Navigation Links
Diabetes and Elevated Levels of Cholesterol Linked to Faster Cognitive Decline in Alzheimer's Patients
Date:3/6/2009

Heart Disease and Stroke Linked to Increased Cognitive Decline only in Alzheimer's Patients who carry the APOE-µ4 Gene - Previously Implicated in Late-Onset Disease

New York -- A history of diabetes and elevated levels of cholesterol, especially LDL cholesterol, are associated with faster cognitive decline in patients with Alzheimer's disease, according to a new study from Columbia University Medical Center researchers. These results add further evidence of the role of vascular risk factors in the onset and progression of Alzheimer's disease.

The study will be published in the March 2009 issue of Archives of Neurology. This special issue, titled, Archives of Neurology: Neurological Disorders Related to Obesity, Diabetes Mellitus, the Metabolic Syndrome, and Other Comorbidities, is part of a special JAMA/Archives focus on diabetes and metabolic disorders.

"These findings indicate that controlling vascular conditions may be one way to delay the course of Alzheimer's, which would be a major development in the treatment of this devastating disease as currently there are few treatments available to slow its progression," said Yaakov Stern, Ph.D., a professor at the Taub Institute for the Research on Alzheimer's Disease and the Aging Brain and director of the Cognitive Neuroscience Division of the Gertrude H. Sergievsky Center at Columbia University Medical Center, and senior author of the paper.

"Preventing heart disease, stroke and diabetes - or making sure these conditions are well managed in patients diagnosed with them - can potentially slow the disease progression of Alzheimer's," said Dr. Stern.

Dr. Stern and the research team used longitudinal data for a mean of 3.5 years (up to 10.2 years) for 156 people diagnosed with Alzheimer's disease who were participants in the Washington Heights/Inwood Columbia Aging Project, a 10-year multi-ethnic, prospective, epidemiological study of cognitive aging and dementia in northern Manhattan.

"Through the Washington Heights/Inwood Columbia Aging Project, we were able to follow patients before they began to show symptoms of Alzheimer's and for several years following their diagnosis. This makes our estimates of progression much more powerful, since we were able to know exactly when cognitive decline began," said Dr. Stern.

They found that a history of diabetes and higher cholesterol levels (total cholesterol and LDL-C) was associated with faster cognitive decline. A history of heart disease and stroke was found to be associated with cognitive decline only in carriers of the apolipoprotein E µ4 (APOE-µ4) gene, which has been implicated in late-onset Alzheimer's disease.

Researchers from Columbia's Taub Institute have previously demonstrated a link between stroke, diabetes, smoking, hypertension and a higher risk of Alzheimer's disease. While vascular risk factors have been studied as predictors of Alzheimer's, few studies have assessed their influence on disease progression. As the authors write, "There has been intense interest in identifying modifiable Alzheimer's disease risk factors such as cardiovascular risk factors, with the goal of preventing or at least delaying disease onset. However, little attention has been given to the influence of these factors on disease progression."

Dr. Stern and the research team theorize that the link between vascular risk factors and faster cognitive decline in patients with Alzheimer's disease may occur because vascular diseases may increase oxidative stress or activate inflammation in the brain, thereby triggering the production of amyloid, and/or triggering the formation of neuron tangles - known as neurofibrillary tangles - which are believed to be a primary cause of Alzheimer's disease.

Dr. Stern and his colleagues are continuing to study the basis of the links between vascular risk factors and Alzheimer's disease using epidemiologic and imaging approaches.

Columbia University Medical Center provides international leadership in basic, pre-clinical and clinical research, in medical and health sciences education, and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions.

Established in 1767, Columbia's College of Physicians and Surgeons was the first institution in the country to grant the M.D. degree and is now among the most selective medical schools in the country. Columbia University Medical Center is home to the most comprehensive medical research enterprise in New York City and state and one of the largest in the United States. Columbia University Medical Center is affiliated with NewYork-Presbyterian Hospital, the nation's largest not-for-profit hospital provider. For more information, please visit www.cumc.columbia.edu.

Media Contact:
Elizabeth Streich
212-305-3900

###

Read the full story at http://www.prweb.com/releases/Diabetes_Cholesterol/Alzheimer/prweb2210014.htm.


'/>"/>
Source: PRWeb
Copyright©2009 Vocus, Inc.
All rights reserved

Related medicine news :

1. New Tel Aviv University research links diabetes to cognitive deterioration
2. Canada to host diabetes mega-congress
3. Stress May Raise Diabetes Risk for Obese Black Women
4. Photos: The American Diabetes Association, Fitness Expert Kathy Smith and Beachbody(R) Join Forces to Combat Type 2 Diabetes
5. Juvenile Diabetes Research Foundation Names Monye Connolly Corporate Chair for its Annual Walk to Cure Diabetes
6. Free Seminars Offered to Georgia Seniors with Diabetes and Other Chronic Illnesses
7. Study shows potential for resolving type 2 diabetes with bariatric surgery
8. Latinos Manage Diabetes With Help From the Community
9. Many faces of diabetes in American youth: The SEARCH for diabetes in youth study
10. Taking Action Together Aims to Increase Screenings and Offer Education to People with Diabetes Living in the Inland Empire
11. Team-based diabetes care fetches more value for dollar
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, the leading ... with Tennessee Counseling Association. This new relationship allows TherapySites to continue ... Association, adding exclusive benefits and promotional offers. , "TCA is extremely excited about ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star ... , Millions of individuals in the United States and Canada wear eyeglasses. Once considered ... both correct vision and make a fashion statement. Even celebrities use glasses as a ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
Breaking Medicine Technology: