The results of the study suggested that relatively low amounts of cruciferous vegetables in the diet a few portions per week can have large effects on gene expression by changing cell signalling pathways. These signalling pathways are the routes by which information is transmitted through a molecular cascade which amplifies the signal to the nucleus of the cell where gene expression occurs.
The Norwich-based team are currently planning a larger study with men with localised prostate cancer, and will compare the activity of standard broccoli with the special variety of high glucosinolate broccoli used in the current study.
Designer studies for health promotion
"Other fruits and vegetables have been shown to also reduce the risk of prostate cancer and are likely to act through other mechanisms," says Professor Mithen.
"Once we understand these, we can provide much better dietary advice in which specific combinations of fruit and vegetable are likely to be particularly beneficial. Until then, eating two or three portions of cruciferous vegetable per week, and maybe a few more if you lack the GSTM1 gene, should be encouraged."
|Contact: Zoe Dunford|
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