Navigation Links
Diabetes drug could treat leading cause of blindness
Date:5/7/2012

University of Texas Medical Branch at Galveston researchers have discovered that a drug already prescribed to millions of people with diabetes could also have another important use: treating one of the world's leading causes of blindness.

In laboratory rat and cell-culture experiments, the scientists found that metformin, which is commonly used to control blood sugar levels in type 2 diabetes, also substantially reduced the effects of uveitis, an inflammation of the tissues just below the outer surface of the eyeball. Uveitis causes 10 to 15 percent of all cases of blindness in the United States, and is responsible for an even higher proportion of blindness globally. The only treatment now available for the disorder is steroid therapy, which has serious side effects and cannot be used long-term.

"Uveitis has various causes the most common are infectious diseases and autoimmune disorders but they all produce inflammation within the eye," said UTMB professor Kota V. Ramana, senior author of a paper on the study now online in the journal Investigative Ophthalmology & Visual Science. "Metformin inhibits the process that causes that inflammation."

The scientists discovered metformin's efficacy when they tested it in rats given an endotoxin that mimicked the inflammatory effects of bacterial infection. The results showed clearly that metformin was a very effective anti-uveitis agent.

"We found that the drug is therapeutic as well as preventive if we gave our rats the drug beforehand, they didn't develop uveitis, and if we gave it after uveitis had developed, it was therapeutic," said UTMB professor Satish Srivastava, also an author of the IOVS paper. "Metformin's strong anti-inflammatory properties make this possible."

According to the researchers, metformin works by activating an enzyme called AMPK, which in turn damps down the activity of the protein NF-kappa B. The inhibition of NF-kappa B suppresses the production of inflammatory signaling molecules cytokines and chemokines needed to initiate and sustain uveitis.

Because metformin is already used so widely as a therapy for diabetes, the UTMB scientists believe that it has a good chance of being rapidly adopted as an anti-uveitis drug.

"I think after a few more pre-clinical studies are done, we can get this drug to patients in a shorter time than usual," Ramana said. "Its safety is already known, so all that we need to see is its efficacy in humans."


'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Study identifies possible protective blood factors against Type 2 diabetes
2. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
3. Xenotransplantation as a therapy for type 1 diabetes
4. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
5. Diabetes Groups Issue New Guidelines on Blood Sugar
6. Cellular pathway linked to diabetes, heart disease
7. Naturopathic care can improve blood sugar, mood in diabetes
8. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
9. Common Plastics Chemical Might Boost Diabetes Risk
10. Mouse Study Hints at New Path for Diabetes Treatment
11. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... Splashtop Inc., ... its strategic partnership with e-Jan Networks Co., the leading provider of secure mobile ... customers of e-Jan Networks’s leading CACHATTO remote access solution. Splashtop for ...
(Date:5/31/2016)... ... May 31, 2016 , ... Twenty years ago it was revolutionary: enabling the ... silence the voices they hear. But this approach has proven transformative, both for people ... steadily gained credibility and now is used around the world, but it still lags ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... Corporation, he knew it was something that contractors should have at their disposal ... it gets,” says Butch, CertainTeed’s Director of Contractor Programs. , As a ...
(Date:5/31/2016)... ... May 31, 2016 , ... CallTrackingMetrics's software gives ... monitor the performance of sales and support staff, and to efficiently route calls ... allows customers to record, transcribe, route, document, and report on everything going on ...
(Date:5/31/2016)... Newport Beach, Calif. (PRWEB) , ... May 31, 2016 , ... ... trust among colleagues, clients, and the industry as a whole. On June 2, Northbound ... Coast Symposium on Addictive Disorders (WCSAD) and presenting the opening plenary on “Leadership: The ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... VALLEY COTTAGE, New York , May 31, 2016 ... traction as an essential ingredient in food, cosmetics and ... 2016 end, representing revenues worth US$ 1.6 Bn. ... vera gels, cosmetics products, juices, and yogurts will continue ... health and wellness trend will also boost positive sentiment ...
(Date:5/31/2016)... May 31, 2016 , Isansys  Lifecare, ... its Patient Status Engine wireless patient monitoring platform, as it ... Germany , Scotland and ... 2 nd generation system, launched earlier this year, is now ... , , This new technology significantly enhances ...
(Date:5/30/2016)... , May 30, 2016 ... report "Healthcare Biometrics Market by Technology (Single-factor ... Multifactor, Multimodal), Application (Workforce Management), End User ... 2021", published by MarketsandMarkets, the market is ... 2021 from USD 1,182.6 Million by 2016, ...
Breaking Medicine Technology: