Navigation Links
Detecting bias in the reporting of clinical trials
Date:8/19/2009

A study by researchers at the University of Leicester has revealed new ways to spot whether medical research has hidden biases. Writing in the prestigious British Medical Journal, Santiago Moreno and his colleagues demonstrate how to spot 'publication bias' in the reporting of clinical trials which potentially form the basis of Government and NHS health policies. They also show what mathematical adjustments can be made to remove such unintended distortion of data.

Health policies are founded on 'clinical trials': experiments done in a laboratory or with groups of patients, which produce statistical results (because no two individuals are alike). Experimental results are published in medical journals after being thoroughly checked to ensure that all the methods used were fair and accurate but 'publication bias' can affect what gets published.

For example, trials with negative results showing that a treatment doesn't work may be less likely to be published than those showing that it does. And this can create a distorted view of the treatment's effectiveness when policy-makers have to decide on whether it is worthwhile.

The University of Leicester researchers- examined two new methods of statistical analysis, using data on anti-depressant use available from the United States' Food and Drug Administration (FDA). The FDA's data is considered 'gold standard' free from bias so it can be used to check whether statistics collected from journals, when adjusted, provide a true picture.

Both methods investigated by the Leicester team proved effective in identifying and eliminating publication bias from medical research.

Santiago's colleagues in the research project were Professor Alex Sutton, Professor Keith Abrams and Dr Nicola Cooper, from the Department of Health Sciences, plus collaborators at the Universities of Bristol and Oregon.


'/>"/>

Contact: Alex Sutton
ajs22@le.ac.uk
44-116-229-7268
University of Leicester
Source:Eurekalert

Page: 1

Related medicine news :

1. Detecting early signs of osteoarthritis
2. Detecting Diabetes Without a Needle: The Spit Factor
3. Detecting Potentially Violent Behavior in the Workplace
4. Optical techniques show continued promise in detecting pancreatic cancer
5. Scripps research scientists develop general-purpose method for detecting trace chemicals
6. University of the Basque Country team develop nano-hydrogels capable of detecting cancer cells
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. IK4 develops a portable device for detecting Salmonella in under an hour
9. New mammography technology effective in detecting breast cancer
10. Dairy Veterinarians Highlight Need for Improved Methods for Detecting Mastitis
11. Paul Sullivans Legacy: An Early Warning Program for Detecting Melanoma Before Its Too Late
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... New York (PRWEB) , ... January 24, 2017 , ... ... Brazilian butt lifts is on the rise. According to the American Society of ... since 2000. On average, these procedures are performed every 30 minutes of every day. ...
(Date:1/24/2017)... ... 24, 2017 , ... PeroxyChem Food and Beverage Safety announced ... at the International Production and Processing Expo (IPPE) in Atlanta, Georgia from Jan. ... that is used in poultry processing facilities to provide constant, real-time data that ...
(Date:1/24/2017)... ... January 24, 2017 , ... Twelve startups ... of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired by Under Armour Founder and ... The entrepreneurs will showcase their businesses on February 6, 2017, at Under Armour’s ...
(Date:1/24/2017)... ... ... Bellus Medical, a leader in medical aesthetics, today announced that Marek Dobke, M.D., ... will provide physician oversight for in-house clinical studies and hands-on device training, among other ... Professor of Surgery at UC San Diego Health and is a board certified plastic ...
(Date:1/24/2017)... Boston, MA (PRWEB) , ... January 24, 2017 ... ... What They Really Need to Thrive , Well-meaning studies such as the Fordham ... and schools can better serve top students, such as including gifted or high-achieving ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... , Jan. 24, 2017   Intrexon Corporation ... and industrialization of biology to improve the quality of life ... entered into a definitive agreement to acquire GenVec, Inc ... pioneer in the development of AdenoVerse™ gene delivery technology.  ... expertise in adenoviral vectors and cGMP drug product manufacturing to ...
(Date:1/24/2017)... 24, 2017   Keneric Healthcare , a ... effective patient care products, today announced their partnership ... the reach of both companies by leveraging their ... Angelini Pharma Inc . ... include Keneric Healthcare,s RTD™ Wound Dressing (antibacterial/antifungal).  RTD™ ...
(Date:1/24/2017)... 2017 Stock-Callers.com today has issued research ... ZTS ), Mallinckrodt PLC (NYSE: MNK ), ... Inc. (NYSE: DPLO ). According to pharmaceutical manufacturer ... 2017 for the Generic Drugs industry, including a possible reduction ... current growth, and a speedier FDA approval process that could ...
Breaking Medicine Technology: