Navigation Links
Detecting bias in the reporting of clinical trials
Date:8/19/2009

A study by researchers at the University of Leicester has revealed new ways to spot whether medical research has hidden biases. Writing in the prestigious British Medical Journal, Santiago Moreno and his colleagues demonstrate how to spot 'publication bias' in the reporting of clinical trials which potentially form the basis of Government and NHS health policies. They also show what mathematical adjustments can be made to remove such unintended distortion of data.

Health policies are founded on 'clinical trials': experiments done in a laboratory or with groups of patients, which produce statistical results (because no two individuals are alike). Experimental results are published in medical journals after being thoroughly checked to ensure that all the methods used were fair and accurate but 'publication bias' can affect what gets published.

For example, trials with negative results showing that a treatment doesn't work may be less likely to be published than those showing that it does. And this can create a distorted view of the treatment's effectiveness when policy-makers have to decide on whether it is worthwhile.

The University of Leicester researchers- examined two new methods of statistical analysis, using data on anti-depressant use available from the United States' Food and Drug Administration (FDA). The FDA's data is considered 'gold standard' free from bias so it can be used to check whether statistics collected from journals, when adjusted, provide a true picture.

Both methods investigated by the Leicester team proved effective in identifying and eliminating publication bias from medical research.

Santiago's colleagues in the research project were Professor Alex Sutton, Professor Keith Abrams and Dr Nicola Cooper, from the Department of Health Sciences, plus collaborators at the Universities of Bristol and Oregon.


'/>"/>

Contact: Alex Sutton
ajs22@le.ac.uk
44-116-229-7268
University of Leicester
Source:Eurekalert

Page: 1

Related medicine news :

1. Detecting early signs of osteoarthritis
2. Detecting Diabetes Without a Needle: The Spit Factor
3. Detecting Potentially Violent Behavior in the Workplace
4. Optical techniques show continued promise in detecting pancreatic cancer
5. Scripps research scientists develop general-purpose method for detecting trace chemicals
6. University of the Basque Country team develop nano-hydrogels capable of detecting cancer cells
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. IK4 develops a portable device for detecting Salmonella in under an hour
9. New mammography technology effective in detecting breast cancer
10. Dairy Veterinarians Highlight Need for Improved Methods for Detecting Mastitis
11. Paul Sullivans Legacy: An Early Warning Program for Detecting Melanoma Before Its Too Late
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... May 05, 2016 , ... TLC Laser Eye Centers ... California. The laser eye center will now be called “Gordon Schanzlin New Vision Institute, ... will remain at the full-service facility to ensure that patients continue to receive the ...
(Date:5/5/2016)... Stockholm/San Jose (PRWEB) , ... May 05, 2016 , ... ... the art of self-love. Every day, LELO fans reach out via email, social media ... recurring question keeps upcoming up: “Is the way I masturbate ‘normal’ or ‘correct’?” , ...
(Date:5/5/2016)... Collins, CO (PRWEB) , ... May 05, 2016 ... ... announced the commencement of a master charity program created to assist the people ... 60 days, working closely with nonprofit organizations and community leaders. Their hope is ...
(Date:5/5/2016)... ... May 05, 2016 , ... Vitenas Cosmetic Surgery has been named as ... the American Institute of Architects and the Academy of Architecture for Health. The building, ... Harrell Architects, opened to patients in October of 2014. , The ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... Jennifer Drago presented a talk highlighting the organization’s successful Care Transitions ... Chicago. , The talk was titled “Minimizing Costs in the Post-Acute Environment Through ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... -- Research and Markets has announced the addition ... USA"  report to their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Positron Emission Tomography (PET) scanner and cyclotron install base ... with the current known number of PET scanners and ... report also contains a detailed breakdown of this equipment ...
(Date:5/5/2016)... 5, 2016 ... of the  "Europe Thrombocytopenia Market and ... to their offering.       ... ,The latest research Europe Thrombocytopenia Market ... provides comprehensive insights into Thrombocytopenia pipeline ...
(Date:5/4/2016)... Diversified Holdings (NYSE: CODI ) ("CODI," "we," ... market businesses, announced today its consolidated operating results for ... First Quarter 2016 Highlights , Generated Cash Flow ... of $13.6 million for the first quarter of 2016; ... the first quarter of 2016; , Paid a ...
Breaking Medicine Technology: