Navigation Links
Diabetes drug halts atherosclerosis progression in HIV-infected patients
Date:3/7/2012

l levels and inflammatory factors.

A long-established treatment for type 2 diabetes, metformin is proven to reduce the incidence of cardiovascular disease associated with diabetes and is also used to treat insulin resistance caused by polycystic ovary syndrome. In 2000, Grinspoon led a pilot study finding that metformin reduced insulin levels in HIV patients with insulin resistance, abnormal fat distribution, and elevated cholesterol and triglyceride levels. The current study enrolled 50 participants receiving antiviral therapy for HIV infection and diagnosed with metabolic syndrome who were randomized into four groups. One group received standard daily doses of metformin and lifestyle modification classes; another received metformin only; a third received a placebo and lifestyle modification, and the fourth, placebo only.

At the end of the 12-month study period, participants taking metformin showed little change in coronary artery calcification a standard measure to assess atherosclerosis while those receiving neither intervention had an average calcium increase of 56 percent. Metformin treatment also reduced a standard measure of insulin resistance. Participation in the lifestyle modification sessions improved participants' physical fitness, dietary choices, and several cardiovascular-associated metabolic measures, but did not have a significant impact on coronary artery calcification.

"A recent report from a long-term study of cardiovascular risk factors in a non-HIV-infected population found that doubling of coronary artery calcium a 100 percent increase increased cardiac events by 26 percent," explains Grinspoon, who is a professor of Medicine at Harvard Medical School. "The more than 50 percent increase in coronary calcium in our participants who did not receive metformin supports the urgent need to develop strategies to slow the progression of atherosclerosis in HIV-infected patients with metabolic abnormalities. T
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Diabetes risk from sitting around
2. Stroke Risk Rises With Duration of Type 2 Diabetes: Study
3. Diabetes drug gets patients with Type 2 diabetes on target
4. Experimental Drug Shows Promise Against Type 2 Diabetes
5. Prediabetes Not to Blame for Nerve Damage: Study
6. Study finds some insulin production in long-term Type 1 diabetes
7. Type 1 Diabetes May Develop More Slowly Than Thought
8. As diabetes emerges, researchers track diseases first steps
9. Diabetes may start in the intestines, research suggests
10. When Mom Has Pregnancy Diabetes, Breast-Feeding Curbs Child Obesity
11. 4 New Genes Linked to Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... Carinsurancehints.com has released a new blog post explaining ... financial protection against fire damage. , Clients can now ... their vehicle is set intentionally on fire. This type of ... by other things. , It is possible to compare ... http://www.carinsurancehints.com/ , in just a few minutes. Clients ...
(Date:4/18/2015)... 18, 2015 Review of Ophthalmology magazine ... ‘Strategies for Success’ program for cataract surgeons attending the ... San Diego, where eye surgeon Jeffrey L. Martin, MD ... event. Dr. Martin is the Managing Partner of North ... chose Dr. Martin to lead this year’s discussion on ...
(Date:4/18/2015)... Lower-auto-insurance.com has released a new blog post explaining how ... , Drivers can find accurate information about various ... brokerage website can help drivers compare the newest and ... The whole process is designed to be convenient, free ... insurance quotes is advantageous because it allows clients to ...
(Date:4/18/2015)... the past few weeks, TheBeautyPlace.com has been undergoing maintenance ... run maintenance on our shipping facilities to update software ... Director. "It disrupted our regular shipping schedule but we ... track after having completed the maintenance." , Now, TheBeautyPlace.com ... has not allowed some calls to come in through ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Aureus ... healthcare staffing, including physical therapy jobs, has announced ... the South Carolina Physical Therapy Association Annual Conference ... Kroc Center in Greenville, SC. , The ... and exhibits with products and services. , ...
Breaking Medicine News(10 mins):Health News:Online Auto Insurance Quotes For Plans That Cover Fire Damages! 2Health News:Dr. Jeffrey Martin Invited to Share Latest Breakthroughs in Cataract Care During Roundtable Discussion at National 2015 ASCRS Meeting In San Diego 2Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:TheBeautyPlace.com Temporary Number Available 2Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2
... - Media representatives are invited to,attend a media conference ... Alan Trounson, President of the California Institute for,Regenerative Medicine ... CIRM and Dr. Martin Godbout, CEO of Genome Canada ... Consortium, to announce an international,collaboration on cancer stem cell ...
... 18 Movement Against Cancer,(MAC), cancer patient advocacy group ... people in Russia to undergo early screening,tests and diagnostic ... cancer and cervical cancer -- the types of cancer,that ... the most serious problems with cancer treatment in Russia ...
... faster course of disease, researchers say , , WEDNESDAY, June ... disease also plays a role in HIV progression by ... say. , "The apoE4 protein is the greatest ... role in infectious diseases has been less well-defined," study ...
... Drug Administration (FDA) has approved the NeuRx Diaphragm Pacing ... on ventilators for breathing. The light-weight, battery-powered electronic ... while eliminating the need for a power source and ... developed over the course of 20 years through a ...
... Manages Over 150,000 Identities, ANDOVER, Mass., June ... six months, seven healthcare organizations have selected,Sentillion,s proVision ... eliminate the challenges of manual user account,management, including:, ... -- Baptist Health System (Birmingham, AL) ...
... increased risk of developing asthma compared to babies born naturally. ... shown in a new study based on data from 1.7 ... Norwegian Institute of Public Health. , The goal of ... born by Caesarean section and later development of asthma. ...
Cached Medicine News:Health News:Movement Against Cancer Launches An All-Russia Cancer Awareness Campaign to Promote Early Screening and Cancer Detection Programs in Russia's Regions 2Health News:Alzheimer's Protein Tied to HIV Progression 2Health News:FDA approves NeuRx diaphragm pacing system for use in spinal cord- injured patients 2Health News:Leading Healthcare Organizations Overwhelmingly Select Sentillion for User Provisioning 2Health News:Leading Healthcare Organizations Overwhelmingly Select Sentillion for User Provisioning 3Health News:Caesarean sections associated with risk of asthma 2
(Date:4/17/2015)... ASSESS shows   plasma circulating ... viable alternative to tumour biopsy   IGNITE ... advanced NSCLC   AstraZeneca today presented results from ... DNA (ctDNA) testing for epidermal growth factor receptor (EGFR) mutation ... cancer (NSCLC) in clinical practice. [ 1 ] ...
(Date:4/17/2015)... DETROIT , April 17, 2015  In ... poverty, the infant mortality rate is two and one half ... live births. Nearly 6 of 10 infants that die in ... care.  These are sobering statistics that Covenant Community Care, a ... Metro Detroit, is poised to change thanks to a charitable ...
(Date:4/17/2015)... Research and Markets ( http://www.researchandmarkets.com/research/5hkm2f/medical_oxygen ) ... Systems - Global Strategic Business Report" report to ... markets for Medical Oxygen Systems in US$ Thousands by ... Cylinders & Regulators, and Oxygen Conserving Devices. The report ... Canada , Japan , ...
Breaking Medicine Technology:"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 2"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 3"Real World" Data Support Use of Blood Test for EGFR Mutation in Advanced NSCLC 4Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 2Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 3Covenant Community Care to Receive Donated SONIMAGE P3 Handheld Ultrasound from Konica Minolta Medical Imaging 4Medical Oxygen Systems - 2015 Global Strategic Business Report Featuring Leading Players, Caire, Invacare & Philips Respironics 2
12 mm diameter pigtail curved probes with eyes 4mm back of blunt ends. Stainless steel. Round knurled handle with polished finish. Overall length: 5.9 inches....
Yag Laser System SYL is compact and light-weight. It is CE Mark approved according to MDD....
Practice-oriented ophthalmic laser systems for photodisruption....
Desmarres Chalazion Clamps, large....
Medicine Products: