Derma Sciences Enrolls First Patient in DSC127 Phas...(matology Plasticand Reconstructive Surge...),Health

Derma Sciences Chief Scientific Advisor, Laura Bolton, Ph.D, whose involvement in wound care began in 1974 as a Johnson & Johnson Scientist and continued in Wound Care R&D before retiring in 2006 as Global Director of Scientific Affairs at ConvaTec, a Bristol-Myers Squibb company, said, "This is the most rigorously researched, most promising active wound healing agent I have seen. The clinical studies are well-designed to test the promise of this unusually versatile and effective molecule in diabetic foot ulcers. If results match the pre-clinical findings, surpassing moisture-retentive dressing and growth factor effects, diabetic patients will have a sterling option they can count on to help them heal their foot ulcers..."

About DSC127

The skin represents one of the few human tissues with a high turnover rate. Upon injury, the expression of receptors in injuried skin is upregulated and down regulates as the skin heals. In human skin, angiotensin II type 1 (AT1) and angiotensin II type 2 (AT2) receptors are found in the epidermis and in dermal vessel walls. DSC127, a novel angiotensin analog, has been shown to accelerate skin healing in a variety of animal models including wound repair after full-thickness excision in normal rats, in adriamycin or steroid-treated rats, in diabetic mice, after partial thickness thermal injuries in guinea pigs, and after random flap injuries in rats.

DSC127 upregulates a cassette of genes at the site of skin healing. These genes are involved in energy metabolism (glycolysis and electron transport), oxidative stress, and production of cytoskeletal proteins, all of which could be involved in the growth of new skin during wound healing. This finding suggests that DSC127 produces different actions at the wound site during various stages of healing. DSC127 appears to stimulate production
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