Navigation Links
Diabetes drug halts atherosclerosis progression in HIV-infected patients
Date:3/7/2012

l levels and inflammatory factors.

A long-established treatment for type 2 diabetes, metformin is proven to reduce the incidence of cardiovascular disease associated with diabetes and is also used to treat insulin resistance caused by polycystic ovary syndrome. In 2000, Grinspoon led a pilot study finding that metformin reduced insulin levels in HIV patients with insulin resistance, abnormal fat distribution, and elevated cholesterol and triglyceride levels. The current study enrolled 50 participants receiving antiviral therapy for HIV infection and diagnosed with metabolic syndrome who were randomized into four groups. One group received standard daily doses of metformin and lifestyle modification classes; another received metformin only; a third received a placebo and lifestyle modification, and the fourth, placebo only.

At the end of the 12-month study period, participants taking metformin showed little change in coronary artery calcification a standard measure to assess atherosclerosis while those receiving neither intervention had an average calcium increase of 56 percent. Metformin treatment also reduced a standard measure of insulin resistance. Participation in the lifestyle modification sessions improved participants' physical fitness, dietary choices, and several cardiovascular-associated metabolic measures, but did not have a significant impact on coronary artery calcification.

"A recent report from a long-term study of cardiovascular risk factors in a non-HIV-infected population found that doubling of coronary artery calcium a 100 percent increase increased cardiac events by 26 percent," explains Grinspoon, who is a professor of Medicine at Harvard Medical School. "The more than 50 percent increase in coronary calcium in our participants who did not receive metformin supports the urgent need to develop strategies to slow the progression of atherosclerosis in HIV-infected patients with metabolic abnormalities. T
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Diabetes risk from sitting around
2. Stroke Risk Rises With Duration of Type 2 Diabetes: Study
3. Diabetes drug gets patients with Type 2 diabetes on target
4. Experimental Drug Shows Promise Against Type 2 Diabetes
5. Prediabetes Not to Blame for Nerve Damage: Study
6. Study finds some insulin production in long-term Type 1 diabetes
7. Type 1 Diabetes May Develop More Slowly Than Thought
8. As diabetes emerges, researchers track diseases first steps
9. Diabetes may start in the intestines, research suggests
10. When Mom Has Pregnancy Diabetes, Breast-Feeding Curbs Child Obesity
11. 4 New Genes Linked to Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... California (PRWEB) January 22, 2015 The City of ... at 10 a.m., to commemorate the 42nd anniversary of the Supreme ... States. , “It’s been 42 years since the Roe vs. Wade ... is still as present as ever,” said City of West Hollywood ...
(Date:1/22/2015)... 2015 Padre Murphy's and Owner Tom Boyle ... Pro Player Health Alliance (PPHA). The PPHA's passion for ... everyone, including NFL greats, treated for obstructive sleep apnea (OSA) ... supporting the cause in the valley. The most recent plans ...
(Date:1/22/2015)... Angelweddingdress is a famous wedding dress company ... to follow it on Facebook, Twitter, and Pinterest. The fans ... Angelweddingdress draws a lottery every week. , Moreover, the company ... 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 The federal court ... the U.S. District Court, Southern District of West Virginia has ... in that proceeding’s first bellwether trial. In an Order dated ... new trial after finding that C.R. Bard had not proven ...
(Date:1/22/2015)... York (PRWEB) January 22, 2015 Thousand ... Fresenius Medical Care recalled its GranuFlo and NaturaLyte dialysis ... litigation underway in U.S. District Court, District of Massachusetts, ... January 20th, the Court has remanded a case filed ...
Breaking Medicine News(10 mins):Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4
... North American Insurance,Leaders, Inc. (Amex: NAO ), ... Deep South Companies ("Deep South") for 2007 Governing EBITDA ... subject to review by,NAO upon the receipt of audited ... that the Governing EBITDA will fall within a,range from ...
... impact on counseling and genetic testing, study shows ... of relatives to discuss a family,s cancer history has ... and testing among women at moderate risk for breast ... research found that black women are less likely ...
... Winners Named in Three Categories: Sustainable Technology, Life Sciences, ... ... The winners of the 2008 McGinnis,Venture Competition, which awarded more ... Tepper School of Business at,Carnegie Mellon University, Yale University and the ...
... addresses by Linda Ellerbee, award-winning,journalist/television producer; and ... chairman, RealAge, Inc., ORLANDO, Fla., March ... URAC:, (Logo: http://www.newscom.com/cgi-bin/prnh/20030501/URACLOGO ), ... accreditor which,offers more than 20 accreditation and ...
... for Cardiothoracic Surgery in Great Britain & Ireland (published ... recorded the variations in activity and surgical approaches between ... Presented at the recent Annual Meeting of the Society ... Scotland), The First National Thoracic Database Report 2008, is ...
... STROUDSBURG, Pa., March 21 In two weeks, on April,4, ... the year,with numerous spa discounts. During the ten-day periods of ... can stay ten days for the price of one,week and ... the five-night Mini-Week in between -- from April 13 to ...
Cached Medicine News:Health News:North American Insurance Leaders, Inc. Receives an Estimate of Deep South 2007 Governing EBITDA 2Health News:Family Discussion Plays Role in Breast Cancer Awareness 2Health News:Teams From Carnegie Mellon, Yale, Manitoba Win Tepper School's 2008 McGinnis Venture Competition 2Health News:Winners of Best Practices in Consumer Empowerment and Protection Awards to be Announced at Conference 2Health News:New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland 2Health News:New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland 3Health News:New report highlights variations in approaches to thoracic surgery in the United Kingdom and Ireland 4Health News:Deerfield Spa, Voted Among 'Best Affordable Spas,' Opens 2008 Season With Discounts, Savings, Gifts, Specials 2
(Date:1/23/2015)... 23, 2015  Now available for sale, The Armor1 Ankle ... prevents ankle sprains by cushioning the ankle from an ... around the outside of any shoe type and allows ... still offering protection against sprains. With customers in physical ...
(Date:1/23/2015)... JUNCTION, N.J. , Jan. 23, 2015  CytoSorbents ... company commercializing its CytoSorb® extracorporeal cytokine adsorber to ... patients, announced the receipt of $385,642, net of ... participant of the Technology Business Tax Certificate Transfer ...
(Date:1/22/2015)... a privately held medical device company, announced today that ... ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to sell ... cancer in Japan . ViewRay,s technology, ... only MRI-guided radiation therapy system that images and treats ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
Hand surgery basic instrument set...
Castroviejo caliper...
Microscopic scissors, curved...
Velcro closures on each side to more evenly distribute the weight. Available in teal, royal, red, purple, or maroon nylon stain-resistant fabric or navy nylon reinforced vinyl....
Medicine Products: