Navigation Links
Diabetes, Weight Tied to Male Infertility
Date:7/9/2008

Both conditions cause significant decrease in body's ability to repair sperm DNA, studies find

WEDNESDAY, July 9 (HealthDay News) -- Diabetes and being over- or underweight can have a negative effect on male fertility.

That's the conclusion of two reports to be presented July 9 at the annual conference of the European Society of Human Reproduction & Embryology, in Barcelona, Spain.

While semen samples from diabetics look normal under the microscope, a closer examination revealed DNA damage, Dr. Con Mallidis, of Queen's University in Belfast, Northern Ireland, said in a news release issued by the conference sponsors.

"Sperm RNA was significantly altered, and many of the changes we observed are in RNA transcripts involved in DNA repair," he said. "And comparison with a database of men of proven fertility confirmed our findings. Diabetics have a significant decrease in their ability to repair sperm DNA, and once this is damaged, it cannot be restored."

Sperm DNA quality is known to be tied to decreased embryo quality, low embryo implantation rates, higher miscarriage rates and some serious childhood diseases, including cancers.

"We found a class of compounds known as advanced glycation end products (AGEs) in the male reproductive tract. These are formed as the result of glycation (the addition of sugar)," Mallidis said, "and accumulate during normal aging. They are dependent on lifestyle, diet, smoking, etc., and in many diabetic complications are centrally implicated in DNA damage. We believe that they play a similar role in the male reproductive system."

The researchers plan to now determine how AGEs cause and contribute to DNA damage.

Obesity, which often plays a factor in diabetes, and being too thin, was also found to cause problems with sperm. In a separate study, scientists found that men with a higher body mass index (BMI, a ratio of weight to height) had less seminal fluid and more abnormal sperm.

The findings showed that men with an optimal BMI of 20 to 25 had higher levels of normal sperm than those who were either overweight or underweight. They also had higher semen volume.

The researchers did not look at DNA damage in the sperm, though.

"Our findings were quite independent of any other factors," scheduled presenter A. Ghiyath Shayeb, from the University of Aberdeen, in Scotland, said in the news release from the conference, "and seem to suggest that men who are trying for a baby with their partners should first try to achieve an ideal body weight."

"Adopting a healthy lifestyle, a balanced diet, and regular exercise will, in the vast majority of cases, lead to a normal BMI," he said. "We are pleased to be able to add improved semen quality to the long list of benefits that we know are the result of an optimal body weight."

More information

The American Urological Association has more about male infertility.



-- Kevin McKeever



SOURCE: European Society for Human Reproduction & Embryology, news release, July 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Preparation for Natural Disasters Critical for People With Diabetes, Chronic Medical Conditions
2. Health Secretary Promotes Awareness of Diabetes, Urges Healthy Habits
3. With Obesity, Diabetes, and Cardiovascular Disease on the Rise, Physicians Need More Comprehensive Guidelines
4. Diabetes, Growth Disorders Drive Sales of Pediatric Hormone Drugs
5. Coming soon: Cell therapies for diabetes, cancer?
6. Doctors Urged to Look for Link Between Type 2 Diabetes, Sleep Apnea
7. Early Weight Loss in Women Linked to Dementia
8. New research explores newborn in-hospital weight loss
9. Weight-Loss Surgeries Extend Lives
10. School-based overweight prevention program may cut risk of eating disorders among girls
11. Overweight toddlers and those not in day care at risk for iron deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... Long Island, NY (PRWEB) , ... August 16, 2017 , ... ... assist with IV starts and blood draws. By broadly deploying AccuVein devices, Maury Regional ... technology takes much of the guesswork out of a needle stick and more importantly, ...
(Date:8/16/2017)... ... August 16, 2017 , ... LabRoots , the leading ... around the world, is excited to announce Andrew Ly as the winner of the ... covering textbook costs. , Ly, who is in his third year at the ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... ... Endoscopes states: “Drying the endoscope after every reprocessing cycle, both between patient procedures ... transmission and nosocomial infections. Drying is as important to the prevention of disease ...
(Date:8/16/2017)... ... August 16, 2017 , ... Harbor Retirement Associates ... announced today that two of their associates were recognized with individual “Best of ... living communities in Florida. The awards were announced at the 5th Annual 2017 ...
(Date:8/16/2017)... ... ... TopConsumerReviews.com recently gave a best-in-class 5 star rating to Test Country, a leader ... States has undergone major changes over the last decade, particularly when it comes to ... get a blood test or other lab work done. Today, most tests are available ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... , Aug. 3, 2017  Agragen, LLC, ... company active in the biopharmaceutical, nutraceutical, and aquacultural ... development of its lead drug candidates, AGR131.  This ... proinflammatory cytokine from the blood of patients suffering ... and inflammatory bowel disease. ...
(Date:8/2/2017)... 2, 2017  Life Flight Network and PeaceHealth Oregon Network ... patient care and operational efficiency for patients at hospitals in ... Cottage Grove , and Florence, ... and Life Flight Network work collaboratively to move patients who ... when a time sensitive emergency exists. ...
(Date:7/31/2017)... , July 31, 2017 Three Tru-D SmartUVC robots ... South Korea . Tru-D, short for "Total Room Ultraviolet Disinfection," ... rooms after an environmental services (ES) professional cleans the area with traditional ... Tru-D ... "Although the BAACH has ...
Breaking Medicine Technology: