Navigation Links
Dietary inorganic nitrate may reduce heart dysfunction caused by powerful anti-cancer drug
Date:5/19/2011

RICHMOND, Va. (May 19, 2011) Virginia Commonwealth University researchers have found that nutrient supplementation, like the kind that is found in leafy greens, spinach and lettuce, may reduce the damage to the heart caused by a powerful anti-cancer drug.

Since the 1960s, the anti-cancer drug doxorubicin has remained a top choice for chemotherapy because of its superior efficacy to fight cancer. However, the drug is known to lead to permanent heart damage. Currently, there is no Food and Drug Administration-approved therapy for prevention or treatment of heart damage caused by doxorubicin.

In a study, published online ahead of print on May 16 in the Journal of the American College of Cardiology, using a mouse model the team demonstrated that mice treated with dietary inorganic nitrate had a reduced rate of heart dysfunction caused by doxorubicin. On a molecular level, the dietary nitrate stabilized the mitochondria and protected against free-radical damage to the heart.

"These results may have significant impact in reducing the risk and degree of heart damage in patients who depend on doxorubicin for treatment of cancers. This is because inorganic nitrate is a water-soluble and very inexpensive chemical that could be ideal for long-term oral administration during the course of cancer treatment with doxorubicin," said Rakesh C. Kukreja, Ph.D., principal investigator for the project at VCU, and the Eric Lipman professor in cardiology in the VCU School of Medicine and the scientific director of the VCU Pauley Heart Center.

According to Kukreja, the nitrate dose used in this study is 400 percent of the World Health Organization Acceptable Daily Intake (WHO-ADI). He said that nitrate can easily be obtained from foods including leafy green vegetables, spinach and lettuces, which have high levels of nitrate, or beverages such as beet juice that are commercially available and safely used in humans.

Mitochondria are cellular organelles critical for converting oxygen and nutrients into ATP, the key fuel for cellular function. The free radicals generated in the mitochondria of cardiac cells by doxorubicin lead to the breakdown of regular cellular function, resulting in programmed cardiac cell death. Over time, cell death has been linked to decreased heart function or heart failure.


'/>"/>

Contact: Sathya Achia Abraham
sbachia@vcu.edu
804-827-0890
Virginia Commonwealth University
Source:Eurekalert

Related medicine news :

1. Dietary research offers new explanations and treatments approaches for gastrointestinal disorders
2. Aspirins Clot-Prevention Ability Blunted by Dietary Fat: Study
3. Use of Dietary Supplements Keeps Climbing: CDC
4. Experts at Experimental Biology examine dietary cholesterol, egg intake and heart disease risk
5. Research suggests V8 100% vegetable juice can help people meet key dietary guidelines
6. New U.S. Dietary Guidelines Focus on Salt Reduction
7. High dietary fat, cholesterol linked to increased risk of breast cancer
8. New forms of dietary fiber to boost health
9. IOF statement on new IOM dietary reference intakes for calcium and vitamin D
10. Vitamin D and calcium -- updated dietary reference intakes from IOM
11. New NIST dietary supplement reference materials could be berry useful
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... LINCOLN, R.I. (PRWEB) , ... May 26, 2016 , ... ... season. That’s why Amica Insurance is sharing tips to make sure your ... an estimate from the National Safety Council, there may be 439 deaths and an ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute has partnered with ... class starting June 6 at their clinic in downtown Tampa. The class is complimentary ... Lung Institute has created a free downloadable 4 Week Smoking Cessation Guide ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... of Mehling Orthopedics and chief medical officer of Blue Horizon International (BHI), Brian ... Regeneration. The conference was held during May 5-6, 2016 in Chicago, IL, USA. ...
(Date:5/26/2016)... ... May 26, 2016 , ... Power Systems, a leading developer ... Instructor Certification Course in Stoughton, Massachusetts. The course was led by Power Systems’ ... 8 hour interactive course to qualify participants as certified PowerWave trainers. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... On May 23rd during the National ... Science® and international water advocate, was honored by Ashram, Inc. as the world’s foremost ... who knelt on the banks of the Nile to fill their red clay pots ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... FDA 510(k) clearance covers ... for urological and surgical applications Mauna ... Cellvizio®, the multidisciplinary confocal laser endomicroscopy (CLE) platform, ... US with the 12 th 510(k) clearance ... This new FDA clearance covers Confocal Miniprobes indicated ...
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
(Date:5/25/2016)... 2016  Granger Diagnostics today announced immediate availability of ... infections. This test ensures discovery of ALL bacteria, ... test requires only a simple swab of the wound ... G. Bostwick , MD, Chief Medical Officer, described ... "We are excited to make available, for the ...
Breaking Medicine Technology: