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Detailed Results from RV 144 HIV Vaccine Trial Published Today in The New England Journal of Medicine and Presented at the AIDS Vaccine 2009 Conference Provide Insight for Future Research
Date:10/20/2009

ol University, the Armed Forces Research Institute of Medical Sciences - U.S. and Thai components, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, sanofi pasteur, Global Solutions for Infectious Diseases and the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

RV144 Trial Background

RV144 tested a prime-boost vaccine strategy that combined two vaccines based on strains (subtypes) of HIV that circulate in Thailand. The first, or "prime" vaccine, known as ALVAC HIV, was developed by sanofi pasteur and the booster vaccine, AIDSVAX B/E, was originally developed by VaxGen and is now licensed to Global Solutions for Infectious Diseases.

The proof-of-concept study, which began in 2003, was designed to evaluate the vaccine strategy's ability to prevent HIV infection, as well as its ability to reduce the amount of HIV in the blood of those who became infected after they enrolled in the study.

More than 16,000 HIV-negative men and women between the ages of 18 to 30 years participated in the study; half of these participants received the prime-boost vaccine regimen and half received placebo. Volunteers received vaccinations over the course of six-months and were followed for an additional three-year period. Before agreeing to participate, all volunteers were informed of the potential risks associated with receiving the experimental vaccine regimen used and consented to participate in the study. Volunteers continued to receive an HIV test every six-months for three-years following vaccination, in addition to counseling on how to prevent becoming infected with HIV.

SOURCE U.S. Military HIV Research Program


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SOURCE U.S. Military HIV Research Program
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