Navigation Links
Diabetes Drug Metformin Linked to Lower Lung Cancer Rate in Mice
Date:9/1/2010

By Amanda Gardner
HealthDay Reporter

WEDNESDAY, Sept. 1 (HealthDay News) -- A drug widely used to treat high blood sugar in type 2 diabetics may hold some promise in the prevention of tobacco-induced lung cancer, according to extremely preliminary findings in a mouse study.

In the September issue of Cancer Prevention Research, researchers report that metformin was associated with a substantial reduction (up to 73 percent) in the number of tumors mice developed when they were given a common carcinogen found in tobacco.

Despite the fact that there have been no randomized controlled trials on whether metformin really can prevent cancer, researchers expressed excitement both over this animal study and previous epidemiological evidence pointing to this possibility.

Metformin (originally marketed as Glucophage, though it is now available as an inexpensive generic) has been in use for more than two decades and is currently prescribed to 40 million Americans.

"This is a very safe agent and has been around for a while," said Cancer Prevention Research editor-in-chief Dr. Scott Lippman, chair of thoracic head and neck medical oncology at the University of Texas M.D. Anderson Cancer Center in Houston, at a Wednesday news conference.

"The evidence in diabetic humans is very convincing and very strong," added Dr. Phillip Dennis, a senior investigator with the U.S. National Cancer Institute and senior author on the lung cancer paper. "Almost every epidemiological study I can think of found a decreased cancer incidence in diabetics taking metformin. The reduction is real and ranges from 30 to 70 percent."

The researchers thought metformin's possible cancer-lowering properties suggested the need for clinical trials to investigate whether the drug might help prevent tumors in smokers at high risk of developing cancer. Others believed that the finding might influence the choice of drugs in people with diabetes.

"All other things being equal, many diabetics face a choice of oral agents, and early evidence that metformin may have an effect on the oncology side may increasingly play a role in decision-making," said Dr. Michael Pollack, professor of medicine and oncology at McGill University in Montreal. "We can't ignore this, but we can't say we have FDA [U.S. Food and Drug Administration] approval for metformin for cancer indications."

Metformin was developed from the French lilac plant, known in the Middle Ages to control excess urination, a symptom of uncontrolled diabetes. The drug was approved by the FDA in the mid-1990s.

The study by Dennis and colleagues looked at mice that had been genetically engineered to be susceptible to lung tumors.

Mice taking metformin in their drinking water had 34 percent fewer tumors than those not taking metformin. And when the drug was administered by injection, the improvement seen was 73 percent.

Dennis stated that a likely mechanism of action resides in the liver "and specifically the hormones [including insulin] that are released." Insulin may have a relationship with cancer.

"It's most likely that metformin is working by reducing insulin and IGF1 [insulin-like growth factor] levels in the body," said Lewis Cantley, director of the Cancer Center at Beth Israel Deaconess Medical Center in Boston, and co-author of an accompanying perspective piece.

It's also possible, however, that metformin is working more directly on the tumor process, the researchers said.

A second study, this one a randomized controlled trial involving a very small number of humans (23), found that patients with an early form of colorectal cancer who were treated with metformin did see a decrease in possible cancer-related growth, compared with participants not taking the drug.

"These patients were not diabetic, so they didn't necessarily have high insulin levels to begin with but lower insulin levels," Cantley explained.

This adds credence to the idea that metformin's value is in its ability to lower overall insulin levels in the body, Cantley said.

At this point, no one knows if metformin is safe in non-diabetic populations but some clinical trials are starting to look at the issue, Lippman said.

And, pointed out Dr. Lucas Wong, associate professor of internal medicine at Texas A&M Health Science Center College of Medicine and co-director of the Gastrointestinal Cancer Program at Scott & White in Temple, Texas, while the new research is "interesting and thought-provoking, what's proven in humans is totally another level."

More information

The U.S. National Library of Medicine has more on metformin.

SOURCES: Lucas Wong, M.D., associate professor of internal medicine, Texas A&M Health Science Center College of Medicine and co-director, Gastrointestinal Cancer Program, Scott & White, Temple, Texas; Sept. 1, 2010 teleconference with Scott Lippman, M.D., editor-in-chief, Cancer Prevention Research and professor and chair, department of thoracic head and neck medical oncology, University of Texas M.D. Anderson Cancer Center; Michael Pollack, M.D., professor of medicine and oncology, McGill University, Montreal; Phillip Dennis, M.D., Ph.D., senior investigator, U.S. National Cancer Institute; Lewis Cantley, Ph.D., director, Cancer Center, Beth Israel Deaconess Medical Center, Boston; September 2010, Cancer Prevention Research


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Neighborhood socioeconomic status and diabetes
2. NACDD Receives Two-Year Grant From Merck & Co., Inc. to Improve Diabetes Education
3. International Diabetes Federation awards $2 million to 9 global diabetes research projects
4. Diabetes drug ups risk for bone fractures in older women
5. Diabetes Drugs Avandia, Actos Tied to Fractures in Women
6. Fishy Smell May Keep Patients From Diabetes Drug
7. Small Increase in Diabetes Risk Noted in Statin Patients
8. FDA Approved Diabetes Drug Despite Hints at Cancer Risk
9. Remove Diabetes Drug Avandia From Market: FDA Reports
10. Remove Diabetes Drug Avandia From Market: FDA Documents
11. Excessive Weight Gain During Pregnancy Raises Gestational Diabetes Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diabetes Drug Metformin Linked to Lower Lung Cancer Rate in Mice
(Date:2/24/2017)... ... February 24, 2017 , ... With millions of Americans ... important that we all are aware of our options and are empowered with ... announce the launch of its newest edition of "Vision and Hearing" in USA ...
(Date:2/24/2017)... CA (PRWEB) , ... February 24, 2017 , ... The ... 2017 national conference convening academic faculty engaged in or interested in palliative care education ... Research,” will be held in North County San Diego on Sept. 28 and ...
(Date:2/24/2017)... ... February 24, 2017 , ... The Radiology Business ... in radiology marketing programs at the annual Building Better Radiology Marketing Programs ... Worth Hotel in Fort Worth, Texas. Nine awards are given out in five categories. ...
(Date:2/23/2017)... ... 2017 , ... Thinksport, the most award-winning sunscreen on the ... Marin. For the second year in a row, cyclists will stay protected from ... thrilled to provide our safe, non-toxic sunscreen to over 2,000 cycling enthusiasts again ...
(Date:2/23/2017)... ... 23, 2017 , ... Rare Disease Report®, which is the ... Rare Disease Day events, hosted by the Rare Disease Legislative Advocates (RDLA) on ... weekly e-newsletter and quarterly publication, will be conducting interviews with patients and advocates ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... BRISBANE, Australia , Feb. 23, 2017  Directors from Pharma ... the two companies have joined forces, resulting in the founding of ... . Pharma To Market are pleased to announce their ... an office in Singapore . The company are ... Consulting as Co-Director of the Singapore based ...
(Date:2/24/2017)... , Feb. 23, 2017 ... insights on the various drugs being developed ... covers all the drugs that are in ... Clinical). The pipeline focuses on novel pharmacologic ... antibodies, stem cell therapies, recombinant proteins and ...
(Date:2/24/2017)... Feb 24, 2017 Medivir AB ... for a new Board of Directors that will be ... Nomination Committee comprises representatives of the company,s three largest ... 2016 who have accepted a seat on the Nomination ... of the 2016-2017 Nomination Committee was as follows:  ...
Breaking Medicine Technology: