Navigation Links
'Designer' sedative may provide new alternative for colonoscopy
Date:10/28/2013

San Francisco, CA. (October 28, 2013) Developed using molecular-level techniques, the "designer" sedative drug remimazolam provides a promising new alternative for sedation in patients undergoing colonoscopy, reports a study in the November issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

"Remimazolam has the attributes of a sedative drug, with success rates comparable with recent studies of other drugs," according to the new research, led by Dr Mark T. Worthington of Johns Hopkins Hospital, Baltimore.

Remimazolam Shows Fast Onset of Sedation and Quick Recovery

The researchers evaluated the use of remimazolam, a new benzodiazepine-type sedative drug, for sedation in patients undergoing colonoscopy. As described in a recent article in Anesthesia & Analgesia, remimazolam is an example of new anesthetic and sedative drugs being developed with the use of molecular-level techniques. Remimazolam was specifically designed to have a faster onset, more predictable effects, and shorter recovery time compared to currently available sedatives.

In the "dose-finding" study, 44 volunteers received one of three different doses of remimazolam. Across dose groups, remimazolam successfully provided an adequate level of sedation for colonoscopy in three-fourths of patients.

Remimazolam achieved adequate sedation less than one minute after drug administration. Afterwards, all subjects "rapidly recovered to fully alert"the median recovery time was less than 10 minutes.

A few subjects did not achieve adequate sedation or had minor adverse events, such as a drop in blood pressure. There were no serious or unexpected adverse events, however.

Further experiments showed that the sedative effect of remimazolam could be rapidly reversed using flumazenilan approved medication that blocks the benzodiazepine receptor. Patients regained full alertness within one minute after flumazenil injection.

Colonoscopy is commonly performed as a screening test for colorectal cancer. For this and other brief medical procedures, some form of sedative is needed to minimize patient discomfort and optimize performance of the procedure. The ideal sedative would have a fast onset and good quality of sedation, along with rapid recovery time.

Conventional benzodiazepines provide effective sedation but relatively long recovery timespatients may not return to their normal level of alertness and functioning for several hours after the procedure. The new study is the first to compare the effects of various doses of remimazolam as sedative for colonoscopy.

The new results show "very encouraging" success rates with remimazolam, Dr Worthington and coauthors write. With its fast onset and quick recovery timeincluding the ability to reverse sedation almost immediately, if neededremimazolam could be a valuable new sedative option for use in colonoscopy and other brief medical procedures. However, the researchers note that further studies will be needed to "refine the optimal dosing regimen" before remimazolam goes into widespread clinical use.

Read the article in Anesthesia & Analgesia


'/>"/>

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Related medicine news :

1. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
2. NJIT designer creates an ergonomic chair for musicians
3. Circadian clock research may enable designer plants, and cancer and diabetes treatments
4. Websites Touting Designer Vagina Surgeries Often Inaccurate, Study Finds
5. Chicago Hat Designer Tonya Gross Selected by Online Retailer Zappos.com for 2013 Emerging Designer Program
6. Author/Designer Perla Lichi Links Her Coffee Table Book "Palaces" With Upcoming On-Line Training Course
7. Contemporary Heaven Launches High-End Traditional and Modern Designer Pendant Lights
8. Dr. Daniel Strader of Dallas Designer Smiles Receives Top Reviews as Local Dallas, TX Dentist for Biological Dentistry
9. Fashion Designer Jenny Rose Creates Arabic Swimwear
10. Renowned Jewelry Designer Kendra Scott Hosted a Successful ‘Kendra Gives Back’ Party Benefitting Colleen’s Dream Foundation in Scottsdale, AZ
11. Dolabany Eyewear Adds Feminine Flare to Women's Designer Eyewear with 2013 New Release of Adelina by Best Image Optical, Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... , ... Apple Rehab Shelton Lakes , which specializes in the delivery ... as part of a disaster drill on October 3rd. , Apple Rehab participated with ... Manager, as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of ... Philippines. “The Journey: From the Mountains to the Mission Field” is the creation of ... taught all ages and currently teaches a class of ladies at her church, which ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... , Sept. 28, 2017 Hill-Rom Holdings, Inc. ... earnings conference call and webcast on Friday, November 3, ... (EDT) and ending at approximately 8:30 a.m. (CDT) / ... the company,s 2017 financial performance and guidance for 2018, ... initiatives to enhance operational performance, and long-range financial outlook ...
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
Breaking Medicine Technology: