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Despite Availability of Generic Equivalents, Two-Thirds of Neurologists Will Continue to Prescribe Branded Anti-Epileptic Drugs to Epilepsy Patients
Date:1/5/2009

generic version of Depakote ER. Physicians' concerns are a result of this agent's narrower therapeutic index and its narrower margin for error in generic equivalence."

The report also finds that brands facing generic competition will be dropped or pushed to tier three of many managed care organizations' (MCO) formularies. After March 2009, when generic versions of UCB's Keppra, Ortho-McNeil's Topamax and Depakote ER have become available, more than half of 20 surveyed private plans will remove Keppra and Topamax from their formularies and another five plans will shift these brands to tier three. By contrast, Depakote ER will retain favorable placement in 50 percent of surveyed plans.

Will Prescribers and Payers Allow Branded AEDs to Stem the Tide of Generics in Epilepsy, Migraine, Neuropathic Pain or Bipolar Disorder? is based on a U.S. survey of 70 psychiatrists and 70 neurologists and 20 MCO pharmacy directors. Their responses were compared to assess similarities and differences of opinion regarding clinical, economic and scientific factors.

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