Navigation Links
'Destruct' triggers may be jammed in tumor cells, UF geneticists say
Date:4/30/2008

resistant transformation takes place in people during the development of brain cells, which are extremely sensitive to radiation in their formative stages but more durable once they grow into adult neurons.

However, the underlying cellular and molecular causes of the transformations were undetected. The latest findings suggest that like the fruit fly cells, tumor cells may have a degree of epigenetic protection from radiotherapy or chemotherapy.

We are talking about a piece of DNA that is very sensitive when open, but modification of its supporting structure has caused it to condense, said Zhou, who is affiliated with the UF Shands Cancer Center and the UF Genetics Institute. If we reverse this and open the DNA supporting structure, we can conceivably make the cells sensitive to radiation once more. Controlling the blocking-unblocking mechanism to make the cells sensitive could potentially lead to better cancer therapy.

Conceivably, certain drugs that open enhancer regions of cell-death genes in tumor cells could improve the effectiveness of cancer treatments.

The scientists took a different approach to look at the regions of the genome important for DNA-damage induced cell death, said Kristin White, Ph.D., an associate professor of dermatology at Harvard Medical School and Massachusetts General Hospital, who did not participate in the research. One of the most interesting aspects of this work is the finding that changes in chromatin structure regulate the expression of genes that are important in this death, and that this regulation can extend over long distances in the genome.

The research shows there is still a lot to learn about DNA damage-induced cell death, she said. We need to understand all aspects of this if we want to improve cancer therapy. This work suggests that we need to look harder at chromatin-modifying enzymes as new targets to alter the response of cancer cells to radiation.


