Navigation Links
Diabetes drug may prevent or delay development of polycystic ovary syndrome
Date:6/29/2011

Chevy Chase, MD A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) found that early, prolonged treatment with the diabetes drug metformin may prevent or delay the development of polycystic ovary syndrome (PCOS) in adolescence.

PCOS affects 7 to 10 percent of women of childbearing age and is the most common cause of infertility, affecting an estimated 5 to 6 million women in the United States, according to The Hormone Foundation.

"PCOS often presents in adolescence, with irregular menstrual cycles, acne, or too much body hair," said the study's senior author, Lourdes Ibez, MD, PhD, professor of pediatrics at the University of Barcelona in Spain and lead author of the study. "But we believe the critical years for PCOS development may be during childhood and puberty when excessive amounts of fat are stored. That excessive weight gain overexposes the ovaries to insulin, causing them to stop ovulating and start releasing male hormones, resulting in PCOS."

In this study of 38 girls with low birth-weight and early puberty, researchers compared the efficacy of early versus late metformin treatment to prevent adolescent PCOS. A group of 19 8-year-old girls were treated with daily doses of metformin for four years. A second group of 19 girls waited five years before they began receiving daily doses of metformin at age 13 and then continued treatment for only one year. They found that early metformin therapy prevented or delayed the development of hirsutism, androgen excess and PCOS more effectively than late metformin treatment.

"Metformin, when given across the potentially critical window of puberty, may have the capacity to reprogram metabolism toward less abdominal and liver fat," Ibez concluded. "In the years ahead, the focus of attention should shift from late treatment of PCOS and its complications, toward the early and large-scale prevention of PCOS, with measures such as diet, exercise and metformin in young girls."


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Preventing Type 2 Diabetes Saves Money: Study
2. Trials of Type 1 Diabetes Vaccines Bring Mixed Results
3. Chemical produced in pancreas prevented and reversed diabetes in mice
4. Working Night Shifts May Raise Diabetes Risk for Women
5. Diabetes on Upswing Worldwide
6. Genetic study shows that low body fat may not lower risk for heart disease and diabetes
7. Massachusetts General Hospital, Iacocca Foundation announce promising results of Phase I diabetes trial
8. After Diabetes Diagnosis, Concentrate on Dietary Changes, Study Says
9. 350 million adults have diabetes: Study reveals the scale of global epidemic
10. Life expectancy for those with Type 1 diabetes improving, Pitt study says
11. Cautionary tale for people with diabetes: Dog consumed part of a sleeping patients toe
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... Sherly Sulaiman, ... a series of therapeutic sessions to help Los Angeles-area actors cope with rejection, ... lives. The series, known as “Mindfulness for Actors and Artists,” has been featured ...
(Date:2/10/2016)... ... February 10, 2016 , ... Western ... dental health services to the developmentally disabled in the Coachella Valley. , The ... a new facility at 71-949 Highway 111, Suite 100-B, in Rancho Mirage, California. ...
(Date:2/10/2016)... ... February 10, 2016 , ... Intermedix announced ... Emergency Medicine , an emergency medicine professional association, to support the organization's newly ... The American Academy of Emergency Medicine, or AAEM, seeks to empower emergency physicians ...
(Date:2/10/2016)... ... February 10, 2016 , ... 10 Best Water ... were three leading bottled water brand owners that topped the list as a result ... and optimize conversion. The premier brand was Tibet 5100, a top notch water company ...
(Date:2/10/2016)... ... 10, 2016 , ... Intalere’s 2016 Executive Forum, taking place ... the country’s top healthcare executives to share insights on transformational strategies to drive ... is the provider-centric perspective, experience, expertise and strategy shared by the participants,” said ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... and SAN DIEGO , Feb. ... a global leader in viral gene therapy manufacturing, and ... for congestive heart failure and other chronic diseases, have ... scalable manufacturing process and produce cGMP-grade RT-100 (Ad5.hAC6) Drug ... --> --> This ...
(Date:2/10/2016)... HILLS, Calif. , Feb. 10, 2016  Rich ... "Company") today announced a 1-for-100 reverse split of its ... the opening of trading on Thursday, February 11, 2016. ... basis under new CUSIP number 76303T308 and temporary ticker ... will commence trading under the ticker symbol (RCHA).  ...
(Date:2/10/2016)... -- The ALS Association, in partnership with ALS Finding a Cure, ... biomarker to track TDP43 aggregation. The successful team(s) with the ... investment. --> --> ... in the brain and the spinal cord. Eventually, people with ... which often leads to total paralysis and death within two ...
Breaking Medicine Technology: