Navigation Links
Diabolical duo: Known breast cancer gene needs a partner to initiate and spread tumors
Date:6/26/2014

progression of disease," Haffty said. "Although these results are too early to have an immediate impact on cancer treatment, they are very exciting."

Eileen White, associate director of basic science at Rutgers-CINJ, who is familiar with the work but did not directly participate in it, said, "This research found that the proteins MTDH and SND1 were highly expressed in a battery of different breast cancers, so interfering with these two proteins might have anti-cancer activity in a spectrum of breast cancers."

To learn more about the physical nature of the interaction of MTDH with SND1 and to find a way to block this cancer-promoting interaction, the Kang lab enlisted the help of researchers led by Yongna Xing at the University of Wisconsin-Madison. The team used X-ray crystallography a technique that enables researchers to see structures that are too small to see with microscopes to visualize the two proteins when bound to each other.

The researchers found that MTDH has two finger-like projections that stick into two pockets on the surface of SND1. "They are like two fingers sticking into the holes of a bowling ball," said Kang. The discovery of the binding gave rise to ideas about how to block it and thus block tumor initiation.

The team is currently screening small molecules that could block the binding of MTDH to SND1 and curtail its tumor-promoting functions. "MTDH stabilizes SND1 and that is the lifeboat for the so-called cancer stem cells that initiate primary tumors and metastasis," Kang said. "Without MTDH, SND1 will be degraded and the seeds of cancer will be wiped out."

Additional research from the Kang lab and other researchers around the world has revealed that Metadherin gene overexpression is seen in about 20 cancer types, indicating that an MTDH-blocking strategy may be able to overcome a variety of cancers.


'/>"/>

Contact: Catherine Zandonella
czandone@princeton.edu
609-258-0541
Princeton University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Internationally known expert in ovarian cancer to be honored at the ASCO Annual Meeting
2. Well-known author and historian reports on progress in Huntingtons therapies
3. Yoga reduces stress; now its known why
4. Well-known protein reveals new tricks
5. Patients with aberrations in two genes respond better to drugs blocking a well-known cancer pathway
6. Researchers implicate well-known protein in fibrosis
7. Mega Travel Club Travel Services (also known as mytsonline) Implements New Program to Help Members Avoid the Internet Scams and Ripoffs
8. The Company Known for Providing Hearing Aids in Corpus Christi TX, Hearing Aid Company of Texas, Now Offers Complimentary Hearing Assessments
9. East End Hearing, Company Known for the Best Audiologist in Long Island NY and Surrounding Communities, Now Offers Online Hearing Test
10. Little Known on How to Best Help Kids After Trauma
11. Little-Known Respiratory Infection Sends Many Kids to Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diabolical duo: Known breast cancer gene needs a partner to initiate and spread tumors
(Date:12/25/2014)... is common during the holidays, but there are strategies that ... "Don,t arrive at a party hungry. It may seem logical ... a party, but deprivation leads to hunger, and hunger leads ... in Mount Kisco, N.Y., said in a hospital news release. ... even to have a snack before attending a party when ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... on a "fountain of youth" drug that can delay the ... a new study suggests. Seniors received a significant boost ... a genetic signaling pathway linked to aging and immune function, ... The experimental medication, a version of the drug rapamycin, improved ...
(Date:12/25/2014)... Thousands of transvaginal mesh lawsuits ( ... number of multidistrict litigations currently underway in U.S. District ... reports. According to an Order issued on December 2, ... Status Conference in all of the proceedings on January ... to submit a proposed agenda to the Court by ...
(Date:12/25/2014)... 25, 2014 Plugin creators from Pixel ... A fully customizable business presentation tool made specifically for ... ProFire 5k business tool, users can now display their ... of Pixel Film Studios. “ProFire 5k gives users a ... add professionalism to a presentation” , Pixel Film Studios ...
(Date:12/25/2014)... Rosa, CA (PRWEB) December 25, 2014 ... department visits and 2 million hospital admissions across the ... and Prevention ). The CDC’s National Hospital Ambulatory ... departments through a survey conducted in 2010. They estimated ... department visits that resulted in a primary diagnosis of ...
Breaking Medicine News(10 mins):Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 2Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 3Health News:Every Year Four Million Emergency Department Visits Result from Accidents Involving Bone Trauma 4
... sure they,ve made the right choice , ... ... annual Medicare enrollment has ended, some Medicare Advantage beneficiaries can ... period. That information comes from Allsup , a leading ...
... Jan. 12 Acclarent, Inc., a leading,medical technology ... address conditions affecting the ear, nose and,throat, announced ... financing round.,Acclarent intends to use the proceeds to ... as on-going investment in product,development and clinical studies. ...
... recall of King Nut brand after Minn. officials find bacteria ... been sickened , , SUNDAY, Jan. 11 (HealthDay News) -- ... for two brands of peanut butter after health officials in ... a tub of peanut butter that is distributed to schools ...
... giving guests a reason to be cheerful by announcing a winter sale ... ... (PRWEB) January 11, 2009 -- The Linwood Group has revealed that it ... can access its first rate facilities., , ,From Christmas through to the ...
... Ohio-based manufacturer and long-standing leader in the development of ergonomic ... with a solution to a unique furnishing challenge it faced ... ... Bowling Green, OH (PRWEB) January 10, 2009 ...
... The Asthma and Allergy Foundation of America (AAFA) announces ... been appointed to the Council of the National Institute ... the National Institutes of Health (NIH), for a four-year ... provides a diverse perspective on science, health and the ...
Cached Medicine News:Health News:Medicare Advantage Open Enrollment Offers One-Time Chance to Change Your Mind: Allsup Outlines Rules for Switching Plans 2Health News:Medicare Advantage Open Enrollment Offers One-Time Chance to Change Your Mind: Allsup Outlines Rules for Switching Plans 3Health News:Medicare Advantage Open Enrollment Offers One-Time Chance to Change Your Mind: Allsup Outlines Rules for Switching Plans 4Health News:Medicare Advantage Open Enrollment Offers One-Time Chance to Change Your Mind: Allsup Outlines Rules for Switching Plans 5Health News:Acclarent, Inc. Closes $26 Million Financing 2Health News:Peanut Butter Recalled as Salmonella Search Continues 2Health News:Peanut Butter Recalled as Salmonella Search Continues 3Health News:Peanut Butter Recalled as Salmonella Search Continues 4Health News:Linwood Group Setting Price Benchmark for Alcohol Rehab 2Health News:BioFit 1Y Takes the Plunge to Fill Undersea Seating Role for NOAA 2Health News:Asthma & Allergy Foundation CEO Appointed to NIH Council 2
(Date:12/24/2014)... , Dec. 23, 2014  Advanced Medical Isotope ... engaged primarily in the development of brachytherapy devices ... today announced that it has filed a ... Drug Administration ("FDA") for marketing clearance for its ... of the U.S. Food, Drug and Cosmetic Act ...
(Date:12/24/2014)... Dec. 23, 2014   Assurex Health, a ... to healthcare providers for behavioral health and chronic ... $30 million in equity financing from new and ... , President and Chief Executive Officer. ... development of Assurex Health,s GeneSight ® ...
(Date:12/24/2014)... SANTA BARBARA, Calif. , Dec. 23, 2014 ... the Junior Doctors, Association of Sierra Leone ... Sierra Leone for the treatment of local ... While a new dedicated Ebola care center was ... Ebola virus, the facility is not available for local Sierra ...
Breaking Medicine Technology:Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2
... 29 FUJIFILM Medical Systems USA, Inc. is pleased to ... at the 2009 Radiological Society of North America (RSNA) Annual ... an innovative new technology to provide clinicians with Fujifilm,s trademark ... a smart way for users to transition to DR without ...
... Nov. 28 Siemens Healthcare redefines productivity with a ... technology and with its new Dot(TM) (Day optimizing throughput) engine. ... Aera* 1.5 Tesla (T) and the new MAGNETOM Skyra* 3T ... the Radiological Society of North America (RSNA) from November 29 ...
Cached Medicine Technology:FUJIFILM's DR Cassette Makes World Debut 2Siemens Introduces Its New Power Couple at RSNA 2009 2Siemens Introduces Its New Power Couple at RSNA 2009 3Siemens Introduces Its New Power Couple at RSNA 2009 4Siemens Introduces Its New Power Couple at RSNA 2009 5Siemens Introduces Its New Power Couple at RSNA 2009 6Siemens Introduces Its New Power Couple at RSNA 2009 7
Kit for the Preparation of Technetium Tc 99m Sestamibi for injection...
Straight Tip, Measures from 0mm to 20mm in 1mm Increments, Readable on Both Sides, Thumbscrew Lock Holds Desired Setting; in Titanium....
Very fine, blunt tip....
... The e.cam duet Signature Series ... and PET FDG imaging applications. The system ... capability with the features and flexibility of ... in one unit.,The e.cam duet ...
Medicine Products: