Navigation Links
Diabetes drug could treat leading cause of blindness
Date:5/7/2012

University of Texas Medical Branch at Galveston researchers have discovered that a drug already prescribed to millions of people with diabetes could also have another important use: treating one of the world's leading causes of blindness.

In laboratory rat and cell-culture experiments, the scientists found that metformin, which is commonly used to control blood sugar levels in type 2 diabetes, also substantially reduced the effects of uveitis, an inflammation of the tissues just below the outer surface of the eyeball. Uveitis causes 10 to 15 percent of all cases of blindness in the United States, and is responsible for an even higher proportion of blindness globally. The only treatment now available for the disorder is steroid therapy, which has serious side effects and cannot be used long-term.

"Uveitis has various causes the most common are infectious diseases and autoimmune disorders but they all produce inflammation within the eye," said UTMB professor Kota V. Ramana, senior author of a paper on the study now online in the journal Investigative Ophthalmology & Visual Science. "Metformin inhibits the process that causes that inflammation."

The scientists discovered metformin's efficacy when they tested it in rats given an endotoxin that mimicked the inflammatory effects of bacterial infection. The results showed clearly that metformin was a very effective anti-uveitis agent.

"We found that the drug is therapeutic as well as preventive if we gave our rats the drug beforehand, they didn't develop uveitis, and if we gave it after uveitis had developed, it was therapeutic," said UTMB professor Satish Srivastava, also an author of the IOVS paper. "Metformin's strong anti-inflammatory properties make this possible."

According to the researchers, metformin works by activating an enzyme called AMPK, which in turn damps down the activity of the protein NF-kappa B. The inhibition of NF-kappa B suppresses the prod
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study identifies possible protective blood factors against Type 2 diabetes
2. New research finds no association between white potato consumption (baked, boiled mashed) and obesity, Type 2 diabetes or systemic inflammation
3. Xenotransplantation as a therapy for type 1 diabetes
4. Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
5. Diabetes Groups Issue New Guidelines on Blood Sugar
6. Cellular pathway linked to diabetes, heart disease
7. Naturopathic care can improve blood sugar, mood in diabetes
8. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
9. Common Plastics Chemical Might Boost Diabetes Risk
10. Mouse Study Hints at New Path for Diabetes Treatment
11. Disrupted Sleep May Raise Risk for Obesity, Diabetes: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... (PRWEB) June 03, 2015 Come on ... Relay , a 200-mile overnight relay beginning in Madison, ... Illinois on Saturday, June 13th. , For the 4th ... the Brainstormers will run to raise money for the ... of different members of the Neurosurgery staff from The ...
(Date:6/3/2015)... Israel (PRWEB) June 03, 2015 evigilo, ... multi-channel solutions, has showcased its new branding by launching ... , "The new brand identity: the logo depicting ... red, to green, the tagline – To Know. To ... new path evigilo is charting. A global, borderless approach ...
(Date:6/2/2015)... The JK-A0100EU secure smart card keyboard ... finance and healthcare. However, this keyboard can also be ... to enhance the security of their network. , The ... of a Smart Card before allowing access to the ... reader, the keyboard supports secure PIN entry. , The ...
(Date:6/2/2015)... MEDIA ADVISORY, June 2, 2015 ... Email: ewallace(at)mentalhealthamerica(dot)net , Breaking News: Congressman Tim Murphy ... at MHA Annual Conference Thursday , Who: Congressman ... address the Mental Health America Annual Conference attendees ... of the Helping Families in Mental Health Crisis ...
(Date:6/2/2015)... Highly qualified dental care specialists inside the leading ... change in the dental tourism industry in Europe. As dentistry ... offers a full range of superior dental services in its ... , Partnered with a top medical tourism agency , ... and has earned a reputation as an influential provider for ...
Breaking Medicine News(10 mins):Health News:4th Annual Ragnar Relay from Madison, WI to Chicago, IL Once Again Benefits Renowned Brain Aneurysm Foundation 2Health News:Keep calm! evigilos' "sun" will come out tomorrow – to know, to act, in time. 2Health News:Introducing the New CHERRY JK-A0100EU Keyboard with Integrated Smart Card Reader for Access Control Security 2Health News:Congressman Tim Murphy to Unveil Details of New Mental Health Legislation at MHA Annual Conference Thursday 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 3
... a platinum-based anticancer drug that,s made enormous headway in ... damage that may be permanent and worsens even months ... Johns Hopkins researchers in the September issue of ... be the first effort to track oxaliplatin-based nerve damage ...
... Serena Gordon HealthDay Reporter , TUESDAY, Sept. 27 ... screening earlier than women, new research suggests. The study ... precancerous lesions (also called polyps or adenomas) in their colon ... women -- and to have them at an earlier age. ...
... habits of a romantic partner,s friends are more likely to ... an adolescent,s own friends or significant other, according to a ... Review. "Dating someone whose friends are big drinkers is ... drinking behaviors than are the drinking habits of the adolescent,s ...
... on aging are headed for meetings with their senators ... senior population, spurred by the first-ever Take Action Week ... nation,s largest interdisciplinary organization devoted to the field of ... period, these advocates will urge their elected leaders to ...
... JOLLA, CA -- September 27, 2011 -- Scripps Research ... $3.6 million MERIT (Method to Extend Research in Time) ... to study the risk factors for alcoholism in Native ... to better understand alcohol dependence and alcohol-related problems in ...
... Reporter , TUESDAY, Sept. 27 (HealthDay News) -- Many ... when the going gets slow, fiber seems to beat ... suggests. A review of nine studies with 640 ... has no known physical cause, found that fiber supplements ...
Cached Medicine News:Health News:Popular colorectal cancer drug may cause permanent nerve damage 2Health News:Do Men Need Colon Cancer Screening Earlier Than Women Do? 2Health News:Do Men Need Colon Cancer Screening Earlier Than Women Do? 3Health News:Adolescents particularly susceptible to drinking habits of romantic partner's friends 2Health News:Congress must protect funds for aging America, advocates say 2Health News:Scripps research scientist wins $3.6 million NIH Method to Extend Research in Time award to study alcoholism in Native Americans 2Health News:Fiber Beats Other Remedies for Constipated Kids, Study Says 2Health News:Fiber Beats Other Remedies for Constipated Kids, Study Says 3
(Date:6/2/2015)... STATESVILLE, N.C. , June 2, 2015 ... its Board of Directors declared a quarterly cash dividend ... 26, 2015 to stockholders of record at the close ... About Kewaunee Scientific Founded in 1906, Kewaunee ... design, manufacture, and installation of laboratory, healthcare, and technical ...
(Date:6/2/2015)... PAUL, Minn., June 2, 2015  MGC Diagnostics ... technology company, today reported financial results for the ... , 2015 second quarter domestic equipment, supplies and ... were flat at $4.2 million.  During the quarter, ... in revenue, compared to 12 accounts, or $850,000 ...
(Date:6/2/2015)... , June 2, 2015 REPORT ... was at nearly $3.7 billion in 2013. This market is ... to nearly $7.8 billion in 2019, with compound annual growth ... to 2019. This report provides: An ... lasers.Analyses of global market trends, with data from 2013, estimates ...
Breaking Medicine Technology:MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 2MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 3MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 4MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 5MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 6MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 7MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 8MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 9MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 10MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 11MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 12MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 13MGC Diagnostics Corporation Reports Fiscal 2015 Second Quarter Results 14Global Markets and Technologies for Medical Lasers 2
... Transplant Opportunity of Over $400 Million ... ... ) today announced that its second phase 3 trial of Mozobil(TM),(plerixafor) has ... (MM) similar to those,reported two weeks ago in non-Hodgkin,s lymphoma. The ...
... Society,for Therapeutic Radiology and Oncology has published the ... to assist people coping with,Hodgkin,s and non-Hodgkin,s lymphoma. ... explains radiation therapy,s role in,treatment and what patients ... "A cancer diagnosis can be very frightening and ...
Cached Medicine Technology:Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint 2Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint 3Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint 4Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint 5Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint 6Genzyme Announces Second Pivotal Mozobil Trial Meets Primary Endpoint 7
... A lower cost alternative to Equalizers, the ... transfers between two different vessel configurations. With the ... can be quickly and easily adjusted for test ... Ergonomic Design for Unparalleled Comfort Pick ...
... Expandable Tip System A lower cost alternative ... to perform multi-sample transfers between two different vessel ... knob, tip spacing can be quickly and easily ... 96 well plates. Ergonomic Design for Unparalleled ...
... Well Plate Capability The Equalizer 384 ... Equalizerexpandable and equal tip spacing, choice of two ... In addition, this model allows you to evenly ... and accessing many gels and for use with ...
... With 384 Well Plate Capability The ... the original Equalizerexpandable and equal tip spacing, choice ... calibration capabilities. In addition, this model allows you ... for loading and accessing many gels and for ...
Medicine Products: