Navigation Links
Diabetes Drug Avandia Boosts Heart Risks: Study
Date:9/11/2007

Another study finds a similar drug, Actos, may be a better choice, researchers say

TUESDAY, Sept. 11 (HealthDay News) -- A controversial drug called Avandia, used by millions of diabetics to control blood sugar, greatly increases their risk of heart attack and heart failure, researchers report.

The drug does not up users' overall risk of death, however, the new study finds.

"The balance of risks and benefits has shifted, and this needs to be factored into the equation," said Dr. Sonal Singh, lead author of the study and assistant professor of internal medicine at Wake Forest University School of Medicine in Winston-Salem, N.C.

"The risk of heart failure was known but not the magnitude. A doubling of risk is substantial," Singh added. "One in 30 patients taking rosiglitazone (Avandia) over a year will have heart failure, that's very substantial. And one in 220 will have a heart attack. That's also very substantial." Patients should talk to their doctors about the potential risks and benefits of the drug, Singh said.

The study is published in the Sept. 12 issue of the Journal of the American Medical Association, as does another study, this one finding that Actos (pioglitazone), a diabetes drug in the same class as Avandia, actually reduces the risk of heart attack, stroke and death, even while it increases the risk for serious heart failure.

"This study shows that this drug, used for sugar control, provides an additional benefit of reducing cardiovascular complications," said Dr. A. Michael Lincoff, lead author of the study and vice chairman for research in the department of cardiovascular medicine at the Cleveland Clinic. "This is very strong reassurance."

It's unclear what the new conclusions mean for this class of drugs, called thiazolidinediones. Previous studies have indicated cardiovascular risks, and, in August, the FDA mandated stricter labeling, including "black-box" warnings, for the medications.

"The whole area of thiazolidinediones has been thrown wide open by all these meta-analyses," said Dr. Gregory Dehmer, professor of internal medicine at Texas A&M Health Science Center College of Medicine and director of the cardiology division at Scott & White Hospital in Temple. "For the average clinician in the street, there's a substantial amount of uncertainty, and this is magnified for patients," he said

For the first study, Singh and his colleagues conducted a meta-analysis of four randomized trials of Avandia involving more than 14,000 patients.

In the analysis, Avandia increased the risk of heart attack by 42 percent and doubled the risk of heart failure, similar to findings of a previous study. In this analysis, Avandia did not increase the risk of death from cardiovascular causes, however.

The study received no funding from GlaxoSmithKline, the maker of Avandia.

With an estimated 3.5 million or more U.S. patients taking Avandia, the public health impact could be substantial, the authors point out. This could translate into more than 4,000 excess heart attacks and 9,000 excess heart failure events.

For the second study, also a meta-analysis, Lincoff and his colleagues looked at data from 19 trials involving more than 16,000 participants that looked at Actos and cardiovascular complications.

According to the study authors, Actos' manufacturer, Takeda Pharma, funded the analysis and provided the data from the trials but was not involved in any of the analysis.

Like Avandia, Actos also raised users' risk for heart failure, this time by about 40 percent.

However, unlike Avandia, patients receiving Actos had an 18 percent lower risk of heart attack, stroke or death than patients in the control group.

Why might two drugs in the same class have different effects? "For this type of drug, a 'class' is a really loose term, because the medications have very different actions on multiple targets," Lincoff said. Actos should probably be the first-line choice, over Avandia, he said.

And more trials, namely randomized trials looking at specifically at cardiovascular outcomes, are needed to fully assess the effects of the drugs, Dehmer added.

More information

For more on diabetes drugs, visit the U.S. Food and Drug Administration.



SOURCES: A. Michael Lincoff, M.D., vice chairman for research, department of cardiovascular medicine, Cleveland Clinic; Sonal Singh, M.D., assistant professor of internal medicine, Wake Forest University School of Medicine, Winston-Salem, N.C.; Gregory Dehmer, M.D., professor of internal medicine, Texas A&M Health Science Center College of Medicine and director, cardiology division, Scott & White Hospital, Temple; Sept. 12, 2007, Journal of the American Medical Association


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Diabetes and Depression often go hand-in-hand
3. Vitamin E, the latest warrior against diabetes
4. Thirty minutes of work up per day reduces the risk of Diabetes
5. New Drug for Diabetes
6. Diabetes, obesity rates shooting up
7. Promising Treatment for Diabetes
8. Caffeine Found To Worsen Diabetes
9. Transplant helps diabetes
10. Dissecting Diabetes - Is protein AKT2 the cause of type 2 diabetes?
11. Higher Rates Of Diabetes Found Among The Poor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... Bionic Sports ... all walks of life, announced it had a successful January ECRM Trade Show in ... in the United States, which allows it to provide its products to all clients ...
(Date:1/20/2017)... , ... January 20, 2017 , ... ... products to enhance people’s everyday lives, recently attended the January ECRM Trade Show ... ATP Science is known for its large range of supplements that keep the ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... Michael and ... Dana Farber Cancer Institute. For Betsy, the clinical trial has been life-saving as ... has not worsened. , Betsy Brauser was diagnosed with ovarian cancer in 2009. ...
(Date:1/20/2017)... , ... January 20, 2017 , ... ... and its sugar-free alternative VW+ 002. The drinks have been produced in collaboration ... conditions to perform during your workout. , After a successful launch in Sweden ...
(Date:1/20/2017)... ... 2017 , ... “The Angel”: a heartwarming and earnest tale of faith ... his children. “The Angel” is the creation of published author, Marjorie Lund-Fontaine, a former ... impassioned writer. , When asked of her new book, Marjorie says, “‘The Angel’ was ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 19, 2017 Accuray Incorporated ... CyberKnife® and TomoTherapy® Systems continue to set the bar ... the highest composite overall user satisfaction rating among radiation ... Q4 2016 MD Buyline Market Intelligence Briefing™. The most ... highest composite ratings among industry peers for 11 of ...
(Date:1/19/2017)... , Jan. 19, 2017 ViewRay, Inc. (Nasdaq: ... federal institution supporting research in Germany ... patient treatments at the University Clinic Heidelberg as part ... The MRIdian Linac program will be headed by Medical ... heads radiation oncology at the German Cancer Research Center ...
(Date:1/19/2017)... January 19, 2017 New ... to Address Motor Symptoms and Motor Complications in ... ...      (Logo: http://photos.prnewswire.com/prnh/20151014/276718LOGO) C ... European Neurological Review,2016;11(Suppl. 2): 2-15, http://www.touchneurology.com/articles/safinamide-new-therapeutic-option-address-motor-symptoms-and-motor-complications-mid-late ...
Breaking Medicine Technology: