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Detecting cocaine 'naturally'
Date:2/13/2013

tify the precise amount of thousand of molecules in seconds," explains Professor Valle-Blisle. "We therefore decided to adapt these inhibition, activation, and sequestration mechanisms to improve the efficiency of artificial biosensors."

The researchers put their idea to the test by using an existing cocaine biosensor and revising its design so that it would respond to a series of inhibitor molecules. They were able to adapt the biosensor to respond optimally even with a large concentration window. "What is fascinating," says Alessandro Porchetta, a doctoral student at the University of Rome, "is that we were successful in controlling the interactions of this system by mimicking mechanisms that occur naturally."

"Besides the obvious applications in biosensor design, I think this work will pave the way for important applications related to the administration of cancer-targeting drugs, an area of increasing importance," says Professor Kevin Plaxco. "The ability to accurately regulate biosensor or nanomachine's activities will greatly increase their efficiency."


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Contact: Julie Gazaille
j.cordeau-gazaille@umontreal.ca
514-343-6796
University of Montreal
Source:Eurekalert

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