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Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease
Date:6/19/2013

roid Autoimmunity: The Role of Endoplasmic Reticulum Stress

Thyroid autoimmunity might be triggered by a process called Endoplasmic Reticulum (ER) stress, which can even occur following a viral infection, according to Angela Lombardi, PhD, a post-doctoral fellow at the Icahn School of Medicine at Mount Sinai. Dr. Lombardi was mentored by Yaron Tomer, MD, FACP, Chief of the Hilda & J. Lester Gabrilove Division of Endocrinology, Diabetes and Bone Disease at The Mount Sinai Medical Center.

ER stress is a process in which cell production and packaging of newly-synthesized proteins is perturbed. This can trigger an autoimmune response which can lead to inflammation and cause cell death. In this study, a human thyroid cell line and human primary thyroid cells were exposed to interferon-alpha (IFN-a), a protein which is secreted during infections. The cells were then tested for markers of ER stress. As a result, both the cell line and the primary thyroid cell cultures showed high levels of ER stress.

“This study showed that one of the main proteins produced by cells in response to infection can also cause ER stress in thyroid cells which can trigger thyroid autoimmunity,” said Dr. Tomer. “This discovery will enable us to test ER stress blockers for their effectiveness to treat and prevent thyroid immunity in the future.”

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About the Division of Endocrinology, Diabetes and Bone Disease at Mount Sinai
The mission of the Division of Endocrinology, Diabetes & Bone Disease is excellence in the delivery of patient care, research, and education. Researchers in the division are expanding understanding of disease and identifying new treatments. The next generation of physicians, scientists and physician-scientists are being trained to take the latest advances in the laboratory and apply them at the bedside. All of the division’s efforts are targeted to bring the highest quality care to patients. For more info
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