Navigation Links
Diabetes drug may prevent or delay development of polycystic ovary syndrome

Chevy Chase, MD A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) found that early, prolonged treatment with the diabetes drug metformin may prevent or delay the development of polycystic ovary syndrome (PCOS) in adolescence.

PCOS affects 7 to 10 percent of women of childbearing age and is the most common cause of infertility, affecting an estimated 5 to 6 million women in the United States, according to The Hormone Foundation.

"PCOS often presents in adolescence, with irregular menstrual cycles, acne, or too much body hair," said the study's senior author, Lourdes Ibez, MD, PhD, professor of pediatrics at the University of Barcelona in Spain and lead author of the study. "But we believe the critical years for PCOS development may be during childhood and puberty when excessive amounts of fat are stored. That excessive weight gain overexposes the ovaries to insulin, causing them to stop ovulating and start releasing male hormones, resulting in PCOS."

In this study of 38 girls with low birth-weight and early puberty, researchers compared the efficacy of early versus late metformin treatment to prevent adolescent PCOS. A group of 19 8-year-old girls were treated with daily doses of metformin for four years. A second group of 19 girls waited five years before they began receiving daily doses of metformin at age 13 and then continued treatment for only one year. They found that early metformin therapy prevented or delayed the development of hirsutism, androgen excess and PCOS more effectively than late metformin treatment.

"Metformin, when given across the potentially critical window of puberty, may have the capacity to reprogram metabolism toward less abdominal and liver fat," Ibez concluded. "In the years ahead, the focus of attention should shift from late treatment of PCOS and its complications, toward the early and large-scale prevention of PCOS, with measures such as diet, exercise and metformin in young girls."


Contact: Aaron Lohr
The Endocrine Society

Related medicine news :

1. Preventing Type 2 Diabetes Saves Money: Study
2. Trials of Type 1 Diabetes Vaccines Bring Mixed Results
3. Chemical produced in pancreas prevented and reversed diabetes in mice
4. Working Night Shifts May Raise Diabetes Risk for Women
5. Diabetes on Upswing Worldwide
6. Genetic study shows that low body fat may not lower risk for heart disease and diabetes
7. Massachusetts General Hospital, Iacocca Foundation announce promising results of Phase I diabetes trial
8. After Diabetes Diagnosis, Concentrate on Dietary Changes, Study Says
9. 350 million adults have diabetes: Study reveals the scale of global epidemic
10. Life expectancy for those with Type 1 diabetes improving, Pitt study says
11. Cautionary tale for people with diabetes: Dog consumed part of a sleeping patients toe
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton ... staged a mock evacuation of the facility as part of a disaster drill on ... Echo Hose EMS and Shelton City Emergency Manager, as well as the Connecticut ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains ... possible to save lost souls in the Philippines. “The Journey: From the Mountains to ... dedicated teacher of the Bible. She has taught all ages and currently teaches a ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
Breaking Medicine Technology: