Navigation Links
Diabetes Drug May Boost Weight Loss in Obese Patients
Date:10/23/2009

Combo of diet, exercise and injections helped non-diabetics shed pounds, study finds

FRIDAY, Oct. 23 (HealthDay News) -- The diabetes drug liraglutide helps obese people without diabetes lose weight, researchers have found.

The study authors also reported that high doses of liraglutide were more effective at helping people shed pounds than the weight-loss drug orlistat.

In the study, which included 564 diabetes-free obese patients aged 18 to 65 at 19 sites in Europe, participants were randomly selected to receive one of four injected doses of liraglutide (1.2 milligrams, 1.8 milligrams, 2.4 milligrams or 3 milligrams) or a placebo once a day, or 120 milligrams of orlistat three times a day.

All of the patients also increased their levels of physical activity and followed a calorie-restricted diet, which allowed for about 500 calories less per day than they needed.

Weight loss among patients taking liraglutide doses of 1.2, 1.8, 2.4 and 3 milligrams was 4.8 kilograms (10.5 pounds); 5.5 kilograms (12 pounds); 6.3 kilograms (14 pounds), and 7.2 kilograms (15.8 pounds), respectively, compared with 4.1 kilograms (9 pounds) with orlistat and 2.8 kilograms (6 pounds)with placebo. Weight loss of more than 5 percent occurred in 76 percent of patients taking 3 milligrams of liraglutide, 44 percent of patients taking orlistat, and 30 percent of patients in the placebo group, the researchers found.

Reduced blood pressure was noted in all of the patients taking liraglutide. The groups taking 1.8 to 3 milligrams of liraglutide had an 84 percent to 96 percent reduction in the prevalence of prediabetes, which is poor blood glucose control that's not yet bad enough to qualify as diabetes.

Nausea and vomiting was more common among patients taking liraglutide than among those in the placebo group, the study authors noted.

"The results of this study indicate the potential benefit of liraglutide, in conjunction with an energy-deficit diet, in the treatment of obesity and associated risk factors," wrote Dr. Arne Astrup, of the department of human nutrition at the University of Copenhagen, Denmark, and colleagues.

Additional studies with a follow-up longer than 20 weeks are now needed to investigate the long-term risk/benefit profile of liraglutide, the study authors noted.

The study was released online Oct. 22 in advance of publication in an upcoming print issue of The Lancet.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases outlines the health risks of being overweight.



-- Robert Preidt



SOURCE: The Lancet, news release, Oct. 22, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Adverse housing conditions contribute to diabetes risk
2. RAND finds cases of undiagnosed diabetes drop sharply
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Diabetes appears to increase risk of death for patients with acute coronary syndromes
5. Discovery of sugar sensor in intestine could benefit diabetes
6. Despite overeating, morbidly obese mice gain protection against diabetes
7. Heart Attack Boosts Diabetes Risk
8. Obesity Doesnt Always Equal Diabetes
9. Sugary Sodas High in Diabetes-Linked Compound
10. Treating diabetes during pregnancy can break link to childhood obesity
11. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... Jusino Insurance Services, a locally ... the greater Chicago metropolitan area, is embarking on a charity drive in conjunction ... , Founded in 1897, Hephzibah Children’s Association is one of the oldest social ...
(Date:6/22/2017)... ... June 22, 2017 , ... Plastic Surgery Associates is ... Top Doctor for 2017. Each year, research and information firm, Castle Connolly, releases their ... title in 2015, this marks the 3rd time that Dr. Canales has ...
(Date:6/22/2017)... ... June 22, 2017 , ... The VA Maryland ... Recycling Network has awarded the Baltimore VA Medical Center, a division of the ... for its efforts to promote waste reduction and promote recycling. Also, Practice ...
(Date:6/20/2017)... ... 2017 , ... Connance, a leading provider of healthcare predictive ... analytics drive reimbursement optimization, with a focus on denial management and claims statusing, ... traditional approach to denied and underpaid claims leaves money on the table and ...
(Date:6/20/2017)... ... June 20, 2017 , ... Fresenius Vascular Care, a national ... techniques to treat and manage a wide range of vascular conditions, has today announced ... more than 65 centers represented by more than 40 local brands, a phased rollout ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... , June 6, 2017  Diplomat Specialty Infusion Group, a brand ... environment to its Iowa location. ... now features an ISO 7 cleanroom—the standard needed to ... with a low level of pollutants. ... nutrition consumers and better serve our Iowa ...
(Date:6/1/2017)... 2017 Nutriceutical Holdings (NH), parent company of ... and KD Pharma Group have decided to join forces ... Pharma Group. KD Pharma Group will become the largest ... the entire company. "We believe we have ... to growing the NH companies by providing us with ...
(Date:5/26/2017)... International plc (NASDAQ: ENDP ) announced today that ... Company in a fireside chat at Goldman Sachs, 38 th ... at 10:40 a.m. PT / 1:40 p.m. ET. The conference ... Palos Verdes, CA. A live webcast ... the Company,s website at http://www.endo.com/investors/overview . Participants should allow ...
Breaking Medicine Technology: