Navigation Links
Diabetes treatment may also provide protection against endometrial cancer
Date:4/5/2011

Research led by Warwick Medical School at the University of Warwick has found that Metformin, a drug treatment used to treat diabetes and also in women with Polycystic vary syndrome (PCOS), may potentially provide protection against endometrial cancer.

Endometrial cancer is the most common malignancy of the female genital tract and the fourth most common cancer in women in the UK and the US. Up to a third of PCOS women also have endometrial hyperplasia which, in turn predisposes these women to endometrial cancer. PCOS affects 5%-10% of women of reproductive age, where Metformin ameliorates insulin resistance and hyperinsulinemia in these women, but also long-term use of Metformin improves ovulation and menstrual cycle regularity.

Recent research has found that Metformin has anti-cancer properties e.g. in breast cancer. Given that insulin resistant states, e.g. obesity, diabetes and PCOS are more at risk of developing endometrial cancer, the Warwick researchers studied the effects of metformin treatment on endometrial cancer cells. The researchers used serum from control and PCOS (before and after metformin treatment) subjects and carried out basic scientific experiments on endometrial cancer cells. The experiments revealed a decrease in endometrial cancer cell invasiveness in sera from metformin treated PCOS women.

The researchers found that serum samples from PCOS women who had completed the 6 month course of Metformin the rate of spread of endometrial cancer cells was around 25% lower than in the serum samples from PCOS women who had not started that treatment.

The principal investigators, Dr Harpal Randeva and Dr Bee K Tan, at Warwick Medical School said: "We are very excited about our findings, which reveal the significant impact of Metformin therapy use on human endometrial cancer cells. However, it is prudent that further research to explore if Metformin would actually be beneficial clinically as adjuvant therapy in endometrial cancer; this would need to be addressed through a randomized controlled trial."


'/>"/>

Contact: Dr. Harpal S. Randeva
Harpal.Randeva@warwick.ac.uk
44-247-657-2552
University of Warwick
Source:Eurekalert  

Related medicine news :

1. Add Cancer to Health Risks of Diabetes: Study
2. Avoiding or controlling diabetes may reduce cancer risk and mortality
3. Bariatric surgery reduces long-term cardiovascular risk in diabetes patients
4. Bariatric surgery highly cost-effective treatment for type 2 diabetes in the obese
5. International Diabetes Federation supports surgery to treat diabetes
6. Nick Jonas Lives Large, Despite Diabetes
7. Actos Cut Risk of Prediabetes Becoming Diabetes in Study
8. Study Ties Asthma to Higher Odds for Diabetes, Heart Disease
9. Metabolite levels may be able to improve diabetes risk prediction
10. Analysis Confirms Diabetes Drug May Harm the Heart
11. Diabetes Surgery 2nd World Congress
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diabetes treatment may also provide protection against endometrial cancer
(Date:2/6/2016)... ... February 06, 2016 , ... ... eating disorder treatment helps to reduce the frequency and level of relapse. ... Phase: Re-Establishing Healthy Identity and Purpose,” will explore the critical tasks of the ...
(Date:2/5/2016)... & Salt Lake City, UT (PRWEB) , ... February 05, 2016 ... ... of Activz Whole-Food Nutrition , announced that the much-anticipated feature with author Jahnavi ... New Really Cool Humans Amateur TV Network. , Each week, on his weekly Whole-Food ...
(Date:2/5/2016)... Santa Rosa, CA (PRWEB) , ... February 05, ... ... are pleased to announce the addition of micro-needling services in their Napa Valley ... appearance. The founders of Plastic Surgery Associates, Dr. Canales and Dr. Furnas, are ...
(Date:2/5/2016)... ... 2016 , ... The Lymphoma Research Foundation (LRF) – the ... the lymphoma community through a comprehensive series of education programs, outreach initiatives and ... Event at the La Gorce Country Club in Miami Beach on March 15, ...
(Date:2/5/2016)... ... February 05, 2016 , ... Regular gym users know the routine: each January, ... to access the treadmills. It’s a predictable trend. After the excesses of November and ... in shape by joining gyms, starting new walking or running routines, or signing up ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 2016 Wegener Polyangiitis - Pipeline Review, ... ,Wegener Polyangiitis - Pipeline Review, H2 2015, provides ... This report provides comprehensive information on the ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ...
(Date:2/4/2016)... Summary Breast cancer, a malignant neoplasm, ... common cancer in women worldwide, accounting for 16% of ... number of women diagnosed with breast cancer has increased ... deaths has declined due to earlier diagnosis and better ... in the past four decades, especially with increasing usage ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... Identifying and Commercializing First-in-Class Innovation ... disorder associated with chronic inflammation of the airways ... of COPD symptoms make the disease one of ... cause of death in the world. COPD is ...
Breaking Medicine Technology: