Navigation Links
Development of new corneal cell line provides powerful tool
Date:12/27/2012

Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. Cell loss due to aging or corneal endothelial disorders, such as Fuchs dystrophy, can lead to cornea edema and blindness, resulting in the need for cornea transplants.

Studying human corneal endothelium has been difficult for cell biologists because limited cellular model systems exist and have significant drawbacks. The major drawback is that HCEnC cells do not divide and there is a limited source of these cells both for patient transplantation and for study in the laboratory. This field of study is now easier.

Scientists from the Schepens Eye Research Institute, Mass. Eye and Ear, have developed of HCENC-21 and HCEnC-21T, two novel model systems for human corneal endothelium. Their findings, Telomerase Immortalization of Human Corneal Endothelial Cells Yield Functional Hexagonal Monolayers, are online in the PLOS ONE.

A research team led by Ula Jurkunas, M.D., developed first-of their kind model systems for human corneal endothelium.

"These models mimic very well the critical characteristics and functionalities known from the tissue in the eye," Dr. Jurkunas said. "They also fulfill essential technical requirements, e.g. indefinite number of and a high rate of cell division, to be a powerful tool. They will enable cell biologists to more reliably study human corneal endothelium in health and disease. The ability to enhance HCEnC cell self renewal and growth opens a new window of development of novel regenerative therapies for corneal swelling, hopefully reducing the need for corneal transplantation in the future."


'/>"/>

Contact: Mary Leach
Mary_Leach@meei.harvard.edu
617-573-4170
Massachusetts Eye and Ear Infirmary
Source:Eurekalert

Page: 1

Related medicine news :

1. New Way to Fight the Winter Blues (SAD): Use Glasses from Photonic Developments LLC that Block Blue Light
2. The role of the innate immune cells in the development of type 1 diabetes
3. GMS Talent L P announces Stephen J. Blakesley Speaks to The Organizational Development Network
4. Dr. Neil McLeod, a West Hollywood Dentist, Announces a Development of a New Dental Instrument to Help Dentists Fit Crowns and Onlays More Accurately
5. Spread of Cancer May be Reduced by Maximizing Melatonin by Blocking Blue Light Says Photonic Developments LLC
6. Common anesthetic agents can be harmful for the development of the fetus
7. DNDi is awarded USD 17.3 million from UNITAID to spur development and delivery of child-adapted ARVs
8. Study identifies potential new pathway for drug development
9. Green scientists propose safety testing system for development of new chemicals
10. FDA to Collaborate on Development of Medical Devices
11. Pitt research sheds new light on virus associated with developmental delays and deafness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... 2017 , ... The Texas Cord Blood Bank (TCBB), a program of nonprofit ... at Women’s Hospital at Renaissance in Edinburg for their outstanding efforts in collecting umbilical ... to donate. , “Women’s Hospital at Renaissance has been a collection partner for ...
(Date:4/28/2017)... Boston, MA (PRWEB) , ... April 28, 2017 , ... ... just for older people. “Wearing a hearing aid doesn’t have the stigma it had ... Speech-Language & Hearing Associates of Greater Boston, in a NALA North American Speaker ...
(Date:4/28/2017)... Pensacola, FL (PRWEB) , ... April 28, 2017 ... ... Tampa, Florida are conducting a pilot study of ActiGraph’s CentrePoint Data ... ActiGraph is a leading provider of clinical-grade wearable activity and sleep monitoring solutions ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... skincare and advanced nutraceutical supplements, through its Nova Skin Sciences division, recently ... hydrating benefits of a moisturizer with the power of an anti-aging concentrate. ...
(Date:4/28/2017)... NY (PRWEB) , ... April 28, 2017 , ... ... celebrating its 5th anniversary. SearchLight is the premier online modeling resource for fluorescence ... more than 30,000 active users during last 5 years spanning the globe, SearchLight ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), ... Healthcare Investor Conference 2017 at the Sheraton Hotel in ... Executive Officer of the Company is scheduled to present on Tuesday, ... and the Chairman of the Board, Tony Holler ... ...
(Date:4/19/2017)... , April 19, 2017 Global Surgical Drainage ... are tubes used to remove excess liquid and air. ... pus, urine, bile or lymph. Surgical drains are used ... such as orthopedics surgery, cardiovascular surgery, neurosurgery, plastic surgery ... post-surgery to prevent accumulation of fluid e.g. blood or ...
(Date:4/19/2017)...  Sorrento Therapeutics, Inc. (NASDAQ: SRNE ... new treatments for cancer and other unmet medical ... announced underwritten public offering of 23,625,084 shares of ... of $2.00 per share, before deducting underwriting discounts ... Sorrento.  The net proceeds to Sorrento from this ...
Breaking Medicine Technology: