Navigation Links
Diabetes drug halts atherosclerosis progression in HIV-infected patients
Date:3/7/2012

l levels and inflammatory factors.

A long-established treatment for type 2 diabetes, metformin is proven to reduce the incidence of cardiovascular disease associated with diabetes and is also used to treat insulin resistance caused by polycystic ovary syndrome. In 2000, Grinspoon led a pilot study finding that metformin reduced insulin levels in HIV patients with insulin resistance, abnormal fat distribution, and elevated cholesterol and triglyceride levels. The current study enrolled 50 participants receiving antiviral therapy for HIV infection and diagnosed with metabolic syndrome who were randomized into four groups. One group received standard daily doses of metformin and lifestyle modification classes; another received metformin only; a third received a placebo and lifestyle modification, and the fourth, placebo only.

At the end of the 12-month study period, participants taking metformin showed little change in coronary artery calcification a standard measure to assess atherosclerosis while those receiving neither intervention had an average calcium increase of 56 percent. Metformin treatment also reduced a standard measure of insulin resistance. Participation in the lifestyle modification sessions improved participants' physical fitness, dietary choices, and several cardiovascular-associated metabolic measures, but did not have a significant impact on coronary artery calcification.

"A recent report from a long-term study of cardiovascular risk factors in a non-HIV-infected population found that doubling of coronary artery calcium a 100 percent increase increased cardiac events by 26 percent," explains Grinspoon, who is a professor of Medicine at Harvard Medical School. "The more than 50 percent increase in coronary calcium in our participants who did not receive metformin supports the urgent need to develop strategies to slow the progression of atherosclerosis in HIV-infected patients with metabolic abnormalities. T
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Diabetes risk from sitting around
2. Stroke Risk Rises With Duration of Type 2 Diabetes: Study
3. Diabetes drug gets patients with Type 2 diabetes on target
4. Experimental Drug Shows Promise Against Type 2 Diabetes
5. Prediabetes Not to Blame for Nerve Damage: Study
6. Study finds some insulin production in long-term Type 1 diabetes
7. Type 1 Diabetes May Develop More Slowly Than Thought
8. As diabetes emerges, researchers track diseases first steps
9. Diabetes may start in the intestines, research suggests
10. When Mom Has Pregnancy Diabetes, Breast-Feeding Curbs Child Obesity
11. 4 New Genes Linked to Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Dennis Thompson HealthDay Reporter ... first confirmed case of Ebola has surfaced in the United ... federal health officials announced late Tuesday. The critically ill ... Dallas, has been diagnosed with the deadly virus, officials ... in a late afternoon news conference. The man is ...
(Date:9/30/2014)... Health Day Reporter TUESDAY, ... who are overweight or obese when diagnosed appear to ... weight-related cancer, new research suggests. , , The finding ... only the potential for developing other cancers associated with ... who reported being overweight or obese prior to diagnosis ...
(Date:9/30/2014)... in 2003 to slow the spiraling costs of drugs ... patients has had no meaningful impact on cancer chemotherapy ... Journal of Clinical Oncology published online today. ... treat colorectal and lung cancers, and did not find ... following the implementation of the recent Medicare law in ...
(Date:9/30/2014)... Sept. 30, 2014 Research by UC Irvine immunologists ... shedding light on a vital process that determines how ... the online version of Nature Immunology , neurology ... other Institute for Immunology colleagues describe a critical mechanism ... into the bloodstream. , A T cell is a ...
(Date:9/30/2014)... Las Vegas, NV (PRWEB) September 30, 2014 ... by certified nutrition specialist and best-selling author Mike Geary that ... and totally transform their body into a fat-burning machine in ... Michaels, prompting an investigative review. , “In our culture ... it can be hard to decipher what is really fact ...
Breaking Medicine News(10 mins):Health News:CDC Confirms First Patient Diagnosed With Ebola in United States 2Health News:CDC Confirms First Patient Diagnosed With Ebola in United States 3Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 3Health News:Landmark Medicare law had little impact on reducing chemotherapy cost 2Health News:UCI study uncovers important process for immune system development 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 2Health News:Fat Burning Kitchen: Review Exposes Mike Geary’s 24-Hour Diet Transformation for Helping the Body Burn Fat Through a Natural Diet 3
... risk of developing obesity. In the current issue of ... colleagues from Witten/Herdecke University describe possible ways to prevent ... 268-75). , There are many reasons that a ... the disability itself, for example, if this includes the ...
... ... Your Story” Diamond Contest. Shenoa will give away a 1-carat diamond ... to win the diamond contestants need only write a short story. Consumer ... is a way to show consumers they are appreciated by Shenoa. ...
... new study shows that a family of molecules called ... many important functions in healthy cells, but that in ... , The research, led by scientists at the Ohio ... and Richard J. Solove Research Institute in collaboration with ...
... mysteries of the animal world: why do females change the ... all year round? Researchers at the University of Gothenburg, Sweden, ... found some of the answers. What can millimetre-long water ... south-west Sweden have to say about animals, winter and summer ...
... from seven founding universities of the Global Alliance of ... at Shanghai Jiao Tong University to hold the 2010 ... Sustainable Urban Solutions. The latter coincides with ... Better Life. Senior representatives discussed the role of technological ...
... parents need more help with lifesaving drug regimens, study ... new study suggests that parents often make mistakes when ... , "Giving these medicines in exactly the right way ... conditions," said study lead author Dr. Kathleen E. Walsh, ...
Cached Medicine News:Health News:ShenoaDiamonds.com Holds Contest to Give Away $5,000 Diamond Ring, Spurred by Online Sales Growth 2Health News:Cancer cells show rewired, fragmented microRNA networks 2Health News:Large caps this spring's must-have for water fleas 2Health News:Global Alliance of Technological Universities (GlobalTech) to tackle 'Grand Challenges' 2Health News:Parent Error Common When Medicating Chronically Ill Kids 2
(Date:9/30/2014)... -- The Eastern European medical device industry is in ... as new medical-device manufacturers are constantly trying to penetrate ... to reduce the cost incurred for placing their products ... effective means to achieve this target. This research service ... and provides profiles of key distributors in ...
(Date:9/30/2014)... , Sept. 30, 2014 Passport Health, ... America , has launched FluFree.com, a website designed ... vaccinations. For 20 years, Passport Health has ... the flu. The launch of FluFree.com is designed to ... and the number of people who actually chose to ...
(Date:9/30/2014)... Ind. , Sept. 30, 2014  The orthopedic specialists ... the nation,s No. 6 orthopedic group by US News ... Active Adults," a series of free, public seminars to ... all over the world come to see the knee ... procedures are now available at Munster Specialty Surgery Center. ...
Breaking Medicine Technology:Medical Technologies Distributor Profiles in Eastern Europe 2Medical Technologies Distributor Profiles in Eastern Europe 3Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 2Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 3"Knee Pain Solutions for Active Adults" Complimentary Seminars Open to the Public 2
... 2011 Actavis, an international generic pharmaceutical company, today ... Extended-Release Tablets, a generic equivalent of Keppra XR®.  Shipping ... US total sales of approximately $161 million for the ... Health.   About Actavis: ...
... iKnowMed Electronic Health Record System (EHR) ... McKesson Specialty Health Solutions for Oncology , ... comprehensive chemotherapy orders workflow management system. Oncologists with both products ... which now automatically communicates with Lynx Mobile. This way, when ...
Cached Medicine Technology:Actavis Launches Generic Keppra XR® Tablets in the U.S. 2iKnowMed™ Integrates with Lynx Mobile® to Advance a Comprehensive Chemotherapy Management System 2iKnowMed™ Integrates with Lynx Mobile® to Advance a Comprehensive Chemotherapy Management System 3
The Optima III line of laparoscopic hand instruments provides a well-crafted set of instruments designed for strength and durability....
Inquire...
For use with Snap-In Snap-Out-II tip inserts. Available in five styles, the Snap-In Snap-Out-II Laparoscopic Instrument Handles offer the broadest range available....
Inquire...
Medicine Products: