Navigation Links
Did evolution give us inflammatory disease?
Date:3/22/2013

Boston, MA In new research published in the April 4, 2013 issue of The American Journal of Human Genetics, researchers from Brigham and Women's Hospital (BWH) demonstrate that some variants in our genes that could put a person at risk for inflammatory diseases such as multiple sclerosis, Crohn's disease or rheumatoid arthritis, have been the target of natural selection over the course of human history. The research team, led by Philip De Jager, MD, PhD, BWH Department of Neurology, looked at genome-wide association studies along with protein-protein interaction networks, as well as other data and found 21 places in the genome that bear a 'signature' for inflammatory disease susceptibility brought on by natural selection.

The findings suggest that in the past these variants rose in frequency in the human population to help protect us against viruses, bacteria and other pathogens. But now in our modern world, the environment and exposure to pathogens has changed, and the genetic variants that were originally meant to protect us, now make an autoimmune reaction more likely. These results are consistent with the hygiene hypothesis in which our cleaner environment is thought to contribute to the increasing prevalence of inflammatory diseases.


'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Page: 1

Related medicine news :

1. New Clues to the Evolution of the Human Brain
2. Evolution May Explain Runners High, Study Says
3. Losing money, emotions and evolution
4. A Revolutionary Dietary Paradigm: New Cookbook Features A SOS-free (Salt, Oil, Sugar ) Diet That Delivers the Optimal Food Plan for Renewing Health
5. Vygone Presents a Revolutionary Electro Waveform Device to Help Treat Molluscum Contagiosum Lesions
6. Oxford University Press launches Evolution, Medicine, and Public Health
7. Evolutionary information improves discovery of mutations associated with diseases
8. New Queens spin-in company to revolutionize cancer detection
9. An open platform revolutionizes biomedical-image processing
10. Genes of Africas Khoe-San Peoples Give Clues to Human Evolution
11. Bird tree tells new tale of evolution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 23, 2015 AngelWeddingDress, the premier women’s ... maternity wedding dresses. View website of AngelWeddingDress.com ... for maternity wedding dresses online for a bridal party. ... high quality for them. Its maternity wedding dresses are ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining ... policy . , Auto insurance quotes help many drivers ... longer necessary to call an agent or visit an agency ... a single website: http://autocarinsurancebest.com/ . , Every business who ...
(Date:1/22/2015)... January 22, 2015 Yesterday, Senator ... (D-Concord) and Kristin Olsen (R-Modesto) were honored by ... in advancing biotechnology, biomedical science, medical device and ... each received the “2014 Life Sciences Champion” award ...
(Date:1/22/2015)... 22, 2015 EBSCO Information Services ... expanding their relationship in an effort to further promote visibility ... While EBSCO has long made AMA journals available via its ... for The JAMA Network. , Long known as ...
(Date:1/22/2015)... 22, 2015 Step into a macabre ... Science Museum of Virginia. Wicked Plants, the Museum’s latest ... unearths 75 poisonous, carnivorous and diabolical plants inside of ... to uncover the biochemical, physical and neurological processes between ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Wicked Plants are taking over the Science Museum of Virginia 2
... a novel clinical trial to assess the clinical benefits and ... brain injury in children at the University of Texas. // ... Committee for the Protection of Human Subjects (CPHS) have already ... derived from bone marrow can drift to an injured area ...
... A novel study conducted to analyze the fluctuations in ... it may vary over different seasons with a tendency ... supported by the fact that there is a corresponding ... Researchers at University of Massachusetts Medical School in Worcester ...
... Americans consume far too much sodium, putting them at ... according to a new study published in the current ... , ,Although people who already have high blood ... their average daily intake is still far higher than ...
... at the Vrije University in Amsterdam in collaboration with the University ... , Usually in case of throat cancer the larynx ... surgically removed. , The patients after this surgery find ... This valve is implanted in-between the windpipe and oesophagus. ...
... to be in the grip of chicken pox. In spite ... district have been affected by the disease //which causes cold, ... chicken pox, villagers of 90 villages falling under Firozabad District ... disease. Interestingly, even medicines don’t seem to have any effect ...
... most popular movie ‘Stuart Little’ may no longer be ... proved from experiments// that it is technically possible to ... techniques. ,It has now been found that ... benefits can be made functional inside another experimental animal ...
Cached Medicine News:Health News:Stem Cell Treatment For Children With Brain Injury To Be Initiated 2Health News:Seasonal Variation In Exercise And Eating Habits Identified 2Health News:Americans Consume Far Too Much Salt and Sodium 2Health News:Chicken pox Spreads Across Firozabad 2Health News:Mice With Human Thought Processes Could Be Developed In The Future 2
(Date:1/23/2015)... CAPE TOWN, South Africa , Jan. 23, 2015 ... and distributor of personal protective equipment for all forms ... include the flagship Leatt-Brace® neck brace, announced today that ... minicross racing federation, now requires all riders to wear ...
(Date:1/23/2015)... , Jan. 23, 2015 Gem Pharmaceuticals announced today ... been enrolled into the Company,s Phase 2 clinical trial. ... of Gem,s lead compound, GPX-150 (an investigational medication), in ... metastatic disease. Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
Breaking Medicine Technology:Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... Aethlon Medical, Inc. (OTC Bulletin Board: AEMD) disclosed ... Hepatitis-C (HCV) infected patients with the Aethlon Hemopurifier® will ... Exposition of the American Society of Nephrology (ASN). Dr. ... Director of Nephrology at the Fortis Hospital in New ...
... , MARIETTA, Ga., Oct. 15 Solvay Pharmaceuticals, Inc. ... Delayed-Release Capsules significantly improves a key measure of fat ... pancreatic insufficiency (EPI) due to cystic fibrosis (CF). EPI ... production and/or secretion of pancreatic enzymes that are necessary ...
Cached Medicine Technology:Aethlon Medical Announces Presentation of Hepatitis-C (HCV) Clinical Data at 42nd Annual American Society of Nephrology (ASN) Conference 2Aethlon Medical Announces Presentation of Hepatitis-C (HCV) Clinical Data at 42nd Annual American Society of Nephrology (ASN) Conference 3CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 2CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 3CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 4CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 5CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 6
Passive heat and moisture exchangers for respiratory applications....
Ballard trach care HMES and filters, tv 500, HME...
... Thermovent® T helps provide protection to the exposed ... and extremely lightweight making it ideal for active ... high rate of heat and moisture recovery, it ... ,All HMEs and filters have ISO standard tapered ...
For use with: , pulmonary function testing , nebulizer compressors , humidifiers , concentrators , proximal pressure lines ...
Medicine Products: