Navigation Links
Details of gene pathways suggest fine-tuning drugs for child brain tumors
Date:3/26/2013

Pediatric researchers, investigating the biology of brain tumors in children, are finding that crucial differences in how the same gene is mutated may call for different treatments. A new study offers glimpses into how scientists will be using the ongoing flood of gene-sequencing data to customize treatments based on very specific mutations in a child's tumor.

"By better understanding the basic biology of these tumors, such as how particular mutations in the same gene may respond differently to targeted drugs, we are moving closer to personalized medicine for children with cancer," said the study's first author, Angela J. Sievert, M.D., M.P.H., an oncologist in the Cancer Center at The Children's Hospital of Philadelphia.

Sievert, working with co-first author Shih-Shan Lang, M.D., in the translational laboratory of neurosurgeon Phillip Storm, M.D., and Adam Resnick, Ph.D., published a study ahead of print today in the Proceedings of the National Academy of Sciences.

The study, performed in cell cultures and animals, focused on a type of astrocytoma, the most common type of brain tumor in children. When surgeons can fully remove an astrocytoma (also called a low-grade glioma), a child can be cured. However, many astrocytomas are too widespread or in too delicate a site to be safely removed. Others may recur. So pediatric oncologists have been seeking better options---ideally, a drug that can selectively and definitively kill the tumor with low toxicity to healthy tissue.

The current study focuses on mutations in the BRAF gene, one of the most commonly mutated genes in human cancers. Because the same gene is also mutated in certain adult cancers, such as melanoma, the pediatric researchers were able to make use of recently developed drugs, BRAF inhibitors, which were already being tested with some success against melanoma in adults.

The current study provides another example of the complexity of cancer: in the
'/>"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Report Details Steps to Boost Patient Safety
2. ANY LAB TEST NOW®’s Terri McCulloch Details the Misconceptions about Drug and DNA Testing to Legal Investigators
3. New details on the molecular machinery of cancer
4. Scans Show Details of Damage to Soldiers With Head Injuries
5. Institute of Medicine report details for monitoring safety of childhood immunization schedule
6. IOM report details strategy for monitoring safety of childhood immunization schedule
7. MyPuress Releases Details About Groundbreaking New Product
8. Report Details Start of Steroid Meningitis Outbreak
9. Study details bullying involvement for adolescents with autism spectrum disorder
10. Stanford/Intel study details power of new chip to diagnose disease, analyze protein interactions
11. Researchers unveil molecular details of how bacteria propagate antibiotic resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... the Perelman School of Medicine at the University of ... have received an $8 million grant from the National ... light therapy (PDT) in patients with malignant pleural mesothelioma, ... manifests itself in the lining of the lungs and ... grant will fund a clinical trial and additional studies ...
(Date:7/9/2014)... metabolism of stromal support cells and immune cells ... types in the development of diseases could open ... That was the conclusion of a review article by ... journal Nature . , Prof. Peter Carmeliet: "Consider ... metabolism of cancer cells has been examined in minute ...
(Date:7/9/2014)... personal and subjective, the human brain turns them ... across different senses, situations and even people, reports ... Anderson. , "We discovered that fine-grained patterns of ... of the brain associated with emotional processing, act ... subjective feeling," says Anderson, associate professor of human ...
(Date:7/9/2014)... for more than watching World Cup highlights, Brian Williams ... landing in unfortunate positions on railings. A University of ... Online Journal shows that YouTube also allows researchers, ... public on topics of skin cancer and prevention. , ... the future of how we communicate around the world," ...
(Date:7/9/2014)... labels handed out by pharmacists may be misread ... according to new research by the University of ... Blind)., The study, published recently in the ... prescription medications dispensed by pharmacies do not consistently ... simply following recommended guidelines for font size, use ...
Breaking Medicine News(10 mins):Health News:Penn mesothelioma program receives $8 million NCI grant 2Health News:Wake-up call for more research into cell metabolism 2Health News:Study cracks how the brain processes emotions 2Health News:Study of dermatology on YouTube shows new ways science reaches public 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2
... conference organized in London by the Breast Cancer Campaign charity ... killer disease. //Instead it may become a long-term manageable disorder ... breast cancer patients has increased due to the significant developments ... revealed at the conference that the recurrence of the cancer ...
... with medical consultations and patients are seen tapping the ... medial ailments, especially ones they would like to hide ... infections scored very high on the search list and ... share of attention.NHS direct, the helpline is known to ...
... treatment was potentially beneficial in slowing and preventing ... (AMD). A recent study, the Complications of Age-Related ... from the National Eye Institute (NEI) of the ... laser treatment is ineffective in preventing complications of ...
... A recent research has found that more stress can lead ... restrain the cancer. //, ,A remarkable finding suggests that ... growth of cancer. Norepinephrine, a hormone released during stress stimulates ... tissue around tumor cells. This enables the cells to move ...
... a drug commonly prescribed to treat seizures and migraine ... stones//, researchers at UT Southwestern Medical Center have found. ... how the long-term use of topiramate affects kidney-stone formation ... Journal of Kidney Diseases. ,Several case reports ...
... major depression can become symptom-free if they are willing ... to determine which work best for them, which may ... the mix. ,The largest study on treatments for ... 67 percent of patients achieved a full remission of ...
Cached Medicine News:Health News:Breast Cancer may no longer be a killer disease 2Health News:People with early AMD not benefited by Laser Treatment 2Health News:More Stress, More Cancer 2Health News:More Stress, More Cancer 3Health News:Drug Prescribed for Migraines and Seizures Increases Risk of Kidney Stones 2Health News:Drug Prescribed for Migraines and Seizures Increases Risk of Kidney Stones 3Health News:Carefully Monitored Treatment Can Help Those Who Suffer from Depression 2Health News:Carefully Monitored Treatment Can Help Those Who Suffer from Depression 3
(Date:1/15/2014)...  In an unprecedented effort to curb the spread of "superbugs" such ... vehicles, an advanced and portable UV germicidal lamp manufactured by MRSA-UV ... In order to prevent EMS paramedics and transport ... West Palm Beach Fire Rescue is the first in ...
(Date:1/15/2014)... 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ECTE ... CGM System as a non-invasive, wireless continuous glucose monitoring ... Executive Chairman and Interim CEO of Echo Therapeutics, will ... Equity Conference. Mr. Doman will make ...
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces that ... in its catalogue: ... Analysis http://www.reportlinker.com/p01957812/Insulin-Pump-Market--Forecast-–-Worldwide-Analysis.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Equipment_and_Supply ... Insulin Pumps are gaining ...
Breaking Medicine Technology:Superbugs No Longer Ride In Rescue Vehicles 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
... , NEW YORK, Nov. 17 ... research report is available in its catalogue. ... Biomaterials 2009 (15 Countries) , ... 2008, the combined European biomaterial market was ...
... , BEIJING, ... developer and provider of vaccines in China, announced today that ... Administration,for Panflu.1, the Company,s H1N1 vaccine. The population has been ... for PANFLU.1 was extended to,one year from six months. , ...
Cached Medicine Technology:Reportlinker Adds European Markets for Orthopedic Biomaterials 2009 (15 Countries) 2Sinovac's PANFLU.1 (H1N1) Regulatory Approval Expanded to Include Geriatric Population 2
Sabre 180, 230V, 50Hz is a powerful niche generator....
High performance capabilities in a multipurpose generator, blended cut modes, simultaneous independent coagulation, low voltage coagulation, valleylab REM safety substantially reduces the risk of pat...
Lorgnette pinhole occluder...
Black multi-pinhole occluder...
Medicine Products: