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Diabetes drug could hold promise for lung cancer patients
Date:1/29/2013

f an issue for most cancer patients. The issue of kidney toxicity would also be bypassed in cancer patients because the course of treatment is much shorter, measured in weeks to months compared to years of treatment for diabetes patients.

The next step is to determine if phenformin alone would be a sufficient therapy for certain subsets of NSCLC or if the drug would perform better in combination with existing cancer drugs. Based on their findings, the researchers say that phenformin would be most useful in treating early-stage LKB1-mutant NSCLC, as an adjuvant therapy following surgical removal of a tumor, or in combination with other therapeutics for advanced tumors.

"The good news," says Shackelford, "is that our work provides a basis to initiate human studies. If we can organize enough clinicians who believe in investigating phenforminand many dothen phenformin as an anti-cancer agent could be a reality in the next several years."


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Contact: Andy Hoang
AHoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

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