'/>"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Familial MS May Be More Destructive
2. Researchers seek to make cavity-causing bacteria self-destruct
3. Researchers find new way to block destructive rush of immune cells
4. How do infections and toxins launch a cells self-destruct and alarm system?
5. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
6. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
7. Kaiser Permanente study: Alcohol amount, not type -- wine, beer, liquor -- triggers breast cancer
8. Scripps research scientists discover chemical triggers for aggression in mice
9. A protein that triggers aggressive breast cancer
10. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
11. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... 20, 2014 Atore, Inc, (San Francisco, ... launched first birthday focused portal on December 17th, 2014. ... launched in both US and Japan. , MERRY BIRTHDAY ... http://merrybirthday.net/message/ , MERRY BIRTHDAY MESSAGE is part ... the world. , Features, Choose from thousands of stock ...
(Date:12/20/2014)... December 20, 2014 Developers of ... of a new plugin for Final Cut Pro X ... “TranSlice Volume 5 allows users to create hand drawn ... Said Christina Austin, CEO of Pixel Film Studios. “TranSlice ... professionalism while maintaining an easy to use interface.” , ...
(Date:12/20/2014)... Parker & Sons, Inc. a focused and dedicated ... contractor services announces reaching a milestone by providing 40 ... Arizona. Parker and Sons is comprised of a reliable ... customer service the number one priority. The company was ... one service vehicle and has since grown to become ...
(Date:12/19/2014)... Colorado (PRWEB) December 20, 2014 It’s very ... travel is something that is put to the wayside until ... who still have that travel “itch” and that burning desire ... Montrose accommodates families on their journey to Telluride with a ... get visitors to and from the resort, and ensure that ...
(Date:12/19/2014)... Energy Textiles is excited to ... Celliant, the world’s leading responsive textile, can now ... There are a number of benefits to wearing ... and balanced body temperature; which can lead to ... enhanced athletic performance; and overall wellness. In addition, ...
Breaking Medicine News(10 mins):Health News:Atore, Inc. Releasing the First Birthday Portal 2Health News:Pixel Film Studios released a new transition entitled TranSlice Volume 5 exclusively for Final Cut Pro X 2Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 2Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 3Health News:Days Inn Montrose Colorado Delivers Last Minute Holiday Season Ski Getaway Accommodations 2Health News:Energy Textiles Launches Celliant Revitalizing Bedsheets 2
... available in French . , ,Hamilton, ... today announced a new study that will increase the ... Member of Parliament for Ancaster-Dundas-Flamborough-Westdale, made the announcement on ... , "This long-term study of 50,000 Canadians will look ...
... Clinic study, a history of child abuse significantly impacts ... are an increase in suicide attempts, prevalence of substance ... disorder. Additionally, these victims also had an earlier onset ... for psychiatric issues. The study was presented at the ...
... Elimination of funding for the Governor,s ... Senate Republican budget plan would end a wide range ... health care cost increases, improving quality of care and ... past two years the small "think tank" office has ...
... part of its ongoing initiative to promote early ... Alzheimer,s Foundation of America (AFA) recently introduced a ... country to offer free, confidential memory screenings and ... the way for local groups to host screenings ...
... The Commission for Case Manager Certification (CCMC) is ... Scholarship. August 1 is the deadline to apply for ... cover the cost of tuition, travel, and expenses at ... in October, during Case Manager Week. The case manager ...
... 21 Advana Science ( www.advanascience.com ) announced ... disease, has been named scientific advisor to the Company. ... 16, Issue 3), Dr. Smith was ranked third in the ... 2009. Dr. Smith brings over 20 years of research ...
Cached Medicine News:Health News:Government of Canada supports research to improve the health of future generations of Canadians 2Health News:Senate Republican Budget Would End Health Initiatives That Save Lives and Money 2Health News:Senate Republican Budget Would End Health Initiatives That Save Lives and Money 3Health News:Senate Republican Budget Would End Health Initiatives That Save Lives and Money 4Health News:Alzheimer's Foundation of America Promotes Free Memory Screenings Year-Round 2Health News:Alzheimer's Foundation of America Promotes Free Memory Screenings Year-Round 3Health News:CCMC Accepting Applications for Second Annual Patricia McCollom Scholarship Through Aug. 1 2Health News:Leading Alzheimer's Disease Researcher Mark A. Smith, PhD Named Scientific Advisor at Advana Science 2Health News:Leading Alzheimer's Disease Researcher Mark A. Smith, PhD Named Scientific Advisor at Advana Science 3
(Date:12/19/2014)... 18, 2014 Radiology information ... is used to store, manipulate, and distribute patient ... patient tracking and scheduling system, result reporting, and ... with HIS and other databases improves the hospital ... patient scheduling, patient list management, radiology department workflow ...
(Date:12/19/2014)... REDWOOD CITY, Calif., Dec. 18, 2014 ... on the development of medical diagnostics based on ... of gas flow, today announced financial results for ... 30, 2014. "Following the completion of ... well positioned to maximize the recently initiated CoSense® ...
(Date:12/19/2014)... and LYON, France , Dec. 19, ... LLY ) and Adocia (Euronext Paris: FR0011184241 – ADOC) ... an ultra-rapid insulin, known as BioChaperone Lispro, for treatment ... BioChaperone Lispro relies on Adocia,s proprietary BioChaperone® technology and ... and Adocia will develop BioChaperone Lispro with the goal ...
Breaking Medicine Technology:The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3Capnia Reports Third Quarter 2014 Financial Results 2Capnia Reports Third Quarter 2014 Financial Results 3Capnia Reports Third Quarter 2014 Financial Results 4Capnia Reports Third Quarter 2014 Financial Results 5Capnia Reports Third Quarter 2014 Financial Results 6Capnia Reports Third Quarter 2014 Financial Results 7Capnia Reports Third Quarter 2014 Financial Results 8Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3
... showed no consistent differences in bone mineral density ... Diskus 250/50 (fluticasone,propionate and salmeterol inhalation powder) and ... term use of Advair(R) in patients,with COPD, ... that data from a three-year study of patients ...
... BRANFORD, Conn., Oct. 29 CuraGen Corporation,(Nasdaq: ... announced today that Company executives will be holding ... on Monday, November 3, 2008,following the release of ... data from CuraGen,s Phase II clinical trial evaluating,CR011-vcMMAE ...
Cached Medicine Technology:Study Found That Long Term Use of Advair Diskus(R) 250/50 Did Not Adversely Affect Bone Loss in Patients with COPD 2Study Found That Long Term Use of Advair Diskus(R) 250/50 Did Not Adversely Affect Bone Loss in Patients with COPD 3CuraGen to Host Conference Call and Webcast to Discuss Third Quarter 2008 Financial Results and CR011-vcMMAE Phase II Trial Results on November 3, 2008 2
... with elastic fabric, these head cap systems ... to begin testing. Each Electro-Cap System features ... International 10-20 System. When you place your ... using with your head cap system and ...
... Made with elastic fabric, these head ... you need to begin testing. Each Electro-Cap ... to the International 10-20 System. When you ... you are using with your head cap ...
... When testing takes you into the OR, ... added protection of Cadwells new shielded electrodes. Keeping ... bar, and paired disc electrode has a special ... from the damaging effects of 60-cycle interference. That ...
... (HA) orbital implant was conceived by Arthur ... after a comprehensive review of the literature ... manuscripts dating back to 1885 (Mules 1885). ... with the performance of contemporary implants, allowed ...
Medicine Products: