Navigation Links
Diet may eliminate spasms for infants with epilepsy
Date:9/8/2008

Baltimore, Md. September 08, 2008 Infantile spasms are a severe and potentially devastating epilepsy condition affecting children aged typically 4-8 months. In a new study appearing in Epilepsia, researchers have found that the ketogenic diet, a high fat, low carbohydrate diet more traditionally used for intractable childhood epilepsy, is an effective treatment for this condition before using drugs. The study is the first description of the ketogenic diet as a first-line therapy for infantile spasms.

ACTH and vigabatrin, medications that are the commonly-used first treatments worldwide, can have potentially-serious side effects such as hypertension, gastric ulceration, cortical atrophy, and visual field constriction. ACTH, though it is effective in 60-70 percent of cases, also costs more than $80,000 for a one-month supply and vigabatrin is not currently available in the U.S. Both drugs have about a 30-40 percent recurrence rate of spasms as well. Other therapies are not yet proven.

"We decided to review our experience at Johns Hopkins using the ketogenic diet to treat infantile spasms before medications were tried and compare this to our use of ACTH over the same time period," says Eric Kossoff, M.D, a pediatric neurologist at Johns Hopkins Hospital and lead author of the study. "We knew that the ketogenic diet worked well for difficult-to-control infantile spasms, so we thought it would also be effective earlier."

If the diet stopped the spasms, infants were kept on it for usually 6 months. The diet worked in 8-of-13 infants within approximately one week. Only 1-of-8 had recurring spasms, and that infant was controlled again with the addition of topiramate to the diet. Side effects were fewer than ACTH in this series and the recurrence rate was also lower with the diet. In the 5 patients in which the diet did not work, ACTH was started immediately; it worked quickly in 4 of the 5 infants. ACTH did lead to a normal EEG quicker, but long-term developmental outcomes were identical.

As a result of the findings, the ketogenic diet is now one of the typically-offered first-line therapies for new-onset infantile spasms at Johns Hopkins. Other hospitals are beginning to use the ketogenic diet similarly. The researchers hope this novel use of the ketogenic diet may be the first step in finding another treatment to control new-onset infantile spasms.


'/>"/>

Contact: Sean Wagner
swagner@wiley.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Study shows that surgical weight loss does not eliminate obstructive sleep apnea
2. Ben-Gurion University of the Negev initiates project to eliminate intestinal worms in Ethiopia
3. Precancerous Esophagus Disease Eliminated in 98.4% of Patients Treated With HALO Ablation System
4. Ron Greenspan DDS Creates Plan to Eliminate the Barriers to Orthodontic Treatment
5. Bat Scan to the Rescue: New Clubhouse CT Scanner Helps Eliminate Exploding Bats
6. Ultra-High Pressure Processing Eliminates Salmonella in Fresh Tomatoes
7. NHMA, Office of Minority Health Unveil Findings of Summits to Eliminate Health Disparities at Conference April 17-20
8. Verathon(R) Offers Enhanced BladderScan(R) Instrument as Part of Continued Program to Eliminate Unnecessary Catheterizations, Decrease Urinary Tract Infections and Assist in Hospital Infection Control
9. Radian Guaranty Inc. Eliminates Stated Income and Stated Asset Programs
10. Deadly disease eliminated in children under 5 years of age in Uganda
11. New research from the University of Bristol aims to eliminate Streptococcus infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... Element ... products, today announced a strategic partnership with Lucidworks , the company transforming ... analyze their Fusion platform for building powerful enterprise search applications. , Element Blue ...
(Date:1/24/2017)... ... January 24, 2017 , ... Manzo Pharmaceuticals, LLC., announced ... Registered Trademark by the United States Patent and Trademark Office. The purpose ... confuse consumers into thinking that other products are similar to the patented Lacto-Freedom ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... the semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired by Under ... year in 2017. The entrepreneurs will showcase their businesses on February 6, 2017, ...
(Date:1/24/2017)... LONG GROVE, ILL. (PRWEB) , ... January 24, ... ... natural odor abatement solutions, announced that it has officially formed a distribution partnership ... of equipment for the industrial odor management industry. , Through the agreement, OMI ...
(Date:1/24/2017)... , ... January 24, 2017 , ... Center for ... century leadership, has named Hector M. Chavez, Manager, Employee & Labor Relations at ... - as its Hispanic Leader of the Month. City of Hope is committed to ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... LYNBROOK, N.Y. , Jan. 24, 2017 ... BSTC ), a biopharmaceutical company that originated ... a first in class collagenase-based product collagenase ... ┬«  in the U.S. and Xiapex ┬« ... will present a corporate overview at the ...
(Date:1/24/2017)... JOLLA, Calif. , Jan. 24, 2017 ... new case studies using its Biomedical Intelligence® Cloud - ... knowledge from a multitude of genomic, molecular and clinical ... updates were presented at a session hosted by Data4Cure ... Mountain View, CA. The ...
(Date:1/24/2017)... Jan. 24, 2017 Trifecta Clinical , ... is appointing Rick Ward to Vice President ... Trifecta is also announcing the promotion of Ericka ... Rick joins Trifecta from Greenphire where ... held senior business development positions within the healthcare industry ...
Breaking Medicine Technology: