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Detailed Results from RV 144 HIV Vaccine Trial Published Today in The New England Journal of Medicine and Presented at the AIDS Vaccine 2009 Conference Provide Insight for Future Research
Date:10/20/2009

PARIS, Oct. 20 /PRNewswire-USNewswire/ -- Detailed results from the Prime-Boost HIV Vaccine Clinical Trial involving more than 16,000 adult volunteers in Thailand show that an investigational HIV vaccine regimen was safe and modestly effective at reducing the rate of HIV infection compared to placebo. These results were presented today by the trial collaborators to researchers gathered at the AIDS Vaccine 2009 Conference in Paris, France and published online by The New England Journal of Medicine.

"This is the first evidence that a prime-boost HIV vaccine regimen may prevent infection and represents a significant step forward for vaccine research," said Colonel Nelson Michael, Director, Division of Retrovirology, Walter Reed Army Institute of Research and Director, U.S. Military HIV Research Program (MHRP). "While it will not likely have any immediate public health benefit, we are hopeful that the findings will guide additional studies and accelerate research efforts toward a more effective vaccine."

According to the collaborating partners, the prime-boost combination of ALVAC HIV and AIDSVAX B/E appeared to lower the rate of HIV infection by 31.2 percent compared to placebo based on the modified intent-to-treat (mITT) population (n=51 vs. n=74, respectively; p=0.04). There was no effect on the amount of virus in the blood of the study volunteers who received either vaccine or placebo and subsequently became infected with HIV.

"Experts are interpreting the results and planning additional studies to maximize the knowledge gained from this study. Our first step is to see if we are able to determine correlates of protection," said Colonel Jerome Kim, Deputy Director (Science), MHRP and the HIV vaccines product manager for the U.S. Army. "Observations will inform future basic research, non-human primate and clinical studies to build on the RV144 result."

"All of this together emphasizes the opportunities
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SOURCE U.S. Military HIV Research Program
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