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Diabetes Patients That Bring Glucose Meters to Doctor Visits Have Better Control Over Their Disease
Date:6/19/2013

by PCa cells in bone metastases modulates RANKL/OPG expression in both PCa and OB cells and therefore inhibitors of PAP may effectively target the RANKL/OPG system and treat bone metastases.

The study took place from February 2012 until April 2013 and was funded through an Exploration Hypothesis Award from the Department of Defense Prostate Cancer Research Program.

  •      Pathways to Thyroid Stimulation: Identification of New Potent and Selective Small Molecular Agonists to the TSH Receptor

Mount Sinai researchers have identified two novel and potent small molecular compounds proven to be effective in stimulating the thyroid gland and producing more thyroid hormone.

For this study, Terry F. Davies, MD, the Florence and Theodore Baumritter Professor of Medicine at the Icahn School of Medicine at Mount Sinai and his research team screened 50,000 molecules, narrowed them down to 20 molecules which had activity and then identified two molecules with high potency and specificity.

“One of the two molecules identified has a very impressive potency and the potential to be used as a diagnostic tool and therapeutic agent in individuals,” said Dr. Davies. “This newly- identified molecule could lead to the pharmaceutical development of a very effective form of human thyroid-stimulating hormone (TSH), similar to Thyrogen. This drug works by binding to TSH receptors on normal thyroid cells or on thyroid cancer tissue and helps to determine if there are any thyroid cells or thyroid cancer cells remaining after removal of the thyroid gland. Our identification of such novel and potent molecules could have the potential to develop new treatments for thyroid dysfunction, including thyroid cancer, in the future.”

  •     Prevalence of Primary Aldosteronism in an Urban Hypertensive Population

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