Navigation Links
Diabetes drug points the way to overcoming drug resistance in melanoma
Date:6/11/2013

Advanced metastatic melanoma is a disease that has proven difficult to eradicate. Despite the success of melanoma-targeting drugs, tumors inevitably become drug resistant and return, more aggressive than before. In the current issue of the journal Cancer Cell, however, researchers at The Wistar Institute describe how they increase the effectiveness of anti-melanoma drugs by combining anticancer therapies with diabetes drugs.

Their studies, conducted in cell and animal models of melanoma, demonstrate that the combined therapy could destroy a subset of drug-resistant cells within a tumor.

"We have found that the individual cells within melanoma tumors are not all identical, and tumors contain a sub-population of cells that are inherently drug resistant, which accounts for the fact that advanced melanoma tumors return no matter how much the tumor is depleted," said Meenhard Herlyn, D.V.M., D.Sc., professor and director of Wistar's Melanoma Research Center. "We found that these slow-growing, drug-resistant cells are marked by a high rate of metabolism, which makes them susceptible to diabetes therapeutics."

"Our findings suggest a simple strategy to kill metastatic melanomaregardless of cell type within the tumorby combining anticancer drugs with diabetes drug," Herlyn said. "The diabetes drug puts the brakes on the cells that would otherwise repopulate the tumor, thus allowing the anticancer drug to be more effective."

In the Cancer Cell article, the researchers describe how various anticancer drugs, including cisplatin and the targeted therapy vemurafenib, which targets melanomas with the BRAF mutation, become more effective when co-delivered with phenformin. According to Herlyn, the researchers used the diabetes drug phenformin in their studies, but they are now working with colleagues to develop a clinical trial using a drug with less toxic side effects.

Melanoma is the deadliest, most aggressive for
'/>"/>

Contact: Greg Lester
glester@wistar.org
215-898-3943
The Wistar Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. How a cancer drug leads to diabetes
2. Heart failure patients with diabetes may benefit from higher glucose levels
3. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
4. Mouse Study Hints at New Path for Diabetes Treatment
5. Common Plastics Chemical Might Boost Diabetes Risk
6. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
7. Naturopathic care can improve blood sugar, mood in diabetes
8. Cellular pathway linked to diabetes, heart disease
9. Diabetes Groups Issue New Guidelines on Blood Sugar
10. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
11. Xenotransplantation as a therapy for type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... “Many people become overwhelmed by the ... issues and phone calls with insurance companies,” The Jones ... their free eBook on pedestrian and bicycle accidents ... and bicycle auto accident claims assures the injured individual ... professionally handling their case while they focus on recovering. ...
(Date:12/26/2014)... PA (PRWEB) December 26, 2014 Pentec ... Work in the state of Pennsylvania for 2014. The ... first statewide programs of its kind in the country. ... Foundation, the Pennsylvania Department of Community and Economic Development, ... Resource Management and the Central Penn Business Journal. ...
(Date:12/26/2014)... 26, 2014 Parker & Sons, ... best in heating, cooling and plumbing contractor services ... emergency services in 2014 with regard to air-conditioning ... Arizona is known for its incredibly hot summers. ... the intricacies and details of a wide variety ...
(Date:12/25/2014)... 2014 This is a professional and ... Sterilizers industry with a focus on the Chinese market. ... of the Sterilizers manufacturers and is a valuable source ... in the industry. This report provides a basic overview ... technology. In this part, the report presents the company ...
(Date:12/25/2014)... 2014 The report “Nintedanib (Colorectal ... focuses on the current treatment landscape, unmet needs, ... cancer market. Stivarga is a drug which is ... cancer. Boehringer Ingelheim is developing nintedanib (BIBF-1120), an ... refractory CRC in the US, Europe, and Japan. ...
Breaking Medicine News(10 mins):Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4
... illness and death, study shows , TUESDAY, Oct. 13 ... a shorter life span, Australian researchers have found. , ... impairment with an increased risk of death from such ... index, slow walking speeds, a greater likelihood of falls, ...
... the technique, researchers say, but surgeon,s experience is key ... risks for post-operative incontinence and impotence may outweigh any ... a new study suggests. , The presumed good stemming ... public that is all too willing to believe, said ...
... long-term use, new review finds , TUESDAY, Oct. 13 (HealthDay ... phone-brain tumor connection finds a weak potential link between the ... topic, published online Oct. 13 in the Journal of ... spotlight was turned on only the more methodologically rigorous studies, ...
... cause trouble, so more study is needed, experts say , ... some old data adds convincing evidence that high body fluid ... of Parkinson,s disease. , However, the researchers also warned of ... , "The study doesn,t prove that urate is slowing down ...
... Oct. 13 In a recent survey of healthcare ... were more important to their organizations than they were ... of mobile productivity and management software, published a free ... for download at www.netmotionwireless.com/resources/whitepapers . , ...
... Hoag Hospital,s OB hospitalists provide immediate care onsite 24/7, ... BEACH, Calif., Oct. 13 Hoag is one of the ... Program in its labor and delivery unit. Hoag,s specialized program ... hospital 24 hours a day, seven days a week to ...
Cached Medicine News:Health News:Impaired Vision May Shorten Life Span 2Health News:Impotence, Incontinence Risk Casts Doubt on High-Tech Prostate Surgery 2Health News:Impotence, Incontinence Risk Casts Doubt on High-Tech Prostate Surgery 3Health News:Study Suggests Link Between Cell Phones and Brain Tumors 2Health News:Study Suggests Link Between Cell Phones and Brain Tumors 3Health News:Study Suggests Link Between Cell Phones and Brain Tumors 4Health News:Common Antioxidant Might Slow Parkinson's 2Health News:Common Antioxidant Might Slow Parkinson's 3Health News:NetMotion Wireless Publishes New Healthcare White Paper: Secure, Reliable Connections for Better Patient Care 2Health News:NetMotion Wireless Publishes New Healthcare White Paper: Secure, Reliable Connections for Better Patient Care 3Health News:Hoag OB Hospitalist Program Expands Exceptional Care for Pregnant and Laboring Women 2Health News:Hoag OB Hospitalist Program Expands Exceptional Care for Pregnant and Laboring Women 3
(Date:12/24/2014)... Dec. 23, 2014   Assurex Health, a ... to healthcare providers for behavioral health and chronic ... $30 million in equity financing from new and ... , President and Chief Executive Officer. ... development of Assurex Health,s GeneSight ® ...
(Date:12/24/2014)... 23, 2014 Tianyin Pharmaceutical Co., Inc. ... in patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), ... announced that the Company achieved the Public Notice ... (GMP) certificate of TPI,s Qionglai Facility (QLF) from ... public notice period is a significant procedure of ...
(Date:12/24/2014)... Dec. 23, 2014  Medical Science Liaisons play a ... link between the medical device industry and key stakeholders, ... the coming years as the device industry relies on ... to research by benchmarking firm, Best Practices, LLC, one ... important edge is by harnessing new technology to enable ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... Trial Raise Questions for,Patients, OAK BROOK, Ill., ... Trial, published in the September 18 issue of ... the technology,s,ability to diagnose intermediate- to large-sized polyps ... not as effective in diagnosing small polyps. CT,colonography ...
... Study Results Published in the September 18th New England ... die from colorectal cancer. Many,of these deaths could be ... 50 and older who should be screened for the ... cost, inconvenience, and safety,concerns associated with current screening exams., ...
Cached Medicine Technology:ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options 2ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options 3ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options 4ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options 5MultiVu Video Feed: Major Trial Demonstrates Comparable Accuracy of Virtual Colonoscopy and Standard Colonoscopy 2
Integrated electronics, three-chip CCD camera with PAL and NTSC output at 750 lines, RGB-video. 44mm x 49mm x 75mm, 180 grams....
Large image and wide-angle design....
High intensity halogen lamp with built-in, switchable spare. Optical light concentrator to optimize existing light energy....
PDA application listing specific ICD-9 coding listed in new Medicare National Coverage Determinations....
Medicine Products: