Navigation Links
Diet high in methionine could increase risk of Alzheimer's

A diet rich in methionine, an amino acid typically found in red meats, fish, beans, eggs, garlic, lentils, onions, yogurt and seeds, can possibly increase the risk of developing Alzheimer's disease, according to a study by Temple researchers.

The researchers published their findings, titled "Diet-induced hyperhomocysteinemia increases Amyloid-β formation and deposition in a mouse model of Alzheimer's disease," in the journal Current Alzheimer Research.

"When methionine reaches too high a level, our body tries to protect itself by transforming it into a particular amino acid called homocysteine," said lead researcher Domenico Pratic, an associate professor of pharmacology in the School of Medicine. "The data from previous studies show even in humans when the level of homocysteine in the blood is high, there is a higher risk of developing dementia. We hypothesized that high levels of homocysteine in an animal model of Alzheimer's would accelerate the disease."

Using a seven-month old mouse model of the disease, they fed one group an eight-month diet of regular food and another group a diet high in methionine. The mice were then tested at 15 months of age the equivalent of a 70-year-old human.

"We found that the mice with the normal diet had normal homocysteine levels, but the mice with the high methionine diet had significantly increased levels of homocysteine, very similar to human subjects with hyperhomocysteinemia," said Pratic. "The group with the high methionine diet also had up to 40 percent more amyloid plaque in their brains, which is a measurement of how much Alzheimer's disease has developed.

The researchers also examined capacity to learn a new task and found it diminished in the group with the diet high in methionine.

Still, Pratic emphasized, methionine is an essential amino acid for the human body and "stopping one's intake of methionine won't prevent Alzheimer's. But people who have a diet high in red meat, for instance, could be more at risk because they are more likely to develop this high level of circulating homocysteine," he said.


Contact: Preston M. Moretz
Temple University

Related medicine news :

1. Controversial kidney transplant technique could provide lifeline for very ill patients
2. New Blood Thinner Could Replace Warfarin to Fight Venous Clots
3. Ginger Prices Could Skyrocket on H1N1 Fears
4. Feeding Birds in Winter Could Speed Evolution of Species
5. Annual Screening With Breast Ultrasound or MRI Could Benefit Some Women
6. Annual screening with breast ultrasound or MRI could benefit some women
7. Swine Flu Waning, But Could Return
8. Engineers, doctors at UCLA develop novel material that could help fight arterial disease
9. Cutting greenhouse pollutants could directly save millions of lives worldwide
10. Drug ads ineffective for boosting sales, could cost taxpayers: UBC-Harvard study
11. Initiative could result in paradigm shift in the care of sickle cell patients
Post Your Comments:
Related Image:
Diet high in methionine could increase risk of Alzheimer's
(Date:11/27/2015)... ... , ... MPWH, the No.1 Herpes-only dating community in the world, revealed that over 50% of ... than 3.7 billion people under the age of 50 – or 67% of the population ... global estimates of HSV-1 infection . , "The data shocks us highly!" said Michelle ...
(Date:11/27/2015)... DE (PRWEB) , ... November 27, 2015 , ... ... member of the well-respected Microsoft Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s ... an independent group of Microsoft Dynamics SL software users, partners, industry experts and ...
(Date:11/27/2015)... MINNEAPOLIS, Minn. (PRWEB) , ... November 27, 2015 ... ... you start failing. Secura Consultants has prided itself for not only fulfilling the ... best income protection solutions at an affordable price and providing top-tier customer service. ...
(Date:11/27/2015)... ... ... CBD College is proud to announce that on November 20th, ... its Diagnostic Medical Sonography program. CBD College is honored to join this very short ... universities in the state of California make the cut. CBD College is officially the ...
(Date:11/27/2015)... ... November 27, 2015 , ... Dr. Thomas Dunlap ... and Dr. Tucker Bierbaum with Emergency Medicine at St., Joseph Health System’s ... STEMI and Sepsis conditions present in similar ways and require time-critical intervention to avoid ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... the Global Cell Surface Testing Market: ... report to their offering.  --> ... addition of the  "2016 Future Horizons ...
(Date:11/26/2015)... , Nov. 26, 2015 Research and ... the "Advanced Wound Care Market by Type (Dressings, ... End User (In-Patient Facility, Out-Patient Facility), and Geography - ... --> --> ... description, definition and forecast of the global advanced wound ...
(Date:11/26/2015)... , November 26, 2015 ... the "Self Administration of High Viscosity Drugs" ... ) has announced the addition of the ... report to their offering. --> Research ... addition of the "Self Administration of High ...
Breaking Medicine Technology: