Navigation Links
Described novel regulator of a protein inactive in over 50 percent of human tumors
Date:7/21/2014

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors. The study results were published in the Journal of Biological Chemistry.

Regulation of the activity of p53 by HERC2

The team of Jos Luis Rosa, at the growth factors and cell differentiation research group at IDIBELL studies the molecular mechanisms of HERC family proteins. These proteins are ubiquitin ligases that regulate the function of other proteins. "In recent years," explained Rosa "it has been shown that alterations in HERC family proteins are associated with various pathologies including ataxia, mental retardation and cancer."

"Under physiological conditions, the role of the p53 protein is to protect from uncontrolled cell growth. Thus, mutations or other mechanisms to inhibit the function of p53, are associated with increased cell proliferation" as the researcher says "as a tumor is formed by uncontrolled cell growth, it is not surprising that an important step in tumor progression would be the inactivation of p53."

P53 protein regulates the expression of genes involved in important cellular processes such as cell proliferation. Its activity is dependent on acquiring a structure of four associated molecules called tetramer. Researchers have found that HERC2 is necessary for the formation of the tetramer of p53 (termed oligomerization process) and thus HERC2 regulates p53 activity under physiological conditions.

HERC2 and cancer

The study suggests that mutations in HERC2 also may be associated with cancer in humans. "In the laboratory we have observed that without HERC2 cells increases proliferation. It's the same effect as if they inactivated p53" says Rosa.


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert  

Page: 1

Related medicine news :

1. International committee re-defines how multiple sclerosis is described and understood
2. Impact of battlefield-related genitourinary injuries described in Journal of Mens Health
3. Obesity treatment breakthrough described in EurekAlert!s No. 1 most-visited news release in 2012
4. Is housework a health hazard? Sheet-Fitting palsy described by wake forest baptist physicians
5. New coral reef crustacean described and named after late reggae performer Bob Marley
6. Anti-cocaine vaccine described in Human Gene Therapy Journal
7. Novel mechanism for invasion of EV71 virus demonstrated
8. Kyowa Hakko’s Citicoline Obtains Novel Food Registration status in Europe
9. NIH launches Phase I clinical trial of novel drug to treat Clostridium difficile infection
10. NUS researchers discover novel protein complex with potential to combat gastric cancer
11. New possibilities for leukemia therapy with a novel mode of leukemia cell recognition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Described novel regulator of a protein inactive in over 50 percent of human tumors
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
(Date:6/24/2016)... Mass. and SAN CLEMENTE, Calif. , ... California -based mobile pulmonary function testing company, is now able ... PFT devices developed by ndd Medical Technologies , Inc. ... testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® ... , can get any needed testing done in the comfort ...
(Date:6/24/2016)... -- According to a new market research ... Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, 8mm, ... Purchase (Retail, Non-Retail) - Trends & Global Forecasts to ... for the forecast period of 2016 to 2021. This ... 2021 from USD 1.65 Billion in 2016, growing at ...
Breaking Medicine Technology: