Navigation Links
Dietary medium chain triglycerides prevent nonalcoholic fatty liver disease

Scientists at the Arkansas Children's Nutrition Center, a U.S. Department of Agriculture Agricultural Research Service Human Nutrition Research Center at the University of Arkansas for Medical Sciences, led by Dr. Martin Ronis have determined that dietary substitution of saturated fats enriched in medium chain triglycerides (MCT) for polyunsaturated fat prevents the development of nonalcoholic fatty liver disease (NAFLD). NAFLD occurs in patients with obesity and type II diabetes and is being seen at younger ages in association with the obesity epidemic. NAFLD is characterized by excessive accumulation of fat in the liver. In a proportion of NAFLD cases, liver pathology progresses to hepatitis, fibrosis and liver cancer. The findings which appear in the February 2013 issue of Experimental Biology and Medicine used a laboratory animal model of NAFLD to demonstrate that isocaloric substitution of a mixture of MCT rich saturated fats for of dietary polyunsaturated fats prevented liver fat accumulation. In addition progression of injury was blocked as a result of reduced susceptibility of lipids to radical attack and increased basal metabolic rate produced by activation of PPAR signaling.

"There is a real shortage of potential therapies for NAFLD short of weight loss and increased exercise" states Dr. Ronis. "In this study, we show that even if total dietary fat content remains high and excess calories continue to be consumed, the metabolic effects of MCT to change liver lipid profiles and increase respiration can prevent the development of liver pathology". Although complete substitution of MCT oil for vegetable oils in cooking is not feasible as a result of its low smoking point, the studies demonstrated that the protective effects of MCT were dose-dependent.

Dr. Ronis states that "Future studies will be designed to determine if MCT rich diets can reverse NAFLD and nonalcoholic steatohepatitis in disease models, and if successful, clinical trials may be initiated in patients with metabolic syndrome." Dr. Ronis states that "the technology to produce synthetic cooking oils incorporating MCT is already with us. The Japanese are currently testing an oil containing monounsaturated 18:1 fatty acids and MCT for beneficial health effects. There is no reason why similar synthetic products incorporating saturated fatty acids such as 16:0 or 18:0 and MCT cannot be developed for the US market".

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "with obesity and type II diabetes on the rise development of nonalcoholic fatty liver disease (NAFLD) that can lead to hepatitis, fibrosis and liver cancer is an increasing problem. Dr. Martin Ronis and colleagues using an animal model of NAFLD have shown that substitution of saturated fat in the form of medium chain triglycerides (MCT) for polyunsaturated fats can prevent the progression of NAFLD-associated liver injury. As pointed out by Ronis and colleagues this provides a potential future therapy for NAFLD where we simply alter our cooking oils to contain therapeutic levels of MCTs."


Contact: Martin J. Ronis
Society for Experimental Biology and Medicine

Related medicine news :

1. More Dietary Fiber Might Help Thwart Stroke: Study
2. A Survey Shows The Link Between Dietary Supplements and A Healthy Middle Age Individual
3. Naturel Collagen Canada Now Carrying Colvita – A Dietary Supplement and Nutricosmetic
4. Putting the Dietary Guidelines for Americans into Action: Behavior-Directed messages to Motivate Parents Published in the Journal of the Academy of Nutrition and Dietetics
5. 68% Fake? Japanese Dietary Products Sold on eBay
6. Everyday Vitamin Adds Nature Made’s Odor Control Garlic Dietary Supplement to Product Shelves and Online Inventory
7. Dietary glucose affects the levels of a powerful oncogene in mice
8. Higher dietary glycemic load linked to worse colon cancer survival
9. Increased dietary fructose linked to elevated uric acid levels and lower liver energy stores
10. Nothing Natural About Dietary Supplement DMAA: Study
11. A high intake of certain dietary fats associated with lower live birth rates in IVF
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... the way that they are handling security in light of the recent terrorist attacks ... in an attempt to stop an attack from reaching U.S. soil. Especially around special ...
(Date:11/27/2015)... ... November 27, 2015 , ... A team of Swiss ... to treat it. Surviving Mesothelioma has just posted the findings on the website. ... Zurich analyzed the cases of 136 mesothelioma patients who were treated with chemotherapy followed ...
(Date:11/27/2015)... ... November 27, 2015 , ... "When ... said an inventor from Hillside, N.J. "Many people catch diseases simply from sitting ... individuals will always be protected from germs." , He developed the patent-pending QUDRATECS ...
(Date:11/27/2015)... ... ... The print component of “Supporting Our Caregivers” is distributed ... Minneapolis, South Florida, with a circulation of approximately 250,000 copies and an estimated ... media strategy and across a network of top news sites and partner media ...
(Date:11/27/2015)... ... ... MPWH, the No.1 Herpes-only dating community in the world, revealed that over 50% of its ... 3.7 billion people under the age of 50 – or 67% of the population - ... estimates of HSV-1 infection . , "The data shocks us highly!" said Michelle Li, ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... THOUSAND OAKS, Calif. , Nov. 25, 2015 /PRNewswire/ ... of a Biologics License Application (BLA) with ... Administration (FDA) for ABP 501, a biosimilar candidate to ... the first adalimumab biosimilar application submitted to the FDA ... biosimilar pathway. Sean E. Harper , M.D., ...
(Date:11/25/2015)... On Tuesday, November 24, 2015, the ... Wright Medical Technology, Inc. for product liability and ... implant device, awarded $11 million in favor of ... and three days of deliberations, the jury found ... designed and unreasonably dangerous, and that Wright Medical ...
(Date:11/25/2015)... -- Allergan plc (NYSE: AGN ) today announced that ... York State Attorney General,s Office to end the ... statutes with the Attorney General over the decision of Forest ... selling the now generic version of memantine immediate release tablets.  ... released its counterclaims against New York , ...
Breaking Medicine Technology: