Navigation Links
Dietary inorganic nitrate may reduce heart dysfunction caused by powerful anti-cancer drug
Date:5/19/2011

RICHMOND, Va. (May 19, 2011) Virginia Commonwealth University researchers have found that nutrient supplementation, like the kind that is found in leafy greens, spinach and lettuce, may reduce the damage to the heart caused by a powerful anti-cancer drug.

Since the 1960s, the anti-cancer drug doxorubicin has remained a top choice for chemotherapy because of its superior efficacy to fight cancer. However, the drug is known to lead to permanent heart damage. Currently, there is no Food and Drug Administration-approved therapy for prevention or treatment of heart damage caused by doxorubicin.

In a study, published online ahead of print on May 16 in the Journal of the American College of Cardiology, using a mouse model the team demonstrated that mice treated with dietary inorganic nitrate had a reduced rate of heart dysfunction caused by doxorubicin. On a molecular level, the dietary nitrate stabilized the mitochondria and protected against free-radical damage to the heart.

"These results may have significant impact in reducing the risk and degree of heart damage in patients who depend on doxorubicin for treatment of cancers. This is because inorganic nitrate is a water-soluble and very inexpensive chemical that could be ideal for long-term oral administration during the course of cancer treatment with doxorubicin," said Rakesh C. Kukreja, Ph.D., principal investigator for the project at VCU, and the Eric Lipman professor in cardiology in the VCU School of Medicine and the scientific director of the VCU Pauley Heart Center.

According to Kukreja, the nitrate dose used in this study is 400 percent of the World Health Organization Acceptable Daily Intake (WHO-ADI). He said that nitrate can easily be obtained from foods including leafy green vegetables, spinach and lettuces, which have high levels of nitrate, or beverages such as beet juice that are commercially available and safely used in humans.

Mitochondria are cellular organelles critical for converting oxygen and nutrients into ATP, the key fuel for cellular function. The free radicals generated in the mitochondria of cardiac cells by doxorubicin lead to the breakdown of regular cellular function, resulting in programmed cardiac cell death. Over time, cell death has been linked to decreased heart function or heart failure.


'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Related medicine news :

1. Dietary research offers new explanations and treatments approaches for gastrointestinal disorders
2. Aspirins Clot-Prevention Ability Blunted by Dietary Fat: Study
3. Use of Dietary Supplements Keeps Climbing: CDC
4. Experts at Experimental Biology examine dietary cholesterol, egg intake and heart disease risk
5. Research suggests V8 100% vegetable juice can help people meet key dietary guidelines
6. New U.S. Dietary Guidelines Focus on Salt Reduction
7. High dietary fat, cholesterol linked to increased risk of breast cancer
8. New forms of dietary fiber to boost health
9. IOF statement on new IOM dietary reference intakes for calcium and vitamin D
10. Vitamin D and calcium -- updated dietary reference intakes from IOM
11. New NIST dietary supplement reference materials could be berry useful
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... Pass, OR (PRWEB) , ... January 23, 2017 , ... ... took to the air to educate listeners about the benefits of making new water ... the U.S.,” Kleyne said, “it’s appropriate that we expect water infrastructure to become a ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... earned organic certification under the USDA National Organic Program (NOP) for its Portland ... we have established organic production and handling systems to complement our current rigorous ...
(Date:1/23/2017)... ... ... at the Mill”: a story of love and redemption, hope and uncertainty as a ... , “The Inn at the Mill” is the creation of published author, Lois Kulp, ... now living in Berks County on Crow Hill. The inn, the mill and ...
(Date:1/23/2017)... ... , ... Valentine’s Day is a time when many people celebrate romance and love by giving ... looking for the ideal present, Atlanta-based Perimeter Plastic Surgery is offering a Valentine’s ... spend $200 and get $50 free. , “A lot of people just buy the ...
(Date:1/21/2017)... ... January 21, 2017 , ... Caronlab Australia, an Australian company ... ECRM Trade Show in Hilton Head, SC, where it benefited from outstanding meetings with ... of its beauty and wellness products. At this trade show, the company had the ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... -- Ahead of today,s trading session, Stock-Callers.com draws investors, ... at the close: Kite Pharma Inc. (NASDAQ: KITE ), ... and Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ). According to ... Friday, January 20 th , 2017, down on the day by ... stocks now at: ...
(Date:1/23/2017)... 2017 Longer life expectancy and rising healthcare expenditure ... for medical device technologies. BCC Research reveals in its new ... region, should see strong growth due to rising government healthcare ... Continue Reading ... ...
(Date:1/23/2017)... -- ResMed (NYSE: RMD ), BMC (Peking, ... Winter Haven, Florida ) gaben heute bekannt, dass ... globalen Rechtsstreitigkeiten zwischen den Parteien geeinigt haben. BMC und ... im Tausch gegen Lizenzgebühren an ResMed gestattet, und ResMed ... in Florida anhängige Rechtsverfahren zwischen ...
Breaking Medicine Technology: