Navigation Links
Diagnostic brain tumor test could revolutionize care of patients
Date:1/27/2012

DALLAS Jan. 26, 2012 Researchers at UT Southwestern Medical Center have developed what they believe to be the first clinical application of a new imaging technique to diagnose brain tumors. The unique test could preclude the need for surgery in patients whose tumors are located in areas of the brain too dangerous to biopsy.

This new magnetic resonance spectroscopy (MRS) technique provides a definitive diagnosis of cancer based on imaging of a protein associated with a mutated gene found in 80 percent of low- and intermediate-grade gliomas. Presence of the mutation also means a better prognosis.

"To our knowledge, this is the only direct metabolic consequence of a genetic mutation in a cancer cell that can be identified through noninvasive imaging," said Dr. Elizabeth Maher, associate professor of internal medicine and neurology at UT Southwestern and senior author of the study, available online in Nature Medicine. "This is a major breakthrough for brain tumor patients."

UT Southwestern researchers developed the test by modifying the settings of a magnetic resonance imaging (MRI) scanner to track the protein's levels. The data acquisition and analysis procedure was developed by study lead author Dr. Changho Choi, associate professor of the Advanced Imaging Research Center (AIRC) and radiology. Previous research linked high levels of this protein to the mutation, and UT Southwestern researchers already had been working on MRS of gliomas to find tumor biomarkers.

"Our next step is to make this testing procedure widely available as part of routine MRIs for brain tumors. It doesn't require any injections or special equipment," said Dr. Maher, medical director of UT Southwestern's neuro-oncology program.

To substantiate the test as a diagnostic tool, biopsy samples from 30 glioma patients enrolled in the UT Southwestern clinical trial were analyzed; half had the mutation and expected high levels of the protein. MRS imaging of these patients had been done before surgery and predicted, with 100 percent accuracy, which patients had the mutation.

For Thomas Smith of Grand Prairie, the test helped determine the best time to begin chemotherapy. When an MRS scan showed a sharp rise in the 25-year-old's protein levels, this indicated to his health care team that his tumor was moving from dormancy to rapid growth.

"We treated him with chemotherapy and his protein levels came down," Dr. Maher said.

Before participating in the study, Mr. Smith had tumor removal surgery in 2007. Because part of the tumor could not be safely removed, however, he continued to suffer seizures and had other neurological problems. Since chemotherapy, his symptoms have diminished.

"I did six rounds of chemo, every six weeks," Mr. Smith said. "My seizures stopped and all my symptoms improved. I am only on anti-seizure medication now."


'/>"/>

Contact: Debbie Bolles
debbie.bolles@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. Autism redefined: Yale researchers study impact of proposed diagnostic criteria
2. Journal of Clinical Virology assembles papers on HIV diagnostic testing algorithms
3. Discordance among commercially-available diagnostics for latent TB infection
4. New life-saving diagnostic test for HIV patients featured in Better World Report
5. Diagnostic physicians at increased risk for medical malpractice claims due to communication failures
6. Princeton investment conference explores revolutionary laser-based medical diagnostics
7. IRB Barcelona spin-off to develop a diagnostic kit and new treatments for metastasis
8. New diagnostic imaging for lung cancer could prevent unnecessary surgery
9. IADR/AADR publish proceedings from the AADR Fall Focused Symposium on Salivary Diagnostics
10. TEMLA shows higher diagnostic yield than EBUS or EUS in largest reported series to date
11. Noninvasive diagnostics may offer alternative to liver biopsy for assessing liver fibrosis
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diagnostic brain tumor test could revolutionize care of patients
(Date:12/8/2016)... , ... December 08, 2016 , ... Coppin Insurance Agency, ... and families in and around the Cape Coral area, is embarking on a charity ... Bank of Southwest Florida. , The Harry Chapin Food Bank of Southwest Florida works ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... to families and business owners in and around central Kansas, is joining the ... at-risk youth in the region. , Headquartered in Wichita, Youth Horizons works to ...
(Date:12/7/2016)... ... December 07, 2016 , ... "Today, MHA ... most comprehensive mental health systems reform legislation in more than fifty years. We ... the commitment of our elected officials to improving mental health services and supports ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... treat wrinkles and deep lines by smoothing and tightening the skin of the ... out there to address facial aging with very little downtime, Silhouette Instalift is ...
(Date:12/7/2016)... ... December 07, 2016 , ... EnghouseSystems ... purchase price of approximately $17.4 million (net of the cash acquired), subject ... $13.2 million. Headquartered in Barcelona, Spain, Presence is a leading provider of ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016 Noom, Inc., ... it will charge enterprise customers only when their members ... the health and wellness sector, which typically charges for ... - http://photos.prnewswire.com/prnh/20161207/446824LOGO ... the power of technology with the empathy of live ...
(Date:12/8/2016)... BRAINTREE, Mass. , Dec. 8, 2016  Haemonetics Corporation ... to NextGen DMS (Donor Management System), an innovative software suite ... operations. The launch of NextGen DMS 4 ... focus including: reducing the cost per liter of plasma collected, ... and improve plasma center operations. ...
(Date:12/8/2016)... -- Stock-Callers.com revisits the Drug Manufacturers industry, ... of pharmaceutical drug products. Companies in this space can ... these firms typically have dividend yields that are higher ... review this morning are: Novo Nordisk A/S (NYSE: ... SGYP ), Pernix Therapeutics Holdings Inc. (NASDAQ: ...
Breaking Medicine Technology: