Navigation Links
Dietary medium chain triglycerides prevent nonalcoholic fatty liver disease
Date:4/24/2013

Scientists at the Arkansas Children's Nutrition Center, a U.S. Department of Agriculture Agricultural Research Service Human Nutrition Research Center at the University of Arkansas for Medical Sciences, led by Dr. Martin Ronis have determined that dietary substitution of saturated fats enriched in medium chain triglycerides (MCT) for polyunsaturated fat prevents the development of nonalcoholic fatty liver disease (NAFLD). NAFLD occurs in patients with obesity and type II diabetes and is being seen at younger ages in association with the obesity epidemic. NAFLD is characterized by excessive accumulation of fat in the liver. In a proportion of NAFLD cases, liver pathology progresses to hepatitis, fibrosis and liver cancer. The findings which appear in the February 2013 issue of Experimental Biology and Medicine used a laboratory animal model of NAFLD to demonstrate that isocaloric substitution of a mixture of MCT rich saturated fats for of dietary polyunsaturated fats prevented liver fat accumulation. In addition progression of injury was blocked as a result of reduced susceptibility of lipids to radical attack and increased basal metabolic rate produced by activation of PPAR signaling.

"There is a real shortage of potential therapies for NAFLD short of weight loss and increased exercise" states Dr. Ronis. "In this study, we show that even if total dietary fat content remains high and excess calories continue to be consumed, the metabolic effects of MCT to change liver lipid profiles and increase respiration can prevent the development of liver pathology". Although complete substitution of MCT oil for vegetable oils in cooking is not feasible as a result of its low smoking point, the studies demonstrated that the protective effects of MCT were dose-dependent.

Dr. Ronis states that "Future studies will be designed to determine if MCT rich diets can reverse NAFLD and nonalcoholic steatohepatitis in disease models, and if successful, clinical trials may be initiated in patients with metabolic syndrome." Dr. Ronis states that "the technology to produce synthetic cooking oils incorporating MCT is already with us. The Japanese are currently testing an oil containing monounsaturated 18:1 fatty acids and MCT for beneficial health effects. There is no reason why similar synthetic products incorporating saturated fatty acids such as 16:0 or 18:0 and MCT cannot be developed for the US market".

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "with obesity and type II diabetes on the rise development of nonalcoholic fatty liver disease (NAFLD) that can lead to hepatitis, fibrosis and liver cancer is an increasing problem. Dr. Martin Ronis and colleagues using an animal model of NAFLD have shown that substitution of saturated fat in the form of medium chain triglycerides (MCT) for polyunsaturated fats can prevent the progression of NAFLD-associated liver injury. As pointed out by Ronis and colleagues this provides a potential future therapy for NAFLD where we simply alter our cooking oils to contain therapeutic levels of MCTs."


'/>"/>

Contact: Martin J. Ronis
ronismartinj@uams.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. More Dietary Fiber Might Help Thwart Stroke: Study
2. A Survey Shows The Link Between Dietary Supplements and A Healthy Middle Age Individual
3. Naturel Collagen Canada Now Carrying Colvita – A Dietary Supplement and Nutricosmetic
4. Putting the Dietary Guidelines for Americans into Action: Behavior-Directed messages to Motivate Parents Published in the Journal of the Academy of Nutrition and Dietetics
5. 68% Fake? Japanese Dietary Products Sold on eBay
6. Everyday Vitamin Adds Nature Made’s Odor Control Garlic Dietary Supplement to Product Shelves and Online Inventory
7. Dietary glucose affects the levels of a powerful oncogene in mice
8. Higher dietary glycemic load linked to worse colon cancer survival
9. Increased dietary fructose linked to elevated uric acid levels and lower liver energy stores
10. Nothing Natural About Dietary Supplement DMAA: Study
11. A high intake of certain dietary fats associated with lower live birth rates in IVF
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... June 27, 2017 , ... DrugDev understands that for ... can trust the sponsor to pay them correctly and on time. As the search ... payment strategies that encourage sites to work on their studies. , At a complimentary ...
(Date:6/27/2017)... ... ... The Congressional Budget Office (CBO) projects that the Better Care Reconciliation Act ... Affordable Care Act (ACA), would result in 22 million Americans losing their health insurance ... than 20 million Americans have gained health insurance under the ACA, and from 2013 ...
(Date:6/27/2017)... ... , ... A January 18th article on medGadget reports that the ... the year 2024 according to a new report. The article also notes that the ... Los Angeles area clinic Beverly Hills Periodontics & Dental Implant Center says that it ...
(Date:6/27/2017)... ... June 27, 2017 , ... PR News ... upcoming case studies guidebook. This guidebook offers an excellent branding and exposure opportunity ... articles, case studies and how-to’s that fall into the following categories:, ...
(Date:6/27/2017)... ... June 27, 2017 , ... Dr. Richard Amato, a respected ... practice, Advanced Periodontics and Dental Implant Center of Connecticut. As part of the renovation, ... areas. The renovations are intended to improve patient comfort while making it possible for ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... Hill-Rom Holdings, Inc. (NYSE: HRC), will present at the Goldman ... June 13, 2017, in Rancho Palos Verdes, California ... executive officer, is scheduled to present at 3:20 p.m. Pacific ... at http://ir.hill-rom.com/events.cfm . A recorded replay will be available ... 13, 2017. About ...
(Date:5/26/2017)... BARBARA, Calif. , May 25, 2017  In ... United States , Direct Relief is working with ... overdose-reversing Naloxone available at no cost to community health ... other nonprofit providers nationwide. "Pfizer has ... access to medicines and ensuring patient safety through educational ...
(Date:5/22/2017)... Fla. , May 22, 2017  As ... as a whole continue to make the revolutionary ... becomes increasingly important for ensuring positive patient outcomes ... industry stakeholders are shifting focus away from clinical ... and effects of long-term specialty drug therapy utilization ...
Breaking Medicine Technology: