14.0 vs. 16.7). "In the n-3 group, 38 of the 143 patients (26.6 percent) died prior to day 60 or hospital discharge compared with 21 of the 129 (16.3 percent) in the control group. When adjusted for baseline variables previously shown to be associated with mortality in ALI, the n-3 group had 25.1 percent 60-day mortality vs. 17.6 percent in the control group [not statistically significant]."

In addition, the n-3 supplement did not protect from hospital-acquired infections or improve nonpulmonary organ function. Patients receiving the n-3 supplement had more frequent instances of gastrointestinal intolerance. '/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
JAMA and Archives Journals
Source:Eurekalert

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