Navigation Links
Diabetes Linked to Blood Vessel Inflammation
Date:12/6/2007

Easing the blood sugar disease may help the heart, researchers say

THURSDAY, Dec. 6 (HealthDay News) -- U.S. researchers say they've identified a new pathway that increases a dangerous inflammation of blood vessels in people with diabetes.

A team at the University of California, Davis, Health System believes that good control of diabetes may reduce this inflammation and possibly reduce the risk of cardiovascular disease.

They found that people with type 1 diabetes have increased expression and signaling of two key receptors within the innate immune system. These receptors (TLR2 and TLR4) are part of a family of pattern-recognition receptors called Toll-like receptors (TLRs).

Increased expression of TLR2 and TLR4 in people with type 1 diabetes contributes to inflammation of blood vessels, the study authors said. Their finding is published in the online issue of the Journal of Clinical Endocrinology & Metabolism.

"It is not unreasonable to speculate that TLR2 and TLR4 promote (cardiovascular disease) by contributing to the pro-inflammatory state in type 1 diabetes," lead author Ishwarlal Jialal, director of the Laboratory for Atherosclerosis and Metabolic Research, and professor of internal medicine at UC Davis, said in a prepared statement.

"Inflammation is central to heart disease, playing a pivotal role in plaque formation and stroke. We may well find that a serendipitous byproduct of controlling diabetes is the simultaneous control of this new pathway, leading to less inflammation and lower risk of heart problems," Jialal said.

The researchers plan further studies to investigate the molecular mechanisms that cause increased TLR2 and TLR4 expression and how these receptors contribute to inflammation in people with diabetes.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Disease has more about

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Adverse housing conditions contribute to diabetes risk
2. RAND finds cases of undiagnosed diabetes drop sharply
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Diabetes appears to increase risk of death for patients with acute coronary syndromes
5. Discovery of sugar sensor in intestine could benefit diabetes
6. Despite overeating, morbidly obese mice gain protection against diabetes
7. Heart Attack Boosts Diabetes Risk
8. Obesity Doesnt Always Equal Diabetes
9. Sugary Sodas High in Diabetes-Linked Compound
10. Treating diabetes during pregnancy can break link to childhood obesity
11. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... months the trends for evening dresses shift and ... of the hottest styles in the next few months.” The ... 26 A-line sweetheart evening dresses, and announces the availability of ... trying our best to help a lady to show off ... prices, we provide discounted delivery costs to our customers worldwide. ...
(Date:12/25/2014)... CA (PRWEB) December 25, 2014 The short ... was created in honor of a true 9/11 hero, ... two film festivals including the 24 hours of Nuremberg International ... in Bangladesh. , Actress, screenwriter and director Luciana ... produce this film together with her husband, Gregory Graham ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Helen Harris’ ... in Woodland Hills, California after an 8 year battle ... on Christmas Eve evening in her home in Woodland ... metastatic breast cancer. , As the ... forty years, she pioneered and championed many of today's ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... children with complex chronic illnesses can receive effective, less expensive ... with easy access to a team of dedicated health care ... to become seriously ill and need either hospitalization or a ... an enhanced medical home clinic at the University of Texas ...
(Date:12/25/2014)... early stage breast cancer patients who undergo chemotherapy and/or ... eventually develop leukemia as a result of their treatment, ... a review of more than 20,000 breast cancer cases ... the risk for developing treatment-related leukemia, though low, is ... frequency of bone marrow cancers such as leukemia is ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... ... The Collaboration for a New Century (The Collaboration) announced ... in Arizona. The program called savingsdrugcard.com provides a free drug card ... Interested individuals simply download this card by visiting http://www.SavingsDrugCard.com ...
... quell the urge, researchers say , TUESDAY, July 7 ... ease the urges of people with a compulsive hair-pulling ... the effectiveness of the amino acid N-acetylcysteine in a ... age of 34. Most had started compulsive hair pulling ...
... PCYC ) announced today that it has set ... record date for its upcoming Rights Offering. To participate in ... purchased on or before July 10, 2009, assuming a three ... be made through the distribution of non-transferable subscription rights to ...
... Structural cardiovascular abnormalities present at birth are the ... a million children in the United States have structural ... such as small holes between chambers of the heart, ... or more chambers or valves. The July issue ...
... ... manufacturer of the permanent makeup worn by the late Michael Jackson, are speaking out against ... ... Hammons , celebrity permanent makeup artist and her company, Premier Pigments , the manufacturer ...
... IBM ) was awarded the prestigious Coffey International ... address the greatest societal challenges of our time at the annual ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20090416/IBMLOGO ) ... Community Grid , in essence the virtual equivalent in processing ...
Cached Medicine News:Health News:Popular Prescription Drug Discount Card Now Available in Arizona Online 2Health News:Popular Prescription Drug Discount Card Now Available in Arizona Online 3Health News:Supplement Might Help Compulsive Hair Pullers 2Health News:Pharmacyclics Sets Record Date for Rights Offering 2Health News:Pharmacyclics Sets Record Date for Rights Offering 3Health News:New strategies to improve treatment and ultimately prevent heart failure in children 2Health News:New strategies to improve treatment and ultimately prevent heart failure in children 3Health News:Celebrity Permanent Makeup Artist Slams Claim "Michael Jackson Didn't Want to be Black" 2Health News:Celebrity Permanent Makeup Artist Slams Claim "Michael Jackson Didn't Want to be Black" 3Health News:IBM Award for Innovative Solution to Tackling World's Most Critical Social and Environmental Problems 2Health News:IBM Award for Innovative Solution to Tackling World's Most Critical Social and Environmental Problems 3Health News:IBM Award for Innovative Solution to Tackling World's Most Critical Social and Environmental Problems 4Health News:IBM Award for Innovative Solution to Tackling World's Most Critical Social and Environmental Problems 5
(Date:12/24/2014)... 2014 Kinex Pharmaceuticals announced today that the ... Park Cancer Institute. KX2-361 (KX02), a dual ... shown potent inhibitory activity against a broad panel of ... to Temozolomide (T98G), the most widely used chemotherapy for ... tumor mouse model, KX2-361 consistently clears brain tumors after ...
(Date:12/24/2014)... -- The International Trade Commission (ITC) issued its final decision in ... a notice issued on December 23, the ITC ruled in ... humidifier was invalid. BMC President, James Xu ... excited with the ITC,s decision in this case. This victory ... the very beginning on the key patents in the case. ...
(Date:12/24/2014)... Mich. , Dec. 24, 2014  Diplomat Pharmacy, ... independent specialty pharmacy, is proud to announce Jennifer ... quality at Diplomat, will take office as the president ... The formal induction ceremony will take place Feb. 28, ... will be held at the Renaissance Center in ...
Breaking Medicine Technology:Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: