Navigation Links
Depression predicts increases in inflammatory protein linked to heart disease
Date:10/5/2009

INDIANAPOLIS Which comes first, depression or inflammation?

To help solve this long standing chicken and egg conundrum, researchers led by Jesse Stewart, Ph.D., assistant professor of psychology at Indiana University-Purdue University Indianapolis asked two critical questions. Does depression lead to elevated inflammatory proteins in the human body? Or does an increase in these proteins lead to depression? They found that the answer to the first question appears to be "yes," and the answer to the second question may be "no" among healthy adults.

The researchers report that depressive symptoms are associated with increases over time in interleukin-6, an inflammatory protein that predicts cardiovascular events. In contrast, levels of interleukin-6 were not related to later increases in depressive symptoms.

The new study, published in the October 2009 issue of the journal Brain, Behavior and Immunity, is the first to examine both directions of the depression-inflammation connection and to measure the physical symptoms of depression, such as fatigue and sleep disturbance, in addition to the cognitive-emotional symptoms, such as pessimism and sadness.

Several previous studies have linked depression to increased inflammatory protein levels measured at the same time. These studies, however, cannot speak to which is the cause and which is the effect. "There is two-way communication between the brain and the immune system, so we had to determine whether activation of the body's immune system sent a signal to the brain to affect mood and behavior or whether the depression activated the immune system," said Dr. Stewart, a clinical health psychologist in IUPUI's School of Science and an IU Center for Aging Research affiliated scientist.

Participants in the study were 263 healthy men and women aged 50-70 years at the start of the study. They were tested at baseline and again six years later to determine their levels of depressive symptoms and interleukin-6. Levels of C-reactive protein, another inflammatory protein, were also measured but were not related to depression.

The strength of the association of depression with future heart disease is similar to that of traditional risk factors like smoking, high blood pressure and elevated cholesterol, according to Dr. Stewart.

"Promotion of inflammation may be one pathway through which depression may 'get under the skin' to negatively influence cardiovascular health. The link to cardiovascular disease demonstrates that there may be physical as well as mental health reasons to treat depression," said Dr. Stewart.


'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

Related medicine news :

1. Physician-assisted suicide does not increase severity of depression, grief among family members
2. Less than 50 percent of men and women with depression see a doctor for treatment
3. U-M study: Life and death during the Great Depression
4. The Welcome Back Awards Seeks Nominations to Recognize Those Dedicated to the Depression Community
5. Predicting Postpartum Depression May Be Possible
6. New links among alcohol abuse, depression, obesity in young women found
7. Drinking, Weight, Depression Linked in Young Women: Study
8. Depression May Hasten Cancer Death
9. Depression increases cancer patients risk of dying
10. UCLA researchers develop biomarker for rapid relief of major depression
11. Prentice Womens Hospital Launches New Initiative to Better Identify and Address Postpartum Depression
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Depression predicts increases in inflammatory protein linked to heart disease
(Date:1/20/2017)... ... January 20, 2017 , ... Vitamin Well ... VW+ 002. The drinks have been produced in collaboration with Zlatan Ibrahimovic and ... your workout. , After a successful launch in Sweden last year, the next ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming and earnest tale ... each of his children. “The Angel” is the creation of published author, Marjorie Lund-Fontaine, ... City, and impassioned writer. , When asked of her new book, Marjorie says, “‘The ...
(Date:1/20/2017)... ... ... Forgive You”: a fine examination of how God handles sin, including how to let ... Stephen Miller, who, for over ten long years has been waiting to release this powerful ... Tobago, he has been serving the Lord for over twenty years, and he has been ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Christmas in Suffolk”: a story of ... Seymour, who lives in Lafayette, Indiana where she works in a daycare and looks ... writes. , Published by Christian Faith Publishing, Sara Seymour’s new book is an adventure ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: a moving ... is God’s Lighthouse” is the creation of published author, Gene Gaapf, a retired truck ... , “I have been writing since high school and have many different titles,” ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... January 19, 2017 The global  pacemaker market  is expected ... Grand View Research, Inc. The heightening prevalence of cardiac conditions coupled with the ... Pacemaker globally. In addition, technological enhancements in these devices are supporting the expansion ... ... Grand View Research Logo ...
(Date:1/19/2017)...   Synthetic Biologics, Inc. (NYSE MKT: ... to preserve the microbiome to protect and restore ... initiate a Phase 2b/3 adaptive pivotal trial for ... designed to reduce methane production by certain microorganisms ... treat the underlying cause of irritable bowel syndrome ...
(Date:1/18/2017)... DALLAS , Jan. 18, 2017  Aprima ... health records (EHR), practice management (PM) and revenue ... announced the acquisition of a former reseller Healthcare ... part of the agreement, Aprima will assume full ... providers in 125 medical practices across 15 states. ...
Breaking Medicine Technology: