Navigation Links
Diabetes Drug May Cut Med-Related Weight Gain
Date:1/8/2008

Metformin plus lifestyle intervention counteracts pounds added by antipsychotics

TUESDAY, Jan. 8 (HealthDay News) -- Improved diet, more exercise and the diabetes medication metformin can help people suffering with schizophrenia control the weight gain that typically accompanies their medications, a Chinese study suggests.

Three months of both medication and lifestyle change resulted in a loss of two centimeters around the waist as well as improvement in other health measures, such as insulin resistance, the researchers report in the Jan. 9/16 issue of the Journal of the American Medical Association.

Metformin is typically prescribed to help control blood sugar levels in people with diabetes. Previous research has shown that metformin can prevent weight gain in people with diabetes and may help manage weight in some overweight people.

Doctors prescribe atypical antipsychotic (AAP) medications to manage a variety of psychotic disorder and behavioral disturbances, including schizophrenia. However, the drugs often also affect the body's metabolism, resulting in unhealthy cholesterol levels, weight gain and glucose intolerance.

A team based at the Mental Health Institute of the Second Xiangva Hospital, Central South University, China, tested the effect of metformin and lifestyle changes, together and separately, on the weight and insulin levels of 128 adults with schizophrenia. All the participants had gained at least 10 percent of their body weight after starting antipsychotic medications.

The participants were randomly assigned to one of four groups for 12 weeks, while continuing their medication: One group received a placebo or sugar pill; the second one received 750 milligrams per day of metformin; the third received 750 milligrams per day of metformin with lifestyle intervention; and the fourth went through the lifestyle intervention alone. The lifestyle interventions included health education, diet and exercise.

An analysis of the data found that patients in the combination group and patients who took either metformin or engaged in lifestyle change all reduced their weight, body-mass index (a measure of height and weight), waist circumference, insulin levels and insulin resistance.

The participants who took metformin and changed their diet and exercise saw a decrease of 1.8 in their body-mass index, 3.6 in insulin resistance and lost two centimeters in waist circumference. Metformin alone resulted in an average loss of 1.2 in body-mass index, 3.5 in insulin resistance and 1.3 centimeters from the waist. Those who only exercised and changed their diet saw a loss of 0.5 in body-mass index and 1.0 in insulin resistance, but they were no slimmer at the waist. People who took the placebo continued to increase in body mass, waist and insulin resistance, said the researchers.

More information

To learn more about how to increase physical activity, visit the U.S. Department of Agriculture.



-- Madeline Vann



SOURCE: Journal of the American Medical Association, news release, Jan. 8, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Carrot cake study on sugar in type 2 diabetes
2. Lack of Deep Sleep Raises Diabetes Risk
3. Lack of deep sleep may increase risk of type 2 diabetes
4. Childhood Diabetes Boosts Risk for Kidney Problems
5. Diabetes Group Backs Low-Carb Diets
6. GDAHC Save Lives Save Dollars Initiative Launches Pilot Program for Diabetes Care Management
7. Treating Depression Cuts Diabetes Death Risk
8. The Diabetes Educator publishes systematic reviews for diabetes management
9. Dallas-Fort Worth Business Group on Health Releases Report on the State of Diabetes in Texas
10. MCG selected as RNA laboratory for worldwide diabetes study
11. More evidence suggests diabetes drug may be dangerous
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diabetes Drug May Cut Med-Related Weight Gain
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... ... 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join ... wage raise to $12 an hour by 2020 and then adjusting it yearly to increase ... of the minimum wage, assure the wage floor does not erode again, and make future ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016 Jazz Pharmaceuticals ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... p.m. (Eastern Daylight Time). As previously announced ... into a definitive merger agreement under which Jazz Pharmaceuticals ...
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
Breaking Medicine Technology: