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Diet and medications may assist prevention of prostate cancer
Date:9/23/2007

prostatic hypertrophy. A large clinical trial is underway to evaluate whether this drug prevents malignant biopsies in men with elevated prostate surface antigen levels but previously negative biopsies.

Other studies are currently investigating the role of reduced fat intake and dietary supplements in preventing prostate cancer. In one study of selenium, the incidence of prostate cancer was reduced by 49 percent over ten years. Other nutritional approachs, such as green tea, show conflicting results for prevention. Meanwhile studies of some approaches, like soy and vitamin D, are ongoing. Evidence for the use of vitamin E in the reducing disease rates is promising, but mild safety concerns at high doses currently tested raise caution.

The next five years will be a dynamic period in evaluating several prevention strategies because a host of phase III studies that have been completed and analyzed (i.e. PCPT) or completed accrual will be published.

But in the future, according to the authors, understanding the molecular pathways that develop, sustain and progress malignant cells in the prostate will be critical in the development of new strategies. Data already suggests novel uses of statins, commonly prescribed cholesterol-lowering agents, and insulin modulating drugs, such as metformin or the glitazones. In addition, with further understanding the pathogenesis and related risk factors to identify high-risk patients, we can then use metabolomics, and identify the appropriate agent for effective chemoprevention.


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Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
Source:Eurekalert

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