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Diagnostic coronary angiography: Functional flow reserve changes decisions in 25 percent of cases
Date:5/24/2013

a second cardiologist. The FFR results were shown to the first cardiologist, who used them to develop a second treatment plan (plan 2) for that patient. The primary endpoint of the study was the difference between plan 1 and plan 2 for each patient.

"Routine use of FFR at diagnostic coronary angiography resulted in a significant change in management in 26% of patients," Curzen reported. FFR led to a change in the judgement of whether a coronary artery had a 'significant' lesion in 64 patients (32%) compared to angiogram alone. "These results have potentially important implications for clinical practice," he concluded. "Management of patients with stable angina alone is flawed and would be improved by routine use of FFR at the diagnostic stage." He suggested that RIPCORD has provided proof of principle and that a large-scale randomised trial comparing angiographic- with FFR-guided assessment and management of patients with stable angina undergoing diagnostic angiography is now warranted.

Commenting on the implications of the study findings, Kari Niemela, Medical Director and founder of the Heart Center Co., Tampere University Hospital, Tampere, Finland, said, "The RIPCORD trial demonstrated that routine measurement of FFR in patients with stable angina pectoris changes treatment plan in one out of four patients as compared to visual evaluation with coronary angiography alone." He added, "As the number of patients in this highly interesting multicentre trial was relatively small (200 patients), a large-scale randomised controlled trial including a health economic assessment of both diagnostic options for routine use is justified."


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Contact: Isabelle Uzielli
iuzielli@europcr.com
European Society of Cardiology
Source:Eurekalert

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