Navigation Links
Detecting bias in the reporting of clinical trials

A study by researchers at the University of Leicester has revealed new ways to spot whether medical research has hidden biases. Writing in the prestigious British Medical Journal, Santiago Moreno and his colleagues demonstrate how to spot 'publication bias' in the reporting of clinical trials which potentially form the basis of Government and NHS health policies. They also show what mathematical adjustments can be made to remove such unintended distortion of data.

Health policies are founded on 'clinical trials': experiments done in a laboratory or with groups of patients, which produce statistical results (because no two individuals are alike). Experimental results are published in medical journals after being thoroughly checked to ensure that all the methods used were fair and accurate but 'publication bias' can affect what gets published.

For example, trials with negative results showing that a treatment doesn't work may be less likely to be published than those showing that it does. And this can create a distorted view of the treatment's effectiveness when policy-makers have to decide on whether it is worthwhile.

The University of Leicester researchers- examined two new methods of statistical analysis, using data on anti-depressant use available from the United States' Food and Drug Administration (FDA). The FDA's data is considered 'gold standard' free from bias so it can be used to check whether statistics collected from journals, when adjusted, provide a true picture.

Both methods investigated by the Leicester team proved effective in identifying and eliminating publication bias from medical research.

Santiago's colleagues in the research project were Professor Alex Sutton, Professor Keith Abrams and Dr Nicola Cooper, from the Department of Health Sciences, plus collaborators at the Universities of Bristol and Oregon.


Contact: Alex Sutton
University of Leicester

Page: 1

Related medicine news :

1. Detecting early signs of osteoarthritis
2. Detecting Diabetes Without a Needle: The Spit Factor
3. Detecting Potentially Violent Behavior in the Workplace
4. Optical techniques show continued promise in detecting pancreatic cancer
5. Scripps research scientists develop general-purpose method for detecting trace chemicals
6. University of the Basque Country team develop nano-hydrogels capable of detecting cancer cells
7. Biomarker Combination and Risk of Ovarian Malignancy Algorithm (Roma(TM)) Demonstrates Accuracy in Detecting Ovarian Cancer
8. IK4 develops a portable device for detecting Salmonella in under an hour
9. New mammography technology effective in detecting breast cancer
10. Dairy Veterinarians Highlight Need for Improved Methods for Detecting Mastitis
11. Paul Sullivans Legacy: An Early Warning Program for Detecting Melanoma Before Its Too Late
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), an ... showcase a range of technology and learning solutions at the 68th Annual American ... to be held October 14–18, 2017 at the Mandalay Bay Resort in Las ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... Sept. 27, 2017  Commended for their devotion to personalized ... Ranked as number one in the South Florida Business Journal,s ... Inc. 5000 yearly list, the national specialty pharmacy has found ... Bardisa will soon be honored by SFBJ as the ... Set to receive his award in October, Bardisa ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
(Date:9/18/2017)... Sept. 18, 2017 EpiVax, Inc. ... bioinformatics and immune engineering, today announced a ... A (H7N9) vaccine. ... seasonal influenza and presents a challenge for ... exposure to be effective. Using state-of-the-art bioinformatics and ...
Breaking Medicine Technology: