Navigation Links
Detecting autism from brain activity
Date:4/17/2013

Neuroscientists from Case Western Reserve University School of Medicine and the University of Toronto have developed an efficient and reliable method of analyzing brain activity to detect autism in children. Their findings appear today in the online journal PLOS ONE.

The researchers recorded and analyzed dynamic patterns of brain activity with magnetoencephalography (MEG) to determine the brain's functional connectivity that is, its communication from one region to another. MEG measures magnetic fields generated by electrical currents in neurons of the brain.

Roberto Fernndez Galn, PhD, an assistant professor of neurosciences at Case Western Reserve and an electrophysiologist seasoned in theoretical physics led the research team that detected autism spectrum disorder (ASD) with 94 percent accuracy. The new analytic method offers an efficient, quantitative way of confirming a clinical diagnosis of autism.

"We asked the question, 'Can you distinguish an autistic brain from a non-autistic brain simply by looking at the patterns of neural activity?' and indeed, you can," Galn said. "This discovery opens the door to quantitative tools that complement the existing diagnostic tools for autism based on behavioral tests."

In a study of 19 childrennine with ASD141 sensors tracked the activity of each child's cortex. The sensors recorded how different regions interacted with each other while at rest, and compared the brain's interactions of the control group to those with ASD. Researchers found significantly stronger connections between rear and frontal areas of the brain in the ASD group; there was an asymmetrical flow of information to the frontal region, but not vice versa.

The new insight into the directionality of the connections may help identify anatomical abnormalities in ASD brains. Most current measures of functional connectivity do not indicate the interactions' directionality.

"It is not just who is connected to whom, but rather who is driving whom," Galn said.

Their approach also allows them to measure background noise, or the spontaneous input driving the brain's activity while at rest. A spatial map of these inputs demonstrated there was more complexity and structure in the control group than the ASD group, which had less variety and intricacy. This feature offered better discrimination between the two groups, providing an even stronger measure of criteria than functional connectivity alone, with 94 percent accuracy.

Case Western Reserve's Office of Technology Transfer has filed a provisional patent application for the analysis' algorithm, which investigates the brain's activity at rest. Galn and colleagues hope to collaborate with others in the autism field with emphasis on translational and clinical research.

Galn's collaborators and co-authors of this study are University of Toronto's associate researcher, Luis Garca Domnguez, PhD, and professor Jos Luis Prez Velzquez, PhD.


'/>"/>

Contact: Jessica Studeny
jessica.studeny@case.edu
216-368-4692
Case Western Reserve University
Source:Eurekalert

Related medicine news :

1. Dentists Play Key Role in Detecting Oral Cancer
2. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
3. Studies See Advances in Detecting, Treating Pancreatic Cancer
4. New technology represents next-generation tool for detecting substandard and counterfeit medicines
5. Detecting thyroid disease by computer
6. Pharmacists provide additional line of defense for detecting knee osteoarthritis
7. New biomarker may help in detecting gliomas, reports Neurosurgery
8. Amyloid imaging shows promise for detecting cardiac amyloidosis
9. Detecting cocaine naturally
10. Handheld device for detecting counterfeit and substandard medicines tested by PQM
11. Detecting circulating tumor cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... 2016 , ... Love is in the air at King Kullen! The local ... packaging. This staple for Valentine’s Day is a must-have, and can be picked up ... not only are long-stem roses available, but also other flower bouquets, elegantly wrapped and ...
(Date:2/5/2016)... MN (PRWEB) , ... February 05, 2016 , ... The ... at the Day Block Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund ... Larry Schneiderman, owner of Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect ...
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University ... Allen have signed a joint enrollment and degree completion agreement. The agreement, ... and baccalaureate degrees at FHU|Dickson. , The agreement allows students to be ...
(Date:2/5/2016)... ... February 05, 2016 , ... In the ... the country gathered at the La Valencia Hotel in San Diego, California to ... was named the year’s most outstanding franchise, walking away with the coveted David ...
(Date:2/5/2016)... , ... February 05, 2016 , ... Boar’s Head Brand®, ... in time for this weekend’s Big Game. Take the stress out of your party ... keep your guests happy at every stage of the game. , “The key to ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... , Feb. 4, 2016  SciClone Pharmaceuticals, Inc. ... it has entered into a settlement agreement with ... fully resolving the SEC,s investigation into possible violations ... the terms of the settlement agreement, SciClone has ... including disgorgement, pre-judgment interest and a penalty.  This ...
(Date:2/4/2016)... Feb. 4, 2016 Global Immunology Market ... to drive long-term market growth Summary ... of chronic disorders that affect 5–7% of western ... of their symptoms and key patient demographics, they ... immune pathways and an inappropriate immune response. Generally, ...
(Date:2/4/2016)... DIEGO, Feb. 4, 2016  Aethlon Medical, Inc. ... affinity biofiltration devices to treat life-threatening diseases, today ... 2016 ended December 31, 2015. ... objectives set forth in our last quarterly call, ... reinforce our long-term objective to establish the Aethlon ...
Breaking Medicine Technology: