Navigation Links
Developing a modular, nanoparticle drug delivery system
Date:10/5/2007

There are two aspects to creating an effective drug: finding a chemical compound that has the desired biological effect and minimal side-effects and then delivering it to the right place in the body for it to do its job.

With the support from a $478,000, five-year CAREER award from the National Science Foundation, Eva Harth is tackling the second part of this problem. She is creating a modular, multi-functional drug delivery system that promises simultaneously to enhance the effectiveness and reduce undesirable side-effects of a number of different drugs.

(NSFs Faculty Early Career Development awards are the agencys most prestigious honor for junior faculty members and are given to individuals judged most likely to become the academic leaders of the 21st century.)

Harth, who is an assistant professor of chemistry at Vanderbilt University, has created a nanosponge specially designed to carry large numbers of drug molecules. She has also discovered a molecular transporter that, when attached to the nanosponge, carries it and its cargo across biological barriers into specific intracellular compartments, which are very difficult places for most drugs to reach. She has shown that her system can reach another difficult target: the brain. Experiments have shown that it can pass through the brain-blood barrier. In addition, she has: successfully attached a special targeting unit that delivers drugs to the surface of tumors in the lungs, brain and spinal cord and even developed a light kit for her delivery system fluorescent tags that researchers can use to monitor where it goes.

Harth has taken a different approach from other researchers working on nanotechnology for drug development. Instead of trying to encapsulate drugs in nanoscale containers, she decided to create a nanoparticle that had a large number of surface sites where drug molecules could be attached. To do so, she adopted a method that uses extensive internal cross-linking to scrunch a
'/>"/>

Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New antibiotic already developing resistance
2. Identifying The Risks Of Developing Schizophrenia
3. Patients With Severe Hemophilia At Risk Of Developing Osteoporosis
4. Risk Of Developing Arthritis
5. Periodontal disease may amass the risk of developing Type 2 diabetes
6. Developing HIV fighter
7. Diabetes cases could double in developing countries in next 30 years
8. Antibiotics Found To Increase The Risk Of Developing Breast Cancer
9. The Effectiveness Of Cancer Drug In Women At Risk Of Developing Cancer
10. Men Who at Risk Of Developing Prostate Cancer
11. Cancer Patients At A Greater Risk Of Developing Blood Clots
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... NC (PRWEB) , ... August 29, 2015 , ... ... how mesothelioma develops, may extend and improve the lives of patients, according to ... website. Click here to read the full article. , The authors ...
(Date:8/29/2015)... (PRWEB) , ... August 29, 2015 , ... ... failure, angina, chronic obstructive pulmonary disease (including emphysema), or asthma, are at higher ... as angina, previous heart attack, heart failure or heart-rhythm problems (arrhythmia or irregular ...
(Date:8/28/2015)... ... 28, 2015 , ... Joining a growing number of hospitals ... management companies to partner with Wound Care Advantage (WCA) to utilize the ... , Transitioning wound care management providers can be a complex undertaking. WCA provides ...
(Date:8/28/2015)... ... August 28, 2015 , ... With the goal of furthering music education programs ... to the Adams County Fairgrounds in Mendon, IL on May 30th, 2015. Backed once ... music education in the underfunded school districts of Mendon and its neighboring town of ...
(Date:8/28/2015)... ... ... On May 30th, 2015, Best Drug Rehabilitation, a results-based substance abuse treatment ... benefit concert in Mendon, IL. Held in the Show Barn at the Adams County ... programs in the underfunded local school districts of Mendon at neighboring Quincy, IL. Now ...
Breaking Medicine News(10 mins):Health News:Top Mesothelioma Researchers Highlight Targeted Therapies in New Report, According to Surviving Mesothelioma 2Health News:Heart Fit Clinic Sounds the Alarm on Forest Fire Smoke and Chronic Heart Disease in Calgary Area 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:New Video Released on "Music With A Mission" Benefit Concert Headlining Artist Cadillac Three & Best Drug Rehabilitation 2
... news this week from the World Health Organization (WHO) ... that there is almost a 50% drop of measles ... to the successful vaccination programme being undertaken in developing countries. ... down 39%, from 873 000 in 1999 to an estimated ...
... research shows that people who have optic nerve damage ... disorder.// For the study researchers involved 25 people ... followed for 14 days, and their results were compared ... It was discovered that those with optic nerve disease ...
... hepatitis B virus causes inflammation of the liver and ... //. In most countries, the hepatitis B vaccine is ... for hepatitis B protects against infection for up to ... vaccine protection continues past 10 years. ,Researchers followed ...
... health of the expectant mother. Now a new study ... condition of preeclampsia in the pregnant women. ... together with periodontitis with atherosclerosis to preeclampsia. Such an ... substance abuse like smoking, etc. The basic reason for ...
... study shows folic acid and vitamin B12 are safe and ... patients // after having a stroke . According to researchers ... hip fracture than their healthy peers due to higher levels ... with osteoporosis and risk of hip fracture. ,The ...
... Autism had been on the rise in Japan, even after the ... ,MMR vaccine is one of the must-have vaccines to ... WHO. ,An edition of the journal Lancet in 1998 had ... in children. Based on the report, there had been considerable fall ...
Cached Medicine News:Health News:Drop in Worldwide Measles deaths by 40% 2
(Date:8/28/2015)... 2015 Perrigo Company plc ("Perrigo") (NYSE: ... ("Mylan") (NASDAQ: MYL ) shareholder vote regarding its ... views of Mylan,s offer to Perrigo shareholders have always ... Board,s careful reflection of the value available to Perrigo ... that Mylan has allowed its shareholders to consider," said ...
(Date:8/28/2015)... , August 28, 2015 The report "Eubiotics ... (Pork/Swine, Poultry, Ruminant, and Aquaculture), & by Region ( ... Asia-Pacific , and Rest of the World) - ... global market for Eubiotics was valued at USD 4.62 Billion ... by 2020, at a CAGR of 7.4% from 2015 to ...
(Date:8/27/2015)... , Aug. 27, 2015  A recent study ... Knee Journal, compared the Arthrosurface HemiCAP® Wave implant, ... versus an "onlay" design implant for isolated patellofemoral ... in function and pain scores, none of the ... osteoarthritis (OA). However, 53% of the patients in ...
Breaking Medicine Technology:Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5Eubiotics Market Worth 7.05 Billion USD by 2020 2Eubiotics Market Worth 7.05 Billion USD by 2020 3Eubiotics Market Worth 7.05 Billion USD by 2020 4Eubiotics Market Worth 7.05 Billion USD by 2020 5Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: