Navigation Links
Diet, Exercise May Modify Breast Cancer Risks
Date:11/18/2008

Combined, they produce more potent anti-disease effect in postmenopausal women, study says

TUESDAY, Nov. 18 (HealthDay News) -- Scientists believe they have found out why diet and exercise affect a women's chance of breast cancer after she's past menopause, a new study says.

Researchers at the University of Texas at Austin found that cutting calories and exercise affect pathways to mTOR, a molecule that integrates energy balance with cell growth and can contribute to various human diseases when it is not functioning properly.

The research team, expected to present its findings Nov. 18 at the American Association for Cancer Research's annual conference on cancer prevention research, in National Harbor, Md., said these pathways are different, though. Calorie restriction affects more upstream pathways, which may explain why cutting calories delays tumor growth better than exercise when tested on animals.

"One of the few breast cancer modifiable risk factors is obesity," study lead author Leticia M. Nogueira, a research graduate assistant at the University of Texas, said in a news release issued by the conference organizers. "Our study may provide a good scientific basis for medical recommendations. If you're obese, and at high risk for breast cancer, diet and exercise could help prevent tumor growth."

Past research has suggested that consuming fewer calories or increasing exercise levels creates a "negative energy balance" where less energy is taken in than expended, and this lowers the risk of postmenopausal breast cancer associated with obesity. While scientists have thought hormones may play a part in this, it has never been proven.

For the new study, researchers studied 45 obese mice that had their ovaries surgically removed to model the post-menopausal state. After eight weeks, mice fed a calorie-restricted diet had significantly lower blood levels of leptin, a hormone that plays a role in fat metabolism, than those mice only put on an exercise program or those allowed to eat at will with no forced exercise. The calorie-restricted mice also had increased levels of adiponectin, a hormone produced in fat tissue that regulates some metabolic processes, the researchers said.

Some of the cell signaling pathways these hormones manage converge at mTOR, and the researchers found that the key proteins found downstream of mTOR were less active in both the calorie-restricted and exercised mice compared to the controls.

"These data suggest that although exercise can act on similar pathways as caloric restriction, caloric restriction possesses a more global effect on cell signaling and, therefore, may produce a more potent anti-cancer effect," Nogueira said.

More information

The American Cancer Society has more about breast cancer.



-- Kevin McKeever



SOURCE: American Association for Cancer Research, news release, Nov. 18, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Phone World-famed Martin Schiff, M.D., at 310-454-6172 for Free Weight Loss No Diet, No Stuff Method. Hates Diets, Loves to Have People Help Themselves
2. Doctors and Nurses Wellness Checklist: Healthy Diet, Exercise, Dietary Supplements
3. Center for Science Writings presents: Big Fat Lies: The Truth about Diet, Exercise and Obesity
4. be(R) is Making Health Simple With Complimentary, Expert Online Diet, Nutrition and Exercise Advice
5. M. D. Anderson research links diet, gardening and lung cancer risk
6. Diet, Lifestyle Changes Cut Some Infertility Risk
7. Support System Leads to Better Diet, Nutrition
8. Home-based diet and exercise intervention improves elderly cancer survivors physical function
9. Stay Upbeat, Exercise to Help Prevent Cancer in Old Age
10. Exercise improves quality of life for heart failure patients
11. Exercise is safe, improves outcomes for patients with heart failure
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diet, Exercise May Modify Breast Cancer Risks 
(Date:10/13/2017)... ... October 13, 2017 , ... ... in the greater Dallas, Miami, and Raleigh regions, is organizing an extended charity ... a rare and deadly chromosome abnormality. , After struggling since birth with several ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family Medicine's ... President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. ... 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the role ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
(Date:10/4/2017)... OBP Medical , a leading ... today announced regulatory approval from Brazil,s ... Nacional de Vigilância Sanitária (ANVISA)) to market ... with integrated LED light source and smoke evacuation ... of a tissue pocket or cavity during surgical ...
(Date:10/2/2017)... 2, 2017 The Rebound mobile app is poised ... reverse the tide of prescription drug addiction. The app empowers ... intake and stepping down their dosage in a safe, controlled ... December 2017; the first 100,000 people to sign up will ... http://www.rebound-solution.com/ ...
Breaking Medicine Technology: