Navigation Links
Depression With Psychotic-Like Symptoms Seems Tougher to Treat
Date:12/6/2010

MONDAY, Dec. 6 (HealthDay News) -- People with depression who also have psychotic-like symptoms, such as hearing voices or believing others are plotting against them, are less likely to respond to antidepressants, a new study finds.

It also found that bipolar disorder does not appear to be associated with treatment resistance in patients with depression, a finding that challenges the common theory that some cases of difficult-to-treat depression are actually unrecognized bipolar disorder, the researchers added.

They conducted the study to assess the link between bipolar disorder and treatment outcomes among 4,041 patients with depression. The patients first received the antidepressant citalopram (Celexa), followed by up to three next-step treatments, depending on their responses.

At the start of the study, 1,198 (30 percent) of the patients said they had experienced at least one psychotic symptom -- such as believing they had special powers or were being controlled or plotted against -- in the previous six months. These patients were significantly less likely to respond to treatment.

In addition, 1,524 patients (38.1 percent) said they had experienced at least one symptom of bipolar disorder in the previous six months. Of those symptoms, irritability was associated with poor treatment outcomes.

But several indicators commonly associated with bipolar disorder -- including history of manic symptoms and family history of the condition -- were not associated with patient responses to antidepressants, the researchers said.

The study was published online Dec. 6 in the Archives of General Psychiatry.

"Considered as a whole, our results cast doubt on the frequent assertion that unrecognized bipolar disorder is widespread in clinical practice and particularly in treatment-resistant major depressive disorder," the researchers, led by Dr. Roy H. Perlis, of Massachusetts General Hospital and Harvard Medical School, concluded in a news release from the journal.

"Screening for bipolar disorder among psychiatric patients remains important, as does considering individual risk factors such as family history or age at onset. Still, our findings indicate that, in most individuals presenting with a major depressive episode without a prior manic or hypomanic episode, unrecognized bipolarity does not appear to be a major determinant of treatment resistance," the researchers said.

More information

The U.S. National Institute of Mental Health has more about depression.

-- Robert Preidt

SOURCE: JAMA/Archives journals, news release, Dec. 6, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. Husbands hostile, anti-social behaviors increase wives symptoms of depression, researchers find
3. Acupuncture May Ease Depression During Pregnancy
4. Belief in a caring god improves response to medical treatment for depression
5. Stress hormone, depression trigger obesity in girls
6. Psychiatrys main method to prevent mistaken diagnoses of depression doesnt work: NYU study
7. Brain Balancing Gives Hope for Sufferers of Depression, Stress, and Insomnia at New Life Brain Center
8. Video games may help combat depression in older adults
9. Obesity and Depression: A Vicious Circle?
10. Major depression more than doubles risk of dementia among adults with diabetes
11. Study shows phyical therapy exercise program can reduce risk of postnatal depression in new mothers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... Payne, AL (PRWEB) , ... September 21, 2017 ... ... preparation provider with offices serving communities in northern Alabama and Georgia, is embarking ... breast cancer prevention by utilizing modern early detection methods. , US Breast ...
(Date:9/20/2017)... ... September 20, 2017 , ... FirstAlign ( http://www.firstalign.com ), ... latest Artificial Intelligence (AI) thinking, announced today the launch of its revamped web ... essential information that offers a more comprehensive understanding of the organization’s business and ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... a voice for people who have kidney disease. The theme “Describe a positive ... their stories. Entrants needed to meet only one qualification— to have been ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... much-anticipated fall event , Look Awesome This Autumn with CoolSculpting®. Scheduled for ... pricing and refreshments. , Mirror Mirror Beauty Boutique is Houston’s largest ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... innovation, the company recently unveiled a redesigned website. The new site – still ... of building owners, architects, contractors and other industry users that Garland serves. , ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017 Caris Life ... on fulfilling the promise of precision medicine, today ... the benefits of its molecular profiling approach in ... comprehensive genomic profiling plus (CGP+) with Caris Molecular ... tumor on a molecular level, leading to more ...
(Date:9/6/2017)... SAN ANTONIO , Sept. 6, 2017  Robert ... as a Pinnacle Professional Member in recognition of his ... Dr. Szewc serves as a Nephrologist at the practice ... services, emergency medicine, kidney care and hypertension solutions. He ... over 20 years of career experience, as well as ...
(Date:9/6/2017)... INDIANAPOLIS , Sept. 6, 2017 Eli ... today it will present new data for galcanezumab and ... Congress of the International Headache Society (IHC) taking place ... Lilly will highlight new, long-term data from ... two doses of galcanezumab (120 mg and 240 mg) ...
Breaking Medicine Technology: