Navigation Links
Detecting bias in the reporting of clinical trials
Date:8/19/2009

A study by researchers at the University of Leicester has revealed new ways to spot whether medical research has hidden biases. Writing in the prestigious British Medical Journal, Santiago Moreno and his colleagues demonstrate how to spot 'publication bias' in the reporting of clinical trials which potentially form the basis of Government and NHS health policies. They also show what mathematical adjustments can be made to remove such unintended distortion of data.

Health policies are founded on 'clinical trials': experiments done in a laboratory or with groups of patients, which produce statistical results (because no two individuals are alike). Experimental results are published in medical journals after being thoroughly checked to ensure that all the methods used were fair and accurate but 'publication bias' can affect what gets published.

For example, trials with negative results showing that a treatment doesn't work may be less likely to be published than those showing that it does. And this can create a distorted view of the treatment's effectiveness when policy-makers have to decide on whether it is worthwhile.

The University of Leicester researchers- examined two new methods of statistical analysis, using data on anti-depressant use available from the United States' Food and Drug Administration (FDA). The FDA's data is considered 'gold standard' free from bias so it can be used to check whether statistics collected from journals, when adjusted, provide a true picture.

Both methods investigated by the Leicester team proved effective in identifying and eliminating publication bias from medical research.

Santiago's colleagues in the research project were Professor Alex Sutton, Professor Keith Abrams and Dr Nicola Cooper, from the Department of Health Sciences, plus collaborators at the Universities of Bristol and Oregon.


'/>"/>

Contact: Alex Sutton
ajs22@le.ac.uk
44-116-229-7268
University of Leicester
Source:Eurekalert

Page: 1

Related medicine news :

1. Detecting early signs of osteoarthritis
2. Detecting Diabetes Without a Needle: The Spit Factor
3. Detecting Potentially Violent Behavior in the Workplace
4. Optical techniques show continued promise in detecting pancreatic cancer
5. Scripps research scientists develop general-purpose method for detecting trace chemicals
6. University of the Basque Country team develop nano-hydrogels capable of detecting cancer cells
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. IK4 develops a portable device for detecting Salmonella in under an hour
9. New mammography technology effective in detecting breast cancer
10. Dairy Veterinarians Highlight Need for Improved Methods for Detecting Mastitis
11. Paul Sullivans Legacy: An Early Warning Program for Detecting Melanoma Before Its Too Late
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... A new white paper by The Beryl Institute ... long-term care environment as well as provides recommendations for ... “The Power of Person-Centeredness in Long-Term Care: A View ... patient, resident and family experience in long-term care and ...
(Date:1/22/2015)... January 22, 2015 Autocarinsurancebest.com has released a ... a commercial auto insurance policy . , Auto insurance ... vehicles. It is no longer necessary to call an agent ... now available online on a single website: http://autocarinsurancebest.com/ . ...
(Date:1/22/2015)... has released a new blog post presenting the basic features ... Purchasing an accidental death and dismemberment rider for a car ... provides benefits if the insured dies in an accident. Accidental ... life insurance. , AD&D is not expensive and can ...
(Date:1/22/2015)... NY (PRWEB) January 22, 2015 ... of Sports Medicine flagship journal Medicine & Science ... L-Citrulline before exercise may help reduce gastrointestinal (GI) ... 1 , Participants in the double-blind, placebo-controlled ...
(Date:1/22/2015)... has added many trendy Champagne wedding dresses to ... the past three years. Today, the business announces a special ... the sales manager of the company, this is on the ... point can be reflected on the discounted wedding dresses from ...
Breaking Medicine News(10 mins):Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2
... fasciitis can lead to other problems, doctor says , WEDNESDAY, ... bring to mind tennis elbow and jogger,s knee, but the ... due to overuse, doctors warn. , The condition, plantar fasciitis, ... foot, can become chronic if steps aren,t taken to relieve ...
... ... communication with hospital administrators and doctors seeking practice opportunities. , ... Alpharetta, GA (Vocus) December 29, 2009 -- ... extending a singing holiday greeting to over 300,000 hospital administrators, physician recruiters, doctors and ...
... doctor warns , WEDNESDAY, Dec. 30 (HealthDay News) -- Skiing can ... risky, experts say. , Many skiers have learned the hard way ... trip, and the chances of getting hurt aren,t based solely on ... the U.S. Ski Association and Olympic Ski Team and an orthopedic ...
... ... Aaron Boone will be featured on January,s episode of Sharing Miracles ... and inspirational stories of real patients. Sharing Miracles airs every ... of one of only three families in history to have three generations ...
... SPRINGFIELD, Ohio, Dec. 30 AdCare Health Systems, Inc. (NYSE ... P. Gentry and Joshua J. McClellan to its Board of ... of the Board, stated that "Boyd Gentry and Josh McClellan ... care operating and financial experience. Tenwick continued, "with our ...
... small and one expert believes more research is needed , ... good as standard medication to ease hot flashes and other ... as an added bonus, the needle treatment may boost the ... "I think the data shows you that acupuncture is a ...
Cached Medicine News:Health News:Heel Pain Usually Relieved With Stretching Regimen 2Health News:Jackson & Coker Produces Online Video Holiday Message for Hospitals and Medical Providers 2Health News:Jackson & Coker Produces Online Video Holiday Message for Hospitals and Medical Providers 3Health News:If Ski Injury Occurs, Plans for Fun Go Downhill Fast 2Health News:'Sharing Miracles' Television Program to Feature Major League Baseball Star Aaron Boone 2Health News:'Sharing Miracles' Television Program to Feature Major League Baseball Star Aaron Boone 3Health News:'Sharing Miracles' Television Program to Feature Major League Baseball Star Aaron Boone 4Health News:'Sharing Miracles' Television Program to Feature Major League Baseball Star Aaron Boone 5Health News:'Sharing Miracles' Television Program to Feature Major League Baseball Star Aaron Boone 6Health News:'Sharing Miracles' Television Program to Feature Major League Baseball Star Aaron Boone 7Health News:'Sharing Miracles' Television Program to Feature Major League Baseball Star Aaron Boone 8Health News:AdCare Health Systems Names Boyd Gentry and Josh McClellan to its Board 2Health News:AdCare Health Systems Names Boyd Gentry and Josh McClellan to its Board 3Health News:Acupuncture May Cut Hot Flashes, Boost Sex Drive in Breast Cancer Patients 2
(Date:1/22/2015)... Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" ... on Omega-3 therapies for cardiovascular disease and overall health is ... accomplishments in 2014 and its outlook for 2015 from the ... Shareholders, We would like to take this opportunity ...
(Date:1/22/2015)... 22, 2015  Bio-Techne Corporation (NASDAQ: TECH ) ... member of the new Simple Plex platform through its ... represents the re-branding of the previously acquired CyPlex instrument ... is a transformative immunoassay technology which integrates an innovatively ...
(Date:1/22/2015)... Calif. , Jan. 22, 2015 Increasing sophistication ... continued consolidation of localization purchasing in 2015, says ... According to a recent study by market research firm ... a single-source solution for their translation and localization needs. ...
Breaking Medicine Technology:Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2
... NORFOLK, Va., Nov. 17, 2011 MedStar Health, Novant ... to reduce their supply expenses and improve operational performance. ... it has been named, represents more than $3 billion ... will work as a single entity on identified contracting ...
... Hill-Rom Holdings, Inc., (NYSE: HRC ) invites ... Piper Jaffray Health Care Conference in New York City ... You are invited to listen to the live ... or access it directly at http://www.corporate-ir.net/ireye/conflobby.zhtml?ticker=HRC&item_id=4228792 .  A ...
Cached Medicine Technology:Three Large Not-for-profit Healthcare Systems Form New Supply Network 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: