Navigation Links
Dietary inorganic nitrate may reduce heart dysfunction caused by powerful anti-cancer drug
Date:5/19/2011

RICHMOND, Va. (May 19, 2011) Virginia Commonwealth University researchers have found that nutrient supplementation, like the kind that is found in leafy greens, spinach and lettuce, may reduce the damage to the heart caused by a powerful anti-cancer drug.

Since the 1960s, the anti-cancer drug doxorubicin has remained a top choice for chemotherapy because of its superior efficacy to fight cancer. However, the drug is known to lead to permanent heart damage. Currently, there is no Food and Drug Administration-approved therapy for prevention or treatment of heart damage caused by doxorubicin.

In a study, published online ahead of print on May 16 in the Journal of the American College of Cardiology, using a mouse model the team demonstrated that mice treated with dietary inorganic nitrate had a reduced rate of heart dysfunction caused by doxorubicin. On a molecular level, the dietary nitrate stabilized the mitochondria and protected against free-radical damage to the heart.

"These results may have significant impact in reducing the risk and degree of heart damage in patients who depend on doxorubicin for treatment of cancers. This is because inorganic nitrate is a water-soluble and very inexpensive chemical that could be ideal for long-term oral administration during the course of cancer treatment with doxorubicin," said Rakesh C. Kukreja, Ph.D., principal investigator for the project at VCU, and the Eric Lipman professor in cardiology in the VCU School of Medicine and the scientific director of the VCU Pauley Heart Center.

According to Kukreja, the nitrate dose used in this study is 400 percent of the World Health Organization Acceptable Daily Intake (WHO-ADI). He said that nitrate can easily be obtained from foods including leafy green vegetables, spinach and lettuces, which have high levels of nitrate, or beverages such as beet juice that are commercially available and safely used in humans.

Mitochondria are
'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dietary research offers new explanations and treatments approaches for gastrointestinal disorders
2. Aspirins Clot-Prevention Ability Blunted by Dietary Fat: Study
3. Use of Dietary Supplements Keeps Climbing: CDC
4. Experts at Experimental Biology examine dietary cholesterol, egg intake and heart disease risk
5. Research suggests V8 100% vegetable juice can help people meet key dietary guidelines
6. New U.S. Dietary Guidelines Focus on Salt Reduction
7. High dietary fat, cholesterol linked to increased risk of breast cancer
8. New forms of dietary fiber to boost health
9. IOF statement on new IOM dietary reference intakes for calcium and vitamin D
10. Vitamin D and calcium -- updated dietary reference intakes from IOM
11. New NIST dietary supplement reference materials could be berry useful
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... York, New York (PRWEB) , ... July 31, 2015 , ... ... to strut their stuff, Super-Sod debuted their new type of sod called Leisure ... registered trademark application in process. , To commemorate introduction of this new type of ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... new industry players to know in predictive health analytics , Jvion continues ... technologies. The firm creates predictive software that targets patient and population level illness ...
(Date:7/31/2015)... ... July 31, 2015 , ... Jacksonville-based drug ... new True North Conference Center. The medical community, social workers, law enforcement, and ... be more aligned in the effort to better understand and combat sex trafficking. ...
(Date:7/31/2015)... ... ... According to the article published July 27 on My News LA, a fire ... by the city’s fire department before it caused major damage throughout the building. The article ... and it was a fire alarm system that tipped off fire fighters so they could ...
(Date:7/31/2015)... Dallas, Texas (PRWEB) , ... July 31, 2015 , ... ... Pet Sitter believes community involvement and support of animal welfare organizations is essential to ... for the third consecutive year in the National Association of Professional Pet Sitters (NAPPS) ...
Breaking Medicine News(10 mins):Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4
... revealed that women diagnosed with breast cancer should either ... then they should continue exercising, for it will help ... researchers analysed 500 women, who had survived breast cancer, ... the intensity and amount of physical activity before and ...
... A recent study has found that vegetarian diet reduces risk ... that fatty soup as appetizer reduces food intake by about ... factors like choosing your diet regimen or ordering an appetizer ... ,Researchers from Tata Memorial Hospital (TMH) in Mumbai, India, ...
... condition that most people prefer not to talk about, yet ... embarrassing problem. It's called overactive bladder (OAB) and it's ... causing urine leakage. ,Now, to reduce the symptoms ... nerve stimulation in the ankle to better help control the ...
... researchers at Imperial College London refutes the long-standing "runaway" theory ... fight infection by attacking T helper cells, a class of ... ,Scientists have for long been puzzled as to why this ... decade or more. ,According to the "runaway" hypothesis, ...
... made to recover two missing radiation detectors in the ... of Asia's biggest rivers, a Japanese filmmaker has warned. ... Times who now runs an independent documentary-making agency, is ... to mobilise search and recovery operations on the slopes ...
... study has found that apart from using mobile phones while ... vehicle could increase the risk of a crash. ... intended to determine the danger of a crash related with ... while driving. ,And the researchers found that passengers ...
Cached Medicine News:Health News:Exercise may Help Breast Cancer Patients to Lead a Healthy Life 2Health News:Vegetarian Diet Could Reduce Risk of Colon Cancer 2Health News:Vegetarian Diet Could Reduce Risk of Colon Cancer 3Health News:Vegetarian Diet Could Reduce Risk of Colon Cancer 4Health News:Stimulating the Ankle Can Help Patients With Overactive Bladder 2Health News:Study Refutes Theory on HIV's Effect on White Blood Cells 2Health News:Are Main Rivers in Himalayas Under Threat? 2Health News:Are Main Rivers in Himalayas Under Threat? 3Health News:Not Only Mobile Phones, Even Passengers can Increase the Risk of Road Accidents 2
(Date:7/30/2015)... , July 30, 2015  ResMed (NYSE: ... signed a definitive agreement to acquire Curative ... ventilation and sleep-disordered breathing medical devices and ... market reputation in China, combined with ResMed,s global leadership in sleep and ... China suffering from ...
(Date:7/30/2015)... a special edition of #MedicareMonday on Medicare,s 50 th anniversary. As Medicare celebrates ... continue highlighting the success of the prescription drug benefit, commonly referred to as Part ... infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... 30, 2015  Amgen (NASDAQ: AMGN ) today announced ... director of Warburg Pincus LLC, to the Amgen Board of ... Fred Hassan and the deep, global experience he brings ... Robert A. Bradway , chairman and chief executive officer of Amgen. ... serve Amgen well." Mr. Hassan has been Partner ...
Breaking Medicine Technology:ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3Amgen Announces Appointment Of Fred Hassan To Board Of Directors 2Amgen Announces Appointment Of Fred Hassan To Board Of Directors 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: