Navigation Links
Depression With Psychotic-Like Symptoms Seems Tougher to Treat
Date:12/6/2010

MONDAY, Dec. 6 (HealthDay News) -- People with depression who also have psychotic-like symptoms, such as hearing voices or believing others are plotting against them, are less likely to respond to antidepressants, a new study finds.

It also found that bipolar disorder does not appear to be associated with treatment resistance in patients with depression, a finding that challenges the common theory that some cases of difficult-to-treat depression are actually unrecognized bipolar disorder, the researchers added.

They conducted the study to assess the link between bipolar disorder and treatment outcomes among 4,041 patients with depression. The patients first received the antidepressant citalopram (Celexa), followed by up to three next-step treatments, depending on their responses.

At the start of the study, 1,198 (30 percent) of the patients said they had experienced at least one psychotic symptom -- such as believing they had special powers or were being controlled or plotted against -- in the previous six months. These patients were significantly less likely to respond to treatment.

In addition, 1,524 patients (38.1 percent) said they had experienced at least one symptom of bipolar disorder in the previous six months. Of those symptoms, irritability was associated with poor treatment outcomes.

But several indicators commonly associated with bipolar disorder -- including history of manic symptoms and family history of the condition -- were not associated with patient responses to antidepressants, the researchers said.

The study was published online Dec. 6 in the Archives of General Psychiatry.

"Considered as a whole, our results cast doubt on the frequent assertion that unrecognized bipolar disorder is widespread in clinical practice and particularly in treatment-resistant major depressive disorder," the researchers, led by Dr. Roy H. Perlis, of Massachusetts General Hospital and Harvard Medical School, concluded in a news release from the journal.

"Screening for bipolar disorder among psychiatric patients remains important, as does considering individual risk factors such as family history or age at onset. Still, our findings indicate that, in most individuals presenting with a major depressive episode without a prior manic or hypomanic episode, unrecognized bipolarity does not appear to be a major determinant of treatment resistance," the researchers said.

More information

The U.S. National Institute of Mental Health has more about depression.

-- Robert Preidt

SOURCE: JAMA/Archives journals, news release, Dec. 6, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. Husbands hostile, anti-social behaviors increase wives symptoms of depression, researchers find
3. Acupuncture May Ease Depression During Pregnancy
4. Belief in a caring god improves response to medical treatment for depression
5. Stress hormone, depression trigger obesity in girls
6. Psychiatrys main method to prevent mistaken diagnoses of depression doesnt work: NYU study
7. Brain Balancing Gives Hope for Sufferers of Depression, Stress, and Insomnia at New Life Brain Center
8. Video games may help combat depression in older adults
9. Obesity and Depression: A Vicious Circle?
10. Major depression more than doubles risk of dementia among adults with diabetes
11. Study shows phyical therapy exercise program can reduce risk of postnatal depression in new mothers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Aliso Viejo, California (PRWEB) , ... June 26, 2016 , ... ... for Final Cut Pro X. , "Film editors can give their videos a whole ... artistically," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
Breaking Medicine Technology: