Navigation Links
Diabetes treatment may also provide protection against endometrial cancer

Research led by Warwick Medical School at the University of Warwick has found that Metformin, a drug treatment used to treat diabetes and also in women with Polycystic vary syndrome (PCOS), may potentially provide protection against endometrial cancer.

Endometrial cancer is the most common malignancy of the female genital tract and the fourth most common cancer in women in the UK and the US. Up to a third of PCOS women also have endometrial hyperplasia which, in turn predisposes these women to endometrial cancer. PCOS affects 5%-10% of women of reproductive age, where Metformin ameliorates insulin resistance and hyperinsulinemia in these women, but also long-term use of Metformin improves ovulation and menstrual cycle regularity.

Recent research has found that Metformin has anti-cancer properties e.g. in breast cancer. Given that insulin resistant states, e.g. obesity, diabetes and PCOS are more at risk of developing endometrial cancer, the Warwick researchers studied the effects of metformin treatment on endometrial cancer cells. The researchers used serum from control and PCOS (before and after metformin treatment) subjects and carried out basic scientific experiments on endometrial cancer cells. The experiments revealed a decrease in endometrial cancer cell invasiveness in sera from metformin treated PCOS women.

The researchers found that serum samples from PCOS women who had completed the 6 month course of Metformin the rate of spread of endometrial cancer cells was around 25% lower than in the serum samples from PCOS women who had not started that treatment.

The principal investigators, Dr Harpal Randeva and Dr Bee K Tan, at Warwick Medical School said: "We are very excited about our findings, which reveal the significant impact of Metformin therapy use on human endometrial cancer cells. However, it is prudent that further research to explore if Metformin would actually be beneficial clinically as adjuvant therapy in endometrial cancer; this would need to be addressed through a randomized controlled trial."


Contact: Dr. Harpal S. Randeva
University of Warwick

Related medicine news :

1. Add Cancer to Health Risks of Diabetes: Study
2. Avoiding or controlling diabetes may reduce cancer risk and mortality
3. Bariatric surgery reduces long-term cardiovascular risk in diabetes patients
4. Bariatric surgery highly cost-effective treatment for type 2 diabetes in the obese
5. International Diabetes Federation supports surgery to treat diabetes
6. Nick Jonas Lives Large, Despite Diabetes
7. Actos Cut Risk of Prediabetes Becoming Diabetes in Study
8. Study Ties Asthma to Higher Odds for Diabetes, Heart Disease
9. Metabolite levels may be able to improve diabetes risk prediction
10. Analysis Confirms Diabetes Drug May Harm the Heart
11. Diabetes Surgery 2nd World Congress
Post Your Comments:
Related Image:
Diabetes treatment may also provide protection against endometrial cancer
(Date:11/30/2015)... MN (PRWEB) , ... November 30, 2015 , ... ... at . The directory is specialized and only includes chiropractic clinics ... to find a competent and trustworthy alternative health practitioner when back pain sets ...
(Date:11/30/2015)... ... November 30, 2015 , ... The Museum ... summer, ushering in a new era of publicly accessible automated technology. Now, by ... continue to offer guests an up-close look at the shuttle at MOSI’s main ...
(Date:11/30/2015)... ... November 30, 2015 , ... In an effort to provide ... of Life Christian Church of Flint, MI, hosted a family-oriented evening themed on ... pile of candy dubbed “Candy Mountain”. , A Forever Recovery, a holistic treatment ...
(Date:11/30/2015)... ... November 30, 2015 , ... In an ... States to access life-saving information provided directly from top experts in mesothelioma, ... three individual conferences in three major cities: Houston, San Francisco, and Chicago. ...
(Date:11/30/2015)... ... 2015 , ... During the week of Thanksgiving, the Mesothelioma ... its research, education, support, and advocacy efforts. The campaign is held every year-end ... Applied Research Foundation, which also goes by Meso Foundation, holds the highest ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... -- MEDTEC Japan 2016, Asia,s largest exhibition and conference ... in Tokyo from 20 th  - 22 nd April 2016. ...   --> -->   ... . With the aging population and the government back up, the Medical ... the United States . With the aging population and the ...
(Date:11/30/2015)... , Nov. 30, 2015 Nevro Corp. (NYSE: ... innovative evidence-based solutions for the treatment of chronic pain, today ... the U.S. Patent and Trademark Office (USPTO) has denied instituting ... No. 8,359,102 (the ,102 patent).  --> ... of Boston Scientific Corporation filed two petitions challenging the validity ...
(Date:11/30/2015)... ) has ... Market 2015-2019" report to their offering. ... of the "Orphan Drugs Market 2015-2019" ... and Markets ( ) has announced the ... report to their offering. ...
Breaking Medicine Technology: