Navigation Links
Diabetes Insight Could Lead to Better Treatments
Date:12/21/2009

as a response to high blood sugar. These islet cells are also responsible for secretion of insulin.

To determine if islet production of IL-1b was caused by the interaction of NLRP3 and TXNIP, the researchers exposed islet cells from normal mice and from mice deficient in NLRP3 or TXNIP to high glucose levels. As predicted, the protein-deficient islets made less IL-1b.

What's more, these deficient mice cleared glucose from the bloodstream quicker in response to insulin.

"Our findings predict that type 2 diabetes can be treated by inhibitors of the inflammasome or IL-1b," Tschopp said.

The good news is that these effects of NLRP3 are confined to the insulin-producing beta cells of the pancreas, so compounds to inhibit the pathway should not have systemic effects.

Studies in humans are already under way. According to Tschopp, "clinical studies with type 2 diabetes patients have already been initiated and the first results are again incredibly encouraging. With a single injection of IL-1b inhibitors, glucose levels in diabetes patients are highly reduced during six months. This treatment could replace the standard treatment currently used."'

More information

There's more on type 1 and type 2 diabetes at the American Diabetes Association.



SOURCES: Jurg Tschopp, Ph.D., professor, University of Lausanne, Epalinges, Switzerland; Norma Kenyon, M.D., Martin Kleiman professor of surgery, medicine, microbiology and immunology and biomedical engineering, Diabetes Research Institute, University of Miami Miller School of Medicine; Dec. 21, 2009, online Nature Immunology


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Orameds Dr Roy Eldor was Chosen to Lecture at the First International Conference Held by the Bildirici Center for Diabetes Care Research in Israel.
2. UCSF/SFGH project for diabetes patients wins award for innovation, quality
3. SFGH Project for Diabetes Patients Wins Award for Innovation, Quality
4. Sermo Vitals Report(TM) Quantifies One Year of Physician Conversation About Diabetes
5. TrekDesk: A Potentially Positive Impact on Diabetes & Obesity
6. Coffee, Tea Might Stave Off Diabetes
7. UNC scientists coordinate study of link between insulin use and cancer in people with diabetes
8. Study finds over 90 percent of people with gum disease are at risk for diabetes
9. Study shows how gene action may lead to diabetes prevention, cure
10. Bears Quarterback Jay Cutler and Eli Lilly and Company Will Send 44 Kids to American Diabetes Association Camps Through the Touchdowns for Diabetes Campaign
11. Chinese-American and Korean-American women at highest risk for diabetes in pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Liberty University has received accreditation for its resident Clinical ... for Accreditation of Counseling & Related Educational Programs (CACREP). ... & Family Studies , is under the leadership of Dr. ... Behavioral Sciences. Prior to the formation of the new school, ...
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, ... Health Alliance (PPHA). The PPHA's passion for others' well-being ... NFL greats, treated for obstructive sleep apnea (OSA) has propelled ... cause in the valley. The most recent plans for an ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 AngelWeddingDress, the ... of 2015 maternity wedding dresses. View website ... are looking for maternity wedding dresses online for a ... gowns with high quality for them. Its maternity wedding ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining ... policy . , Auto insurance quotes help many drivers ... longer necessary to call an agent or visit an agency ... a single website: http://autocarinsurancebest.com/ . , Every business who ...
(Date:1/22/2015)... Calif. (PRWEB) January 22, 2015 ... Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were ... their leadership in advancing biotechnology, biomedical science, medical ... and Olsen each received the “2014 Life Sciences ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
... Sept. 27 (HealthDay News) -- Rude employee behavior is ... businesses, a new U.S. study finds. Researchers surveyed ... experienced or witnessed insensitive, disrespectful or rude employee behavior ... this incivility makes them less likely to return to ...
... rates linked to climate change will increase in several European ... study, which will be presented today (27 September 2011) at ... Belgium, France, Spain and Portugal will see the biggest climate-induced ... The research is part of the Climate-TRAP project and ...
... Netherlands: The negative effects that premature birth can have on ... premature babies as those born extremely prematurely but may be ... The research will be presented at the European Respiratory ... Normal pregnancy lasts 40 weeks, which allows enough time for ...
... By Amanda Gardner HealthDay Reporter , MONDAY, ... cautionary note Monday about an increased risk of blood clots ... as Yaz or Yasmin. Although stopping short of a ... say it "remains concerned" about a potentially higher risk of ...
... It,s an ongoing debate: Should men over a certain age ... to treatments that may result in significant side effects if ... study by researchers at UCLA,s Jonsson Comprehensive Cancer Center has ... undertreated, while patients with a single comorbid condition such as ...
... Sept. 26 (HealthDay News) -- People with heart disease who ... to a normal rate after exercise, a new study suggests. ... normal heart rate recovery live longer than those whose hearts ... "There,s no medicine that can do that," study author Dr. ...
Cached Medicine News:Health News:Climate change set to increase ozone-related deaths over next 60 years 2Health News:Lung function of moderately premature babies is reduced at 8-9 years but may improve with age 2Health News:Newer Contraceptive Pills Could Raise Clot Risk, FDA Warns 2Health News:Elderly patients may be undertreated for prostate cancer 2Health News:Elderly patients may be undertreated for prostate cancer 3Health News:Cardiac Rehab May Help Heart Patients Live Longer 2
(Date:1/23/2015)... Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ... and sale of patented biopharmaceutical medicine, modernized traditional Chinese ... today announced the business and development progress at its ... Following the September 2014 JCM application (No. 51268) for ...
(Date:1/22/2015)... Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), a specialty ... disease and overall health is pleased to provide you with ... outlook for 2015 from the CEO, Mr. Eugene Bortoluzzi ... like to take this opportunity to share with you the ...
(Date:1/22/2015)... and Markets ( http://www.researchandmarkets.com/research/3h534b/infectious ) has announced ... by Product, Application, Technology, End User - Global Forecast ... The infectious disease diagnostics market is expected to ... by 2019 from $12,422.8 million in 2014. Increase in ...
Breaking Medicine Technology:TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 2Global Infectious Disease Diagnostics (Instruments, Reagents, Services, Software) Market - Forecast to 2019 3
... , GREENWOOD VILLAGE, Colo. , June 28 ... cycle solutions for the healthcare industry, announced today the ... to integrate various and disparate hospital systems, applications, software ... were designed and developed decades ago, hospitals have been ...
... that a new market research report is available in its catalogue: , ... Global Acute Coronary Syndrome industry , ... http://www.reportlinker.com/p0197235/Global-Acute-Coronary-Syndrome-industry.html , , , ... for Acute Coronary Syndrome Therapeutics in US$ Million. Annual estimates and forecasts are provided for ...
Cached Medicine Technology:Recondo Technology Announces Integration Initiative for US Hospital Systems 2Recondo Technology Announces Integration Initiative for US Hospital Systems 3Recondo Technology Announces Integration Initiative for US Hospital Systems 4Global Acute Coronary Syndrome Industry 2Global Acute Coronary Syndrome Industry 3Global Acute Coronary Syndrome Industry 4Global Acute Coronary Syndrome Industry 5Global Acute Coronary Syndrome Industry 6Global Acute Coronary Syndrome Industry 7Global Acute Coronary Syndrome Industry 8Global Acute Coronary Syndrome Industry 9Global Acute Coronary Syndrome Industry 10Global Acute Coronary Syndrome Industry 11Global Acute Coronary Syndrome Industry 12Global Acute Coronary Syndrome Industry 13Global Acute Coronary Syndrome Industry 14Global Acute Coronary Syndrome Industry 15Global Acute Coronary Syndrome Industry 16Global Acute Coronary Syndrome Industry 17Global Acute Coronary Syndrome Industry 18
... Properly identifying patients and visitors is ... efficient hospital environment. Achieve this and ... a highly-scalable patient and visitor identification ... size. IdentifiOR can be used stand-alone, ...
... follows function in this simple-to-operate Z4Mplus™ ... both 203 dpi (8 dots/mm) and ... performer offers many standard features, including ... centralized printer management. Rely on these ...
... The R4Mplus offers global companies ... help meet RFID compliance initiatives. With ... a variety of connectivity options, and ... is a super value. Plus, the ...
... The industrys first 600 dpi printer ... large amounts of bar code, text ... space. This printer is ideal for ... electronic components, telecommunication assemblies, computer peripherals, ...
Medicine Products: