Navigation Links
Detecting bias in the reporting of clinical trials

A study by researchers at the University of Leicester has revealed new ways to spot whether medical research has hidden biases. Writing in the prestigious British Medical Journal, Santiago Moreno and his colleagues demonstrate how to spot 'publication bias' in the reporting of clinical trials which potentially form the basis of Government and NHS health policies. They also show what mathematical adjustments can be made to remove such unintended distortion of data.

Health policies are founded on 'clinical trials': experiments done in a laboratory or with groups of patients, which produce statistical results (because no two individuals are alike). Experimental results are published in medical journals after being thoroughly checked to ensure that all the methods used were fair and accurate but 'publication bias' can affect what gets published.

For example, trials with negative results showing that a treatment doesn't work may be less likely to be published than those showing that it does. And this can create a distorted view of the treatment's effectiveness when policy-makers have to decide on whether it is worthwhile.

The University of Leicester researchers- examined two new methods of statistical analysis, using data on anti-depressant use available from the United States' Food and Drug Administration (FDA). The FDA's data is considered 'gold standard' free from bias so it can be used to check whether statistics collected from journals, when adjusted, provide a true picture.

Both methods investigated by the Leicester team proved effective in identifying and eliminating publication bias from medical research.

Santiago's colleagues in the research project were Professor Alex Sutton, Professor Keith Abrams and Dr Nicola Cooper, from the Department of Health Sciences, plus collaborators at the Universities of Bristol and Oregon.


Contact: Alex Sutton
University of Leicester

Page: 1

Related medicine news :

1. Detecting early signs of osteoarthritis
2. Detecting Diabetes Without a Needle: The Spit Factor
3. Detecting Potentially Violent Behavior in the Workplace
4. Optical techniques show continued promise in detecting pancreatic cancer
5. Scripps research scientists develop general-purpose method for detecting trace chemicals
6. University of the Basque Country team develop nano-hydrogels capable of detecting cancer cells
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. IK4 develops a portable device for detecting Salmonella in under an hour
9. New mammography technology effective in detecting breast cancer
10. Dairy Veterinarians Highlight Need for Improved Methods for Detecting Mastitis
11. Paul Sullivans Legacy: An Early Warning Program for Detecting Melanoma Before Its Too Late
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... Bcureful—a non-profit ... as well as raising public awareness of the disorder while helping to bring ... donation of $35,000 to bolster progress at the Tuberous Sclerosis Complex Center at ...
(Date:11/24/2015)... , ... November 25, 2015 , ... ... monitoring. Their Care Plan software creates an agreement between the practice owner ... plan, including financial, scheduling, monitoring, notification, and projections. Click here ...
(Date:11/24/2015)... ... November 24, 2015 , ... Young patients with a wide variety of dental ... Dr. Kedar S. Lele, who are pediatric dentists in Tucson, AZ . Unlike ... iPlus 2.0™ system causes minimal discomfort and bleeding to the patient during treatment and ...
(Date:11/24/2015)... , ... November 25, 2015 , ... ... and development solutions for drugs, biologics, consumer health and global clinical supply services, ... at the upcoming Clinical Trial Supply East Asia Conference, to be held at ...
(Date:11/24/2015)... ... November 24, 2015 , ... It takes only three to five ... is critical that the first impression be positive and reflects business values. If a ... buy anything or want to return. They will also share their thoughts about a ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Nov. 24, 2015  Natera, Inc. (Nasdaq: ... genetic testing and the analysis of circulating ... present at the 27 th  Annual Piper ... 2015 at 1:00 p.m. ET.  Matthew Rabinowitz, Ph.D., CEO of ... business activities and financial outlook. ...
(Date:11/24/2015)... COMMACK, New York , 24. November ... Hersteller des Avery Breathing Pacemaker Systems, ist ... Ph.D., als Clinical Consultant bekannt geben zu ... -->   --> ... Stockholm (Schweden). Von 1984-1986 ...
(Date:11/24/2015)... --  HeartWare International, Inc . (NASDAQ: HTWR ), ... that are revolutionizing the treatment of advanced heart failure, ... Doug Godshall is scheduled to present at the ... December 1, 2015 at 3:00 p.m. ET.  The conference ... York . .  A ...
Breaking Medicine Technology: