Navigation Links
Diet high in methionine could increase risk of Alzheimer's
Date:12/16/2009

A diet rich in methionine, an amino acid typically found in red meats, fish, beans, eggs, garlic, lentils, onions, yogurt and seeds, can possibly increase the risk of developing Alzheimer's disease, according to a study by Temple researchers.

The researchers published their findings, titled "Diet-induced hyperhomocysteinemia increases Amyloid-β formation and deposition in a mouse model of Alzheimer's disease," in the journal Current Alzheimer Research.

"When methionine reaches too high a level, our body tries to protect itself by transforming it into a particular amino acid called homocysteine," said lead researcher Domenico Pratic, an associate professor of pharmacology in the School of Medicine. "The data from previous studies show even in humans when the level of homocysteine in the blood is high, there is a higher risk of developing dementia. We hypothesized that high levels of homocysteine in an animal model of Alzheimer's would accelerate the disease."

Using a seven-month old mouse model of the disease, they fed one group an eight-month diet of regular food and another group a diet high in methionine. The mice were then tested at 15 months of age the equivalent of a 70-year-old human.

"We found that the mice with the normal diet had normal homocysteine levels, but the mice with the high methionine diet had significantly increased levels of homocysteine, very similar to human subjects with hyperhomocysteinemia," said Pratic. "The group with the high methionine diet also had up to 40 percent more amyloid plaque in their brains, which is a measurement of how much Alzheimer's disease has developed.

The researchers also examined capacity to learn a new task and found it diminished in the group with the diet high in methionine.

Still, Pratic emphasized, methionine is an essential amino acid for the human body and "stopping one's intake of methionine won't prevent Alzheimer's. But people who have a diet high in red meat, for instance, could be more at risk because they are more likely to develop this high level of circulating homocysteine," he said.


'/>"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-4380
Temple University
Source:Eurekalert  

Related medicine news :

1. Controversial kidney transplant technique could provide lifeline for very ill patients
2. New Blood Thinner Could Replace Warfarin to Fight Venous Clots
3. Ginger Prices Could Skyrocket on H1N1 Fears
4. Feeding Birds in Winter Could Speed Evolution of Species
5. Annual Screening With Breast Ultrasound or MRI Could Benefit Some Women
6. Annual screening with breast ultrasound or MRI could benefit some women
7. Swine Flu Waning, But Could Return
8. Engineers, doctors at UCLA develop novel material that could help fight arterial disease
9. Cutting greenhouse pollutants could directly save millions of lives worldwide
10. Drug ads ineffective for boosting sales, could cost taxpayers: UBC-Harvard study
11. Initiative could result in paradigm shift in the care of sickle cell patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diet high in methionine could increase risk of Alzheimer's
(Date:5/27/2017)... ... , ... A May 8 article on CBCNews reports that nearly ... that are not responsive to antibiotics nevertheless obtain prescriptions for them. The article goes ... the problem both in Canada and the United States. Dr. Michael Farzam of House ...
(Date:5/27/2017)... ... ... From May 21-23, hearing healthcare professionals gained a competitive edge with training ... Syracuse Downtown Hotel in Syracuse, New York. , As EarQ’s technology partner, Oticon ... to help them stay ahead in the industry. At the event, EarQ members learned ...
(Date:5/26/2017)... ... May 26, 2017 , ... The American Parkinson ... more than eighty-nine grant submissions all vying for nearly $1,000,000 in funding that ... field.     , The American Parkinson Disease Association (APDA) is focused on advancing scientific ...
(Date:5/26/2017)... ... May 26, 2017 , ... Amir Qureshi, MD is ... powerfully versatile, patient-centric spinal cord stimulation system. The Nuvectra™ Algovita SCS System has been ... pleased to be the first in Arkansas to introduce the most powerful SCS system ...
(Date:5/26/2017)... , ... May 26, 2017 , ... ... delicatessen foods, is sharing bold recipes for Memorial Day entertaining that are sure ... , “Boar’s Head fresh sliced meats and cheeses featured in these refreshingly ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... May 10, 2017 Global Health Intelligence ... Latin America , published its 2017 ranking of the ... based on extensive data analysis from GHI,s hospitals database ... database for the region. The GHI database covers 86% of ... more than 130 data points for each institution in key ...
(Date:5/9/2017)... -- Demonstrating its commitment to representing research- based biopharmaceutical ... Research and Manufacturers of America (PhRMA) today approved ... have to meet new research and development (R&D) ... PhRMA. "By putting in place new ... message that being a member of PhRMA means ...
(Date:5/6/2017)... May 5, 2017   Provista , a proven leader ... 200,000 customers, today announced Jim Cunniff as the ... executive and business experience to Provista, including most recently serving ... California . He assumed his new role ... a great fit for Provista," says Jody Hatcher , ...
Breaking Medicine Technology: