Navigation Links
Diabetes gene linked to degeneration of enzyme involved in Alzheimer's disease onset and progression
Date:10/12/2010

Mount Sinai School of Medicine researchers have found that a gene associated with the onset of Type 2 diabetes also is found at lower-than-normal levels in people with Alzheimer's disease. The research, led by Giulio Maria Pasinetti, MD, PhD, The Saunder Family Professor in Neurology, and Professor of Psychiatry and Geriatrics and Adult Development at Mount Sinai School of Medicine, was published this month in Aging Cell.

The new study provides insight into a potential mechanism that might explain the relationship between Type 2 diabetes and the onset and progression of Alzheimer's disease. Recent evidence indicates that healthy elderly subjects affected by Type 2 diabetes are twice as likely to develop Alzheimer's disease, but researchers have been unable to explain how.

"The relationship between Type 2 diabetes and Alzheimer's disease has been elusive," said Dr. Pasinetti. "This new evidence is of extreme interest, especially since approximately 60 percent of Alzheimer's disease cases have at least one serious medical condition primarily associated with Type 2 diabetes."

Using mice that were genetically engineered to have Alzheimer's disease comparable to that seen in humans, Dr. Pasinetti and colleagues found that a gene known as proliferator-activated receptor coactivator 1 (PGC-1), a key regulator of glucose currently investigated as a potential therapeutic target for Type 2 diabetes, is decreased in Alzheimer's disease. The team reports that this decrease might be causally linked to promotion of Alzheimer's disease. They found that PGC-1 promotes degradation of a specific enzyme known as beta-secretase (BACE). ACE is directly involved in the processing and eventually generation of β-amyloid, an abnormal protein highly linked to Alzheimer's disease and brain degeneration.

"Our research is the first to find that PGC-1 is a common denominator between Type 2 diabetes and Alzheimer's disease," said Dr. Pasinetti. "This discovery will have significant implications for the more than five million Americans affected by Alzheimer's disease, a number that is expected to skyrocket in the next three decades as the population ages. We look forward to continuing to research this discovery and translate it into the development of novel approaches for disease prevention and treatment."

Dr. Pasinetti and his colleagues are optimistic that if they find that PGC-1 can be manipulated pharmacologically to prevent BACE accumulation in the brain, these studies will provide important insights for the formulation of novel treatments and possible preventative strategies in Alzheimer's disease.


'/>"/>

Contact: Mount Sinai Press Office
newsnow@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. UT Southwestern study to determine whether leptin helps type 1 diabetes patients
2. Study links large waist size to higher diabetes rates among Americans
3. Patient-provider language barriers linked to worse diabetes control
4. Experts advocate realigning type 2 diabetes treatments with diseases natural history
5. Heart, kidney, diabetes and cancer MEP groups league against chronic disease to seek European commitment
6. Lifestyle intervention improves risk factors in type 2 diabetes
7. Type 1 diabetes research at UC San Diego gets $5 million boost
8. OHSU research team joins elite consortium dedicated to curing type 1 diabetes
9. Congressman to speak at meeting on diabetes and obesity
10. Drug holds promise to halt debilitating condition of diabetes
11. Immune System Genes Show Links to Type 1 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... August 21, 2017 , ... The American Hospital Association (AHA) ... a Highmark Health company, to its Board of Trustees for a three-year term beginning ... health care provider organizations and individuals that are committed to the improvement of health ...
(Date:8/21/2017)... ... August 21, 2017 , ... ... Group (NYSE: UNH), has made a multi-million dollar partnership commitment to support ... disorder (PTSD) and traumatic brain injuries (TBI) over the next year. , ...
(Date:8/20/2017)... ANGELES, Calif. (PRWEB) , ... August 20, 2017 , ... A total solar eclipse ... darken for a few minutes as the moon moves between the sun and Earth. This ... , These four tips can help keep you safe on the road during the ...
(Date:8/20/2017)... ... 20, 2017 , ... State Farm Neighborhood Assist® has named The Southern ... $25,000 grant. If the initiative wins, Gals Lead – Dream Queen Foundation’s signature teen ... area of St. Mary’s, Calvert and Charles Counties. The program could potentially impact nearly ...
(Date:8/19/2017)... ... August 19, 2017 , ... ... will feature the Aurum Group in an upcoming episode, slated to air fourth ... Innovations will feature the Aurum Group; a company committed to supporting dentistry using ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... Calif. , Aug. 2, 2017 ... Continental Who,s Who as a Pinnacle Lifetime Professional ... the Key Account Manager at Turing Pharmaceuticals, AG. ... negotiations, troubleshooting and relationship building.                ... has more than 25 years of experience as ...
(Date:7/31/2017)... Pharmacy, Inc. (NYSE: DPLO), has been named one of the ... Crain,s Detroit Business . The annual Crain,s Fast ... growth. This year,s edition measures growth from 2013 to 2016. ... list, visit crainsdetroit.com/awards/fast_50/2017 .  "Being named ... Phil Hagerman , CEO and chairman of Diplomat. "We,ve made ...
(Date:7/27/2017)... Holdings, Inc. (NYSE and SIX: ZBH) today reported financial results ... reported second quarter net sales of $1.954 billion, an ... an increase of 2.1% on a constant currency basis.  ... LDR Holding Corporation acquisition, second quarter 2017 revenues decreased ... on a constant currency basis. ...
Breaking Medicine Technology: