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Diabetes doubles liver cancer risk for patients with advanced hepatitis C
Date:5/29/2008

without diabetes developed hepatocellular carcinoma. The 5-year occurrence was 11.4 percent and 5.0 percent, respectively. Male gender and older age were significantly associated with elevated HCC risk. In addition, there was a strong trend towards a higher incidence of HCC among patients with diabetes mellitus, the authors report. Multivariate Cox regression analysis of patients with Ishak 6 cirrhosis showed that diabetes was independently associated with the development of HCC.

Interestingly, among patients with diabetes, there was a trend towards higher risk of HCC as fasting glucose levels increased. The authors hypothesize that resulting hyperinsulinemia might help explain the increased risk of HCC among diabetic patients.

Whatever the mechanism, the risk is clear. For patients with chronic hepatitis C and advanced cirrhosis, diabetes mellitus increases the risk of developing HCC, the authors conclude.


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Contact: Sean Wagner
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Source:Eurekalert

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