Navigation Links
Determining risk for pancreatic cancer
Date:2/24/2009

In the latest clinical trial for a technique to detect pancreatic cancer, researchers found they could differentiate cells that are cancerous from those that are benign, pre-cancerous, or even early stage indicators called mucinous cystic lesions.

Pancreatic cancer is dangerous to screen for, yet deadly if ignored. The pancreas is extremely sensitive--biopsies can lead to potentially fatal complications--but with few symptoms, the cancer is usually detected too late.

The disease is the fourth largest cause of cancer-related deaths in the United States, with a five-year survival rate of less than 5 percent. If doctors can find ways to identify early precursor lesions, the disease can be prevented in most individuals.

Reporting online Feb. 10, 2009, in the journal Disease Markers, researchers from Northwestern University and Evanston Northwestern Healthcare report convincing results with their minimally invasive methods for detecting pancreatic cancer.

"This technique allows us to detect changes in cells that look normal using microscopy," says co-author Vadim Backman of Northwestern University. "This level of detail allows us to detect cancer in its earliest stages."

Their techniques, called four-dimensional elastic light scattering fingerprinting (4D-ELF) and low-coherence enhanced backscattering spectroscopy (LEBS), identify the cancer and its precursors by analyzing light reflected off cells in the duodenum, a section of the small intestine adjacent to the pancreas.

"I'm excited about this work," said Leon Esterowitz, the National Science Foundation (NSF) biophotonics program director who helped fund this study and the development of the 4D-ELF and LEBS technologies. "I believe these results are very promising, and the techniques have a high probability of success for not just detecting early pancreatic cancer, but pre-cancer, so doctors can go ahead and treat the patient while there's still a chance to defeat the disease." Esterowitz added. "For pancreatic cancer, this could lead to not only an excellent prognosis, but perhaps even a cure."

While earlier success had shown that the techniques could tell cancerous from non-cancerous tissue without resorting to a biopsy, the new study of 203 individuals was the first to show the method can identify various disease stages and risk factors, including a possible signature related to "family history."

The researchers' approach had a sensitivity of 95 percent for determining healthy tissue from cancerous tissue and appears to be the most successful yet developed for detecting pancreatic diseases at curable stages and for identifying high-risk individuals.

"These optical techniques have shown promise for detecting both colon and pancreatic cancer," says Backman. "Our hope is to continue to test the ability to detect other forms of cancer, which would greatly expand the impact of the technology." In ongoing work, the researchers will continue to refine their instrumentation and hope to validate the recent findings with further clinical trials.


'/>"/>

Contact: Joshua A. Chamot
jchamot@nsf.gov
703-292-7730
National Science Foundation
Source:Eurekalert

Related medicine news :

1. NEJM Report Finds HPV Test More Effective Than Pap in Determining Cervical Cancer Risk
2. CSHL scientists make progress in determining how the brain selectively interprets sound
3. New method proposed for determining which patients should get treatment for colorectal cancer
4. New Method Proposed for Determining Which Patients Should Get Treatment for Colorectal Cancer
5. Determining genetic signature of lung tumors can help guide treatment
6. Fitness a Key Element in Determining Male Diabetics Longevity
7. PET/CT scan could be valuable noninvasive tool for determining stages of ovarian cancer
8. Past Earnings Play Role in Determining SSDI Benefits
9. Determining Valuations in Challenging Times
10. Gender is key factor in determining overall survival of lung cancer patients
11. Cancer stem cell subpopulation drives metastasis of human pancreatic cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... NY (PRWEB) , ... October 13, 2017 , ... Ellevate ... people in business to advocate for action towards gender equality at their inaugural Summit ... from around the globe, and reached a social audience of over 3 million. To ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  BioPharmX Corporation (NYSE MKT: BPMX) ... developed an innovative way to use nonlinear optical imaging ... of new drugs. ... Conference will show how researchers from BioPharmX and the ... School used a suite of imaging techniques in what ...
(Date:10/10/2017)... Oct. 10, 2017  NDS received FDA 510(k) clearance in May ... battery-powered display stand specifically designed for endoscopy environments. An innovative secondary ... a clinical solution to support the improvement of patient outcomes, procedural ... ... ...
(Date:10/4/2017)... Korea , Oct. 4, 2017  South Korean-based ... next-generation CPR training aide "cprCUBE" on Kickstarter. The device ... compression during cardiac arrests with better efficiency compared to ... also offers real-time feedback on efficacy of the compression ... crowdfunding campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: