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Depression and Alzheimer's Risk Linked
Date:4/7/2008

ygdala, thereby increasing the risk for Alzheimer's. However, Breteler's group didn't find any difference in the size of those areas of the brain in people with or without depression.

In addition, Breteler's team found that people who had symptoms of depression at the start of the study were no more likely to develop Alzheimer's than those who did not have the symptoms.

Even though the study found a connection between depression and Alzheimer's, experts continue to debate whether such a connection really exists.

"There are quite a few papers about the association between depression and Alzheimer's, with conflicting results," said Yaakov Stern, a professor of clinical neuropsychology at Columbia University in New York City. "No one really knows if there is a connection between depression and Alzheimer's."

Another expert questioned whether treating depression could prevent dementia.

"Depression may be a risk factor for developing dementia. I believe that's true," said Dr. Gary Kennedy, director of geriatric psychiatry at Montefiore Medical Center in New York City. "Depression is also one of the side effects of dementia.

"So there is an overlap relationship that makes it very difficult to look at the more interesting question of whether, if we treat depression could we prevent dementia," Kennedy said.

Kennedy noted that studies have shown that depression in older people appears to be an early sign of developing dementia. However, whether that's the beginning of dementia or an independent risk factor for dementia isn't known, he said.

Even though the clinical implications for the association between depression and dementia aren't clear, Kennedy believes that older people with depression should have their depression treated. "There's even more reason to make sure depression is aggressively treated," he said.

Adding to the debate about the relationship between Alzheimer's and depress
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Depression and Alzheimer's Risk Linked
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