Navigation Links
Diesel exhaust associated with higher heart attack, stroke risk in men
Date:11/6/2007

ORLANDO, Nov. 6 Increased roadway pollution produced by diesel fuel in vehicles is leading to a cascade of conditions that could result in heart attack or stroke, researchers suggested in the report of a small study presented at the American Heart Associations Scientific Sessions 2007.

United Kingdom and Swedish researchers found that diesel exhaust increased clot formation and blood platelet activity in healthy volunteers which could lead to heart attack and stroke.

The study results are closely tied with previous observational and epidemiological studies showing that shortly after exposure to traffic air pollution, individuals are more likely to suffer a heart attack, said Andrew Lucking, M.D., lead author of the study and a cardiology fellow at the University of Edinburgh in the United Kingdom. This study shows that when a person is exposed to relatively high levels of diesel exhaust for a short time, the blood is more likely to clot. This could lead to a blocked vessel resulting in heart attack or stroke.

The double-blind, randomized, cross-over study included 20 healthy men, 21 to 44 years old. They were separately exposed to filtered air (serving as a control) and to diluted diesel exhaust at 300 micrograms per meter cubed (mcg/m3), a level comparable to curbside exposure on a busy street.

Researchers performed the exposures in a specially built diesel exposure chamber. At two hours and at six hours after exposure, researchers allowed a small amount of participants blood to flow through a perfusion chamber. They measured clot formation, coagulation, platelet activation and inflammatory markers after each exposure.

To measure clot formation, researchers used low and high shear rates, recreating flow conditions inside the bodys blood vessels. Compared to filtered air, breathing air with diluted diesel exhaust increased clot formation in the low shear chamber by 24.2 percent and the high shear chamber by 19.1 percent. This was seen at both two and six hours after diesel exposure.

The researchers also found an increase in platelet activation, assessed by measuring the number of platelets associated with white blood cells. Platelets play a central role in blood clotting, and when they are activated, they associate with white blood cells such as neutrophils and monocytes, Lucking said. Diluted diesel exhaust inhalation increased platelet-neutrophil aggregates from 6.5 percent to 9.2 percent and platelet-monocyte aggregates from 21 percent to 25 percent at two hours after exposure. At six hours, researchers found a trend toward platelet activation, but it was not statistically significant.

After exposure to diesel exhaust, the participants had increased levels of activated platelets that became attached to white blood cells, he said. When activated, the platelets can stick together and form a clot.

High levels of traffic pollution are known to increase the risk of heart attack in the immediate hours or days after exposure. These findings provide a potential mechanism that could link exposure to traffic-derived air pollution with acute heart attack. Its unclear whether these findings would apply to gasoline-powered engines, Lucking said. Diesel engines generate many times more fine pollutant particles than comparable-sized gasoline engines.

Diesel engines are becoming very popular because of increased fuel economy, Lucking said. While diesel engines burn more efficiently, they also put more fine particulate matter into the air.

Lucking encourages physical activity but suggested that people with existing cardiovascular disease try to exercise away from traffic congestion.

The researchers plan to collaborate again with researchers at the University of Umea, Sweden, to test particle traps retrofitted on diesel engines to determine whether these devices are effective in reducing diesel particles.

Exposure to air pollution clearly is detrimental and we must look at ways to reduce pollution in the environment, Lucking said. The U.S. Environmental Protection Agency (EPA) introduced its 1997 National Ambient Air Quality Standards (NAAQS) to educate the public about daily air quality levels, including information about ozone and particulate matter levels. These daily updates can be found on the EPA Web site at www.epa.gov/airnow and in many newspapers across the country.

The American Heart Association supports these EPA guidelines for activity restriction for people with heart disease or those who have certain cardiovascular risk factors, for people with pulmonary disease or diabetes and for the elderly.


'/>"/>

Contact: Karen Astle
karen.astle@heart.org
214-706-1392
American Heart Association
Source:Eurekalert

Related medicine news :

1. Diesel exhaust may increase risk in patients with heart disease
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients
4. Study, meta-analysis examine factors associated with death from heatstroke
5. Increased distance to physician associated with thicker skin cancer at diagnosis
6. Minorities more likely to have sleep durations associated with increased mortality
7. Income inequality associated with overnourishment and undernourishment in India
8. Maternal depression and controlling behavior associated with increased stress response in infants
9. Nurses describe dedication, frustration associated with their jobs
10. New research shows ACTOS is associated with a 38 percent lower risk of heart attack
11. New research shows ACTOS is associated with a 38 percent lower risk of heart attack
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... February 27, 2017 , ... Sunshine Coast Health Centre (SCHC), ... Canada, at https://www.sunshinecoasthealthcentre.ca/ , is proud to announce the addition of a ... the Centre's commitment to innovation in drug rehab and alcohol treatment strategies beyond ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley Hair Institute, a ... an upgrade to the company's Yelp listing. Bay Area residents struggling from thinning ... as Platelet Rich Plasma (PRP) therapy, hair transplantation techniques such as Follicular Unit ...
(Date:2/26/2017)... ... February 25, 2017 , ... The February 13, 2017, assassination of ... concern over nerve agents and the deadly use of chemical weapons. Many questions exist ... how even small doses can be lethal. , Jay Jagannathan, M.D., of Michigan-based Jagannathan ...
(Date:2/26/2017)... ... 2017 , ... This is an extension of airmid’s scope ... ISO/IEC 17025:2005 INAB accredited for Der p 1 (house dust mite allergen) & ... standard that sets out requirements for the technical competence of testing and calibration ...
(Date:2/26/2017)... ... February 26, 2017 , ... LatitudeC ... North America, today announced it would be offering some it’s exclusive product line ... on crafting quality and unique baby clothing/feeding products, will team up with AMAZON ...
Breaking Medicine News(10 mins):
(Date:2/28/2017)... -- Clarivate Analytics marks the passing of one if its founding fathers, Dr. ... science in the service of scientific and scholarly research. A pioneer in ... that revolutionized the way researchers work with the literature, Garfield passed away ... ... Dr. Eugene Garfield, ...
(Date:2/28/2017)... This report provides all the information you ... and activities since 2010. Download the full ... Deals and Alliance since 2010 report provides an in-depth ... world,s leading life sciences companies. On demand ... of the most up to date deal and company ...
(Date:2/28/2017)... Fourth-quarter 2016 revenues of $1,242 million brings ... of guidance Company reports ... associated with the write-down of goodwill and intangible assets ... Fourth-quarter reported $14.96 diluted (GAAP) ... $14.48 diluted (GAAP) loss per share from continuing operations ...
Breaking Medicine Technology: