Navigation Links
Diabetes Drug May Cut Med-Related Weight Gain
Date:1/8/2008

Metformin plus lifestyle intervention counteracts pounds added by antipsychotics

TUESDAY, Jan. 8 (HealthDay News) -- Improved diet, more exercise and the diabetes medication metformin can help people suffering with schizophrenia control the weight gain that typically accompanies their medications, a Chinese study suggests.

Three months of both medication and lifestyle change resulted in a loss of two centimeters around the waist as well as improvement in other health measures, such as insulin resistance, the researchers report in the Jan. 9/16 issue of the Journal of the American Medical Association.

Metformin is typically prescribed to help control blood sugar levels in people with diabetes. Previous research has shown that metformin can prevent weight gain in people with diabetes and may help manage weight in some overweight people.

Doctors prescribe atypical antipsychotic (AAP) medications to manage a variety of psychotic disorder and behavioral disturbances, including schizophrenia. However, the drugs often also affect the body's metabolism, resulting in unhealthy cholesterol levels, weight gain and glucose intolerance.

A team based at the Mental Health Institute of the Second Xiangva Hospital, Central South University, China, tested the effect of metformin and lifestyle changes, together and separately, on the weight and insulin levels of 128 adults with schizophrenia. All the participants had gained at least 10 percent of their body weight after starting antipsychotic medications.

The participants were randomly assigned to one of four groups for 12 weeks, while continuing their medication: One group received a placebo or sugar pill; the second one received 750 milligrams per day of metformin; the third received 750 milligrams per day of metformin with lifestyle intervention; and the fourth went through the lifestyle intervention alone. The lifestyle interventions included health education, diet and exercise.

An analysis of the data found that patients in the combination group and patients who took either metformin or engaged in lifestyle change all reduced their weight, body-mass index (a measure of height and weight), waist circumference, insulin levels and insulin resistance.

The participants who took metformin and changed their diet and exercise saw a decrease of 1.8 in their body-mass index, 3.6 in insulin resistance and lost two centimeters in waist circumference. Metformin alone resulted in an average loss of 1.2 in body-mass index, 3.5 in insulin resistance and 1.3 centimeters from the waist. Those who only exercised and changed their diet saw a loss of 0.5 in body-mass index and 1.0 in insulin resistance, but they were no slimmer at the waist. People who took the placebo continued to increase in body mass, waist and insulin resistance, said the researchers.

More information

To learn more about how to increase physical activity, visit the U.S. Department of Agriculture.



-- Madeline Vann



SOURCE: Journal of the American Medical Association, news release, Jan. 8, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Carrot cake study on sugar in type 2 diabetes
2. Lack of Deep Sleep Raises Diabetes Risk
3. Lack of deep sleep may increase risk of type 2 diabetes
4. Childhood Diabetes Boosts Risk for Kidney Problems
5. Diabetes Group Backs Low-Carb Diets
6. GDAHC Save Lives Save Dollars Initiative Launches Pilot Program for Diabetes Care Management
7. Treating Depression Cuts Diabetes Death Risk
8. The Diabetes Educator publishes systematic reviews for diabetes management
9. Dallas-Fort Worth Business Group on Health Releases Report on the State of Diabetes in Texas
10. MCG selected as RNA laboratory for worldwide diabetes study
11. More evidence suggests diabetes drug may be dangerous
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diabetes Drug May Cut Med-Related Weight Gain
(Date:3/30/2017)... ... March 30, 2017 , ... ... Academy of Nutrition and Dietetics (AND), will join nonprofit Seafood Nutrition Partnership (SNP) ... a live webinar designed to help nutrition educators and students inform consumers about ...
(Date:3/29/2017)... ... ... ARI Network Services, Inc. (NASDAQ: ARIS) announced today that Rhino Ag has ... of more than 650 U.S.-based dealers. Rhino, a member of the Alamo Group, offers ... and cutters, rear blades, post hole diggers, pasture renovators, tillers, disc mowers and box ...
(Date:3/29/2017)... ... ... is the main cause of hay fever in the United States, with an estimated 95 ... May to July each year; with the worst time for sufferers being June and July. ... http://www.haymax.us ) provide an effective defense against grass pollen; they are proven in independent studies ...
(Date:3/29/2017)... ... 30, 2017 , ... Sports Brand EXOUS Bodygear announced today a special sale ... for the remaining days of March, the price will be only $19.97. The EXOUS ... of just $10 (regular retail price $19.97). , The special promotional prices are to ...
(Date:3/29/2017)... ... 29, 2017 , ... Based on research from Guardian’s Fourth ... in trying to balance both short-term and long-term benefits demands. Are employers ... growing complexity, companies are finding that the short-term strategies used to control costs, ...
Breaking Medicine News(10 mins):
(Date:3/30/2017)... 30, 2017 Revenue Prospects by Product Type ... COPD) and Geography Respiratory Inhalers - our new study ... Respiratory Inhalers market heading? If you are involved in this sector ... shows you the potential revenues streams to 2027, assessing data, trends, ... ...
(Date:3/29/2017)... , March 29, 2017 Wound care devices ... healing of the wound. The industry mainly consists of ... for the treatment of wounds caused by mechanical, chemical, ... to diseases such as diabetes, skin related diseases, immunological ... Europe was the largest region in the ...
(Date:3/29/2017)... , March 29, 2017  BioSpecifics Technologies Corp. ... continues to develop collagenase based-therapies with a first ... marketed as XIAFLEX ®  in the U.S. and ... present a corporate overview at the upcoming 16 ... April 5, 2017 at 8:00 a.m. ET in ...
Breaking Medicine Technology: