Navigation Links
Developments in TACE and SIRT treatment in patients
Date:4/26/2013

Amsterdam, The Netherlands, Friday 26 April 2013: Data from a number of clinical trials presented today at the International Liver Congress 2013 shed new light on the use of TACE and SIRT in the treatment of hepatocellular carcinoma (HCC).

Transarterial chemoembolization (TACE) is a technique in which small particles designed to block blood vessels mixed or coated with chemotherapeutic drugs are injected directly into an artery supplying the tumour; it has become a standard treatment in selected patients with HCC.

New data presented today has identified a scoring system which defines those HCC patients who achieve the most benefit from TACE. An Assessment for Retreatment with TACE (or ART-score) was developed based on the impact of the initial TACE session on parameters of liver function and tumour response, and their impact on overall survival (overall survival; log rank test).

The ART-score differentiated two groups (0-1.5 points; ≥2.5 points) with distinct differences in prognosis (median overall survival: 23.7 months vs. 6.6 months; p< 0.001) which was confirmed in an independent external validation cohort. In addition, a higher ART-score was associated with major adverse events after the second TACE session (p=0.011).

EASL Vice-Secretary, Prof. Markus Peck-Radosavljevic commented: "These findings represent an important discovery as they will enable physicians to identify and treat those HCC patients who will benefit from repeat TACE sessions. Furthermore, rounds of ineffective treatment, as well as any associated side effects and complications, can be avoided for those patients who are not likely to respond."

While TACE is the standard-of-care treatment for intermediate-stage HCC, selective Internal Radiotherapy Treatment (SIRT) is more commonly used to treat patients with advanced-stage HCC, or those who are poor candidates for, or have failed TACE. However, data from SIRTACE, a separate, open-label, multi-centre pilot study suggest that a single-session of SIRT is as safe and effective as multiple sessions of TACE in a typical TACE patient cohort with unresectable HCC.

Patients were randomised to receive either TACE (n=15) or SIRT (n=13). Patients received a mean of 3.4 TACE interventions (median 2; range 1-11) or 1 SIRT procedure. Treatment response was assessed by local (using RECIST 1.0) and independent central (RECIST 1.1 and mRECIST) review. Median progression-free survival (RECIST 1.1) was 5.5 months (95%CI: 1.6- not reached) for TACE and 4.1 months (95%CI: 2.3-9.9) for SIRT (p=0.411). Overall survival did not differ by procedure (p=0.244).

The similar efficacy and safety of these two procedures presents a challenge for the design of a phase III trial for intermediate-stage HCC in terms of whether to use TACE or SIRT as the preferred treatment technique.

Finally, the SORAMIC European multicentre phase II clinical trial also showcased at the congress, evaluated the efficacy and safety of using a combination of SIRT and sorafenib for the treatment of HCC.

Data from the interim safety analysis has confirmed that SIRT as a sequential approach followed by an escalation scheme for sorafenib does not lead to increased toxicity. Interim analysis of the data showed a total number of adverse events of 196 and 220 in the combination and control arm, with grade 3-5 adverse events reaching 42 and 49, respectively (p>0.05).

SORAMIC continues to recruit and investigators are hopeful that the combination of SIRT and sorafenib will be shown to significantly enhance survival over sorafenib alone without increasing toxicity thus enabling to design large Phase III clinical trials.

Disclaimer: the data referenced in this release is based on the submitted abstract. More recent data may be presented at the International Liver Congress 2013.


'/>"/>

Contact: Dimple Natali
easlpressoffice@cohnwolfe.com
44-079-001-38904
European Association for the Study of the Liver
Source:Eurekalert

Related medicine news :

1. New developments reveal a molecule with a promising function in terms of cancer treatment.
2. Spread of Cancer May be Reduced by Maximizing Melatonin by Blocking Blue Light Says Photonic Developments LLC
3. New Way to Fight the Winter Blues (SAD): Use Glasses from Photonic Developments LLC that Block Blue Light
4. DePuy ASR Hip Replacement Lawsuit Lawyers at Wright & Schulte LLC Report Latest Developments in DePuy ASR Hip Implant Recall Lawsuits
5. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
6. Clinical insight improves treatment with new lung cancer drug
7. Rapid Asthma Treatment in ER May Prevent Admission
8. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
9. Breast cancer patients suffer treatment-related side effects long after completing care
10. Mayo Clinic offers newly approved treatment for acid reflux disease
11. Mobile Stroke Units Might Trim Time to Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... 2017 , ... Parker at Stonegate, an assisted living residence ... caregivers, volunteers, thought leaders, researchers, educators and partners leading the way in services ... refresh the carpeting with the goal of maintaining the same precise colors and ...
(Date:8/18/2017)... ... August 18, 2017 , ... More than 20,000 pairs of ... Congo (DRC) thanks to an ambitious venture that conjoined the passions of an NBA ... support of the Liberty community. These shoes will save lives from the rampant infections ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... edition of “Vision & Hearing,” advocating for active, healthy lifestyles and highlighting the ... available for individuals with hearing impairments and shares the latest innovations in hearing ...
(Date:8/18/2017)... ... 2017 , ... Hernandez Insurance Agencies, a northern Virginia firm ... DC region, is inaugurating a “New Leash On Life” charity initiative in conjunction ... to be companions for veterans in need. , The Semper K9 organization works ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Brian Gifford Agency, an ... is campaigning in support of Campagna Academy in a charity drive to provide for ... Boys’ Town of Indiana,” Campagna Academy is a nonprofit organization that has offered critical ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Pharmaceuticals Inc., the creator of the drug Truveta for the ... an IPO. The United States spends ... a prescription epilepsy drug being $450.00-$1200.00 for a one month supply. ... AXIUM PHARMACEUTICALS, INC ... figure is the fact that Americans spent $42 billion on anxiety medications ...
(Date:8/10/2017)... Aug. 10, 2017  Physical Rehabilitation Network (PRN), acquired the ... Lakewood, Colorado . The reputable clinic will continue ... PT, DPT with his staff of four clinicians. Lipkin received ... and brings over 10 years of experience with a strong ... Belmar PT marks the 10th PRN clinic in and around the ...
(Date:8/7/2017)... , Aug. 7, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Joel Saban as president, effective Aug. 7, 2017. ... has decided to pursue other interests and will serve as ... tenure, Paul has served us in multiple leadership roles since ... in Jun. 2015 and has provided decisive, strategic leadership which ...
Breaking Medicine Technology: