Navigation Links
Detecting bias in the reporting of clinical trials

A study by researchers at the University of Leicester has revealed new ways to spot whether medical research has hidden biases. Writing in the prestigious British Medical Journal, Santiago Moreno and his colleagues demonstrate how to spot 'publication bias' in the reporting of clinical trials which potentially form the basis of Government and NHS health policies. They also show what mathematical adjustments can be made to remove such unintended distortion of data.

Health policies are founded on 'clinical trials': experiments done in a laboratory or with groups of patients, which produce statistical results (because no two individuals are alike). Experimental results are published in medical journals after being thoroughly checked to ensure that all the methods used were fair and accurate but 'publication bias' can affect what gets published.

For example, trials with negative results showing that a treatment doesn't work may be less likely to be published than those showing that it does. And this can create a distorted view of the treatment's effectiveness when policy-makers have to decide on whether it is worthwhile.

The University of Leicester researchers- examined two new methods of statistical analysis, using data on anti-depressant use available from the United States' Food and Drug Administration (FDA). The FDA's data is considered 'gold standard' free from bias so it can be used to check whether statistics collected from journals, when adjusted, provide a true picture.

Both methods investigated by the Leicester team proved effective in identifying and eliminating publication bias from medical research.

Santiago's colleagues in the research project were Professor Alex Sutton, Professor Keith Abrams and Dr Nicola Cooper, from the Department of Health Sciences, plus collaborators at the Universities of Bristol and Oregon.


Contact: Alex Sutton
University of Leicester

Page: 1

Related medicine news :

1. Detecting early signs of osteoarthritis
2. Detecting Diabetes Without a Needle: The Spit Factor
3. Detecting Potentially Violent Behavior in the Workplace
4. Optical techniques show continued promise in detecting pancreatic cancer
5. Scripps research scientists develop general-purpose method for detecting trace chemicals
6. University of the Basque Country team develop nano-hydrogels capable of detecting cancer cells
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. IK4 develops a portable device for detecting Salmonella in under an hour
9. New mammography technology effective in detecting breast cancer
10. Dairy Veterinarians Highlight Need for Improved Methods for Detecting Mastitis
11. Paul Sullivans Legacy: An Early Warning Program for Detecting Melanoma Before Its Too Late
Post Your Comments:
(Date:10/12/2015)... ... October 12, 2015 , ... ... secured a new corporate headquarters, located at 485 Madison Avenue, New York, NY ... and increased emphasis on cloud-based technology. , “Care to Care is a dynamic ...
(Date:10/12/2015)... ... October 12, 2015 , ... In the first known ... individuals involved in nursing research spent as much as the equivalent of four 40-hour ... a single successful National Institutes of Health (NIH) grant application for funds to conduct ...
(Date:10/12/2015)... ... October 12, 2015 , ... CMS’s just-released 2016 Medicare ... partners to assess and act on, indicating which stars measures are causing plans the ... Part D health plans should focus their efforts and how CMS intends to modify ...
(Date:10/12/2015)... ... October 12, 2015 , ... T.E.N., a technology ... evening, October 8, at the 2015 ISE® Northeast Executive Forum and Awards ... , Michael Towers, VP, executive information security officer for Allergan, was selected as ...
(Date:10/12/2015)... ... October 12, 2015 , ... On Sunday, October 18, the Sierra Regional Spine ... in support of all Washoe County students. This is the first time the institute ... Sparks Marina outlet mall outside Reno, Nevada. , The family and youth-focused event features ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... ) ... "Personalized Medicine, Targeted Therapeutics and Companion Diagnostic ... Industry Trends, Technologies, Participants, and Environment" ... ) has announced the addition of ... Companion Diagnostic Market to 2019 - Strategic ...
(Date:10/12/2015)... St. Paul, Minn. , Oct. 12, 2015 /PRNewswire/ ... with it, a need to help integrate these devices ... global leader of ergonomic healthcare mounting and mobility solutions, ... Carts, its lightest cart yet, for a wide array ... StyleView S-Tablet Cart SV10 was developed exclusively for Microsoft ...
(Date:10/12/2015)... 12, 2015 ... grow at 7.2% CAGR, microscopy market growth ... focus on nanotechnology, technological advancements, and increasing ... available with ... --> Complete report on microscopy ...
Breaking Medicine Technology: