Navigation Links
Diabetes Linked to Blood Vessel Inflammation
Date:12/6/2007

Easing the blood sugar disease may help the heart, researchers say

THURSDAY, Dec. 6 (HealthDay News) -- U.S. researchers say they've identified a new pathway that increases a dangerous inflammation of blood vessels in people with diabetes.

A team at the University of California, Davis, Health System believes that good control of diabetes may reduce this inflammation and possibly reduce the risk of cardiovascular disease.

They found that people with type 1 diabetes have increased expression and signaling of two key receptors within the innate immune system. These receptors (TLR2 and TLR4) are part of a family of pattern-recognition receptors called Toll-like receptors (TLRs).

Increased expression of TLR2 and TLR4 in people with type 1 diabetes contributes to inflammation of blood vessels, the study authors said. Their finding is published in the online issue of the Journal of Clinical Endocrinology & Metabolism.

"It is not unreasonable to speculate that TLR2 and TLR4 promote (cardiovascular disease) by contributing to the pro-inflammatory state in type 1 diabetes," lead author Ishwarlal Jialal, director of the Laboratory for Atherosclerosis and Metabolic Research, and professor of internal medicine at UC Davis, said in a prepared statement.

"Inflammation is central to heart disease, playing a pivotal role in plaque formation and stroke. We may well find that a serendipitous byproduct of controlling diabetes is the simultaneous control of this new pathway, leading to less inflammation and lower risk of heart problems," Jialal said.

The researchers plan further studies to investigate the molecular mechanisms that cause increased TLR2 and TLR4 expression and how these receptors contribute to inflammation in people with diabetes.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Disease has more about diabetes, heart disease and stroke.



-- Robert Preidt



SOURCE: University of California, Davis, news release, Nov. 27, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Adverse housing conditions contribute to diabetes risk
2. RAND finds cases of undiagnosed diabetes drop sharply
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Diabetes appears to increase risk of death for patients with acute coronary syndromes
5. Discovery of sugar sensor in intestine could benefit diabetes
6. Despite overeating, morbidly obese mice gain protection against diabetes
7. Heart Attack Boosts Diabetes Risk
8. Obesity Doesnt Always Equal Diabetes
9. Sugary Sodas High in Diabetes-Linked Compound
10. Treating diabetes during pregnancy can break link to childhood obesity
11. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... Splashtop Inc., the worldwide leader in ... Networks Co., the leading provider of secure mobile remote access solution for Japan ... leading CACHATTO remote access solution. Splashtop for CACHATTO will be available as ...
(Date:5/31/2016)... ... May 31, 2016 , ... The ... advanced Artificial Intelligence (AI) and the latest in Clinical Patient Pod ... integrating predictive analytic outputs directly into the clinical workflow. These insights are empowering ...
(Date:5/31/2016)... Maryland (PRWEB) , ... May 31, 2016 , ... ... to attribute calls back to particular advertising campaigns, to monitor the performance of ... that they can maximize conversions and revenue. The software allows customers to record, ...
(Date:5/31/2016)... ... 31, 2016 , ... The successful implementation of “lean manufacturing” in various fields ... laboratories have different challenges compared to manufacturing environments. , In order to provide ... TOLEDO has developed the Lean Lab Checklist . This checklist will help users ...
(Date:5/31/2016)... San Francisco, CA (PRWEB) , ... May 31, 2016 , ... ... and cases for digital-minded professionals, announces the waxed-canvas and leather Duo Dopp Kit ... lightweight, durable waxed canvas or ballistic nylon, the Duo is smartly designed ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... -- On 28 May, 194 Member States made ... the 69 th World Health Assembly, governments unanimously voted ... the greatest global commitment in viral hepatitis to date. ... and C by 2030 and includes a set of prevention ... by 65% and increase treatment to 80%, saving 7.1 million ...
(Date:5/30/2016)... 2016 LifeScienceIndustryResearch.com adds "Ulcerative ... report with comprehensive information on the therapeutic development ... various stages, therapeutics assessment by drug target, mechanism ... molecule type, along with latest updates, and featured ... players involved in the therapeutic development for Ulcerative ...
(Date:5/27/2016)... -- A new study highlights the necessity of health literacy within the technology advancement of ... of Radiology , a majority of oncology patients undergo imaging screenings without understanding the ... ... ... Medical Diagnostic Imaging Ampronix ...
Breaking Medicine Technology: