Navigation Links
Destined for disease: Breast cancer mutation regulates cell fate
Date:2/3/2011

A new study sheds light on why individuals who inherit a particular family of mutations have a high risk of developing a very aggressive form of breast cancer. The research, published by Cell Press on February 4th in the journal Cell Stem Cell, shows that breast tissue cells from these individuals make abnormal cell-fate decisions even before cancer develops and provides exciting new insights into the mechanisms behind one of the most lethal types of breast cancer.

There are many forms of human breast cancer. Mutations in the BRCA1 tumor suppressor gene are associated with the development of the "basal-like" subtype of breast cancer which exhibits a very poor prognosis. "Recent evidence has indicated that BRCA1 might regulate breast cell differentiation," explains senior study author Dr. Charlotte Kuperwasser, Associate Professor in anatomy and cellular biology from Tufts University School of Medicine and member of the Sackler School of Graduate Biomedical Sciences at Tufts. "We wanted to examine whether BRCA1's role in differentiation was associated with the increased development of basal-like breast cancer."

Dr. Kuperwasser's group examined disease-free breast tissues from patients with normal or mutant BRCA1 genes. Using an ingenious strategy that allowed them to mimic the environment of intact human breast tissue, they transplanted the human cells into mice and looked at the types of tumors that formed after the cells were exposed to additional cancer-promoting signals. Although the cells with normal BRCA1 grew into different kinds of breast cancer, the cells from women with BRCA1 mutations mostly formed the aggressive basal-like tumors. Importantly, molecular analysis of disease-free breast cells with mutated BRCA1 revealed that even before tumors developed, the mutant cells were more likely to remain immature and contain elevated levels of a protein called Slug. The researchers showed that when Slug is present in the breast, cel
'/>"/>

Contact: Elisabeth Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Shorter Sleep in Men Ups Risk of Heart Disease: Study
2. Air Pollution Ups Risk of Chronic Lung Disease: Study
3. Parkinsons disease: Excess of special protein identified as key to symptoms and possible new target for treatment with widely used anti-cancer drug imatinib
4. Chronic Lyme disease: How often is it diagnosed and treated?
5. HIV/AIDS treatment curbs spread of disease: UBC-BC CfE study
6. Crohn's & Colitis Foundation National Event Helping Women Manage Inflammatory Bowel Disease: Two Women Physician Experts and Researchers in IBD on Interactive Webcast/Teleconference
7. Patients at high risk of recurrences of heart disease: Breakthrough in prevention
8. Understanding causes of cancer and chronic disease: The Canadian Partnership for Tomorrow Project
9. Thyroid Disease: The Hidden Epidemic
10. Princeton scientists discover mechanism involved in breast cancers spread to bone
11. Breast cancer cells outsmart the immune system and thrive
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... (PRWEB) September 21, 2014 Faculty and staff ... a coed preschool in Owings Mills, Md., kicked off the ... Garmin Vivofit bands. GFS is the first independent school to ... calories burned and even sleep patterns— as part of a ... area running and walking specialty chain. The Vivofit bands are ...
(Date:9/20/2014)... Recently, iFitDress.com, a well-known wedding dress manufacturer and ... dresses . In addition, the company has launched a special ... promotion is to benefit all of its big fans. Worldwide ... now. , Along with beautiful party dresses, the company ... recently released its new sexy short prom outfits and purple ...
(Date:9/20/2014)... Las Vegas, NV (PRWEB) September 21, 2014 ... and method created by fitness expert Craig Ballantyne that is ... boost their metabolism and blast away stubborn body fat using ... the attention of Shane Michaels, prompting an investigative review. ... equation isn’t always calories in vs. calories out for all ...
(Date:9/20/2014)... Increases in household, construction and commercial ... volumes. However, government regulations and higher landfill disposal ... to IBISWorld industry analyst Alen Allday, “over the ... reducing the volume of waste generated, and increasing ... a large proportion of waste generated by households ...
(Date:9/20/2014)... York, New York (PRWEB) September 20, 2014 ... filings continue to grow in federal court, Bernstein ... Food & Drug Administration (FDA) have voted overwhelmingly ... low testosterone in men be subjected to further ... According to a report published on September 18th ...
Breaking Medicine News(10 mins):Health News:Garrison Forest School Leader in Independent School Wellness Programs 2Health News:Beautiful Party Dresses For Autumn Unveiled By iFitDress.com 2Health News:6 Minutes to Skinny: Review Exposes Craig Ballantyne’s Method to Jump Starting the Metabolism and Blasting Away Body Fat in Just 6 Minutes Per Day 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 2Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 3
... doubled their odds of success , , FRIDAY, ... can improve the chances that blacks who have kidney ... found. , "Research overwhelmingly indicates that African-Americans are less ... differences in socioeconomic and insurance status and patient preference," ...
... in New Financing- DailyMed(TM) Sales Expected to Increase More ... Resources, Inc. (NYSE Amex: KAD ), a ... the Arcadia HealthCare(SM) brand, today announced that it has ... outstanding debt, extending the maturity to April 2012, and ...
... March 27 Emageon Inc. (Nasdaq: EMAG ), ... networks, today announced that it and the other named defendants ... March 13, 2009 in connection with the proposed acquisition of ... entered into a memorandum of understanding with counsel for the ...
... of a single-engine turboprop plane in Montana killed 14 people ... crashes in recent months, including the February 12th crash of ... "Miracle on the Hudson" in which all 155 people survived, ... The horror of such an event is unimaginable, but author ...
... an estimated 1.5 million people in 2007. By 2013, the ... as many as 4 million Americans and that the cost ... $400 billion, making it the nation,s fastest-growing developmental disability. In ... the DePaul University College of Law will explore ...
... Illinois Medical District Commission , ... Chicago, IL (PRWEB) ... (IMD), the nation,s largest urban healthcare, educational, research and technology district, ... its Commission. Harte comes to the IMD with a strong background ...
Cached Medicine News:Health News:Networking May Aid Blacks Who Need Kidney Transplant 2Health News:Arcadia Completes New Financing; Previews Fourth Quarter Results 2Health News:Arcadia Completes New Financing; Previews Fourth Quarter Results 3Health News:Arcadia Completes New Financing; Previews Fourth Quarter Results 4Health News:Arcadia Completes New Financing; Previews Fourth Quarter Results 5Health News:Arcadia Completes New Financing; Previews Fourth Quarter Results 6Health News:Arcadia Completes New Financing; Previews Fourth Quarter Results 7Health News:Emageon Settles Shareholder Class Action Lawsuit 2Health News:Emageon Settles Shareholder Class Action Lawsuit 3Health News:Emageon Settles Shareholder Class Action Lawsuit 4Health News:What Is It Like to Survive a Plane Crash? A Survivor of One of the Worst Small Plane Crashes Tells Her Story 2Health News:Health Law Institute at DePaul University College of Law to Host Autism Symposium on World Autism Day, April 2 2Health News:Meghan Harte Appointed to the Illinois Medical District Commission 2
(Date:9/19/2014)... WHITEHOUSE STATION, N.J. , Sept. 19, 2014 Merck ... the United States and Canada , ... on Desafiando La Diabetes: Logra Tus Metas , an educational ... of their blood sugar -- a key treatment goal to help ... the United States are at a higher risk for ...
(Date:9/19/2014)... Five MinuteClinic walk-in medical clinics are opening inside select CVS/pharmacy stores ... opened in Memphis and Cordova ... in Springfield on September 24 and a ... open October 22.  MinuteClinic is the largest and fastest growing provider ... . The Memphis -area clinics join ...
(Date:9/19/2014)... Mass. , Sept. 19, 2014  Pressure ... today announced it has received and approved all ... HT48 instruments and has begun to manufacture the ... first instrument will be ready for shipment by ... built and released at a rate of about ...
Breaking Medicine Technology:Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3
... June 27 /CNW/ -,Aspreva Pharmaceuticals Corporation (NASDAQ: ASPV; ... a clinical trial,comparing CellCept (oral mycophenolate mofetil, MMF) ... of care, for,inducing treatment response in the induction ... rates were similar in both arms, the trial ...
... WIRE)--Jun 27, 2007 - PrimeCell(TM),Therapeutics LLC (http://www.primecelltherapeutics.com) ... pre-clinical,studies for a clinical trial to assess ... bone marrow stem cells into,spinal cord injury ... preliminary report at the 13th,Annual Meeting of ...
Cached Medicine Technology:Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 2Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 3Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 4Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 5Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 6Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 7Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 8Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for,Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical,Study 2
... Heavy Duty is a pressure relief mattress overlay ... specifically to the BariKare® Bed., ,INDICATIONS , ... lbs., Large patients at risk or suffering from ... mattress that would benefit from a pressure relief ...
... bariatric bed system which helps provide comfort ... care setting, ,INDICATIONS: ,Patients weighing up ... 2) ,Healthcare frame accommodating one or two ... ,CONTRAINDICATION: ,Total weight in excess of ...
... The BariMaxx™ is a full-featured healthcare ... environment for the care and management of ... up to 1000 lbs. ,Large patients at ... weight in excess of 1000 lbs. (including ...
EC+ Extra Care Bariatric Bed...
Medicine Products